8,11-dihydro-10-methyl-8,11-diphenylpyrazolo<4',3':5,6>pyrano<3,2-e><1,2,4>triazolo<1,5-c>pyrimidine | 130593-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8,11-dihydro-10-methyl-8,11-diphenylpyrazolo<4',3':5,6>pyrano<3,2-e><1,2,4>triazolo<1,5-c>pyrimidine
• 英文别名: 8,11-dihydro-10-methyl-8,11-diphenylpyrazolo[4',3':5,6]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine；14-Methyl-12,16-diphenyl-10-oxa-3,5,6,8,12,13-hexazatetracyclo[7.7.0.02,6.011,15]hexadeca-1(9),2,4,7,11(15),13-hexaene
• CAS: 130593-33-8
• 化学式: C₂₂H₁₆N₆O
• 分子量: 380.409
• InChiKey: UOSALHJYOYOFRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  70.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-氨基-3-甲基-1,4-二苯基-1,4-二氢-吡喃o[2,3-c]吡唑-5-甲腈 在 乙酸酐 、 一水合肼 作用下， 以 乙醇 、 水 、 苯 为溶剂， 反应 8.75h， 生成 8,11-dihydro-10-methyl-8,11-diphenylpyrazolo<4',3':5,6>pyrano<3,2-e><1,2,4>triazolo<1,5-c>pyrimidine
  参考文献：
  名称：

  Synthesis of Various Pyrazolo[4′,3′ : 5,6]pyrano[3,2-e] [1,2,4]triazolo[1,5-c]pyrimidines and Pyrazolo[4″,3″ : 5′,6′]pyrano[2′,3′ : 4,5]pyrimido[1,6-b] [1,2,4]triazines

  摘要：

  通过 6-氨基-1,4,5,6-四氢-5-亚氨基-3-甲基-1,4-二苯基吡唑并[4′,3′：5,6]吡喃并[2,3-d]嘧啶 (3) 分别与 2-氰基-3-乙氧基-2-丙烯酸乙酯、乙氧基亚甲基丙二腈、氰乙酸乙酯、丙二腈、丙酮酸乙酯、草酰氯、氯甲酸乙酯和 3-甲基-4-亚硝基-1-苯基吡唑-5(4H)-酮反应。

  DOI：

  10.1055/s-1990-26989

文献信息

• [EN] [1,2,4]TRIAZOLO[1,5-A]PYRIDINE AND [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS [1,2,4]TRIAZOLO[1,5-A]PYRIDINE ET [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE ET LEUR UTILISATION
  申请人：CANCER REC TECH LTD

  公开号：WO2009047514A1

  公开（公告）日：2009-04-16

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

  本发明一般涉及治疗化合物领域，更具体地涉及某些三唑化合物（以下简称为TAZ化合物），特别是某些[1,2,4]三唑并[1,5-a]吡啶和[1,2,4]三唑并[1,5-c]嘧啶化合物，这些化合物等等，可以抑制AXL受体酪氨酸激酶功能。本发明还涉及包括这些化合物的药物组合物，以及使用这些化合物和组合物，无论是体外还是体内，来抑制AXL受体酪氨酸激酶功能，并用于治疗由AXL受体酪氨酸激酶介导的疾病和病况，通过抑制AXL受体酪氨酸激酶功能得到缓解的疾病和病况等，包括增生性疾病如癌症等。
• Synthesis of Various Pyrazolo[4′,3′ : 5,6]pyrano[3,2-<i>e</i>] [1,2,4]triazolo[1,5-<i>c</i>]pyrimidines and Pyrazolo[4″,3″ : 5′,6′]pyrano[2′,3′ : 4,5]pyrimido[1,6-<i>b</i>] [1,2,4]triazines
  作者：Mansour Ismail Younes、Saoud Abdel Monem Metwally、Aly Hussein Atta

  DOI：10.1055/s-1990-26989

  日期：——

  A number of heterocyclic compounds 5-13 were prepared by the reaction of 6-amino-1,4,5,6-tetrahydro-5-imino-3-methyl-1,4-diphenylpyrazolo [4′,3′:5,6]pyrano[2,3-d]pyrimidine (3) with ethyl 2-cyano-3-ethoxy-2-propenoate, ethoxymethylenemalononitrile, ethyl cyanoacetate, malononitrile, ethyl pyruvate, oxalyl chloride, ethyl chloroformate, and 3-methyl-4-nitroso-1-phenylpyrazol-5(4H)-one, respectively.

  通过 6-氨基-1,4,5,6-四氢-5-亚氨基-3-甲基-1,4-二苯基吡唑并[4′,3′：5,6]吡喃并[2,3-d]嘧啶 (3) 分别与 2-氰基-3-乙氧基-2-丙烯酸乙酯、乙氧基亚甲基丙二腈、氰乙酸乙酯、丙二腈、丙酮酸乙酯、草酰氯、氯甲酸乙酯和 3-甲基-4-亚硝基-1-苯基吡唑-5(4H)-酮反应。
• [1,2,4]Triazolo[1,5-a]Pyridine and [1,2,4]Triazolo[1,5-c]Pyrimidine Compounds and Their Use
  申请人：Cancer Research Technology Limited

  公开号：US20140155594A1

  公开（公告）日：2014-06-05

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

  本发明涉及治疗化合物领域，更具体地涉及某些三唑化合物（在此称为TAZ化合物），特别是某些[1,2,4]三唑并[1,5-a]吡啶和[1,2,4]三唑并[1,5-c]嘧啶化合物，其中包括抑制AXL受体酪氨酸激酶功能的化合物。本发明还涉及包括这些化合物的制药组合物，以及使用这些化合物和组合物在体内外抑制AXL受体酪氨酸激酶功能，并用于治疗由AXL受体酪氨酸激酶介导的疾病和病症，通过抑制AXL受体酪氨酸激酶功能得到缓解的疾病和病症，包括增生性疾病如癌症等。
• YOUNES, MANSOUR ISMAIL;MONEM, METWALLY SAOUD ABDEI;ATTA, ALY HUSSEIN, SYNTHESIS,(1990) N, C. 704-706
  作者：YOUNES, MANSOUR ISMAIL、MONEM, METWALLY SAOUD ABDEI、ATTA, ALY HUSSEIN

  DOI：——

  日期：——
• [1,2,4]TRIAZOLO[1,5-A]PYRIDINE AND [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE COMPOUNDS AND THEIR USE
  申请人：Cancer Research Technology Limited

  公开号：EP2217578B1

  公开（公告）日：2013-12-04