9-<1-(Benzotriazol-1-yl)-3-(morpholin-4-yl)propyl>carbazole | 146041-81-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-<1-(Benzotriazol-1-yl)-3-(morpholin-4-yl)propyl>carbazole
• 英文别名: 1-(benzotriazol-1-yl)-1-(carbazol-9-yl)-3-morpholinopropane；4-[3-(Benzotriazol-1-yl)-3-carbazol-9-ylpropyl]morpholine
• CAS: 146041-81-8
• 化学式: C₂₅H₂₅N₅O
• 分子量: 411.506
• InChiKey: QQQIMOQKIJMQQJ-UHFFFAOYSA-N

物化性质

• 沸点：
  598.2±50.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  48.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9-<1-(Benzotriazol-1-yl)-3-(morpholin-4-yl)propyl>carbazole 在 盐酸 、 正丁基锂 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.0h， 生成 4-Morpholin-4-yl-1-phenyl-butan-2-one
  参考文献：
  名称：

  3-(Dialkylamino)-1-(benzotriazol-1-yl)-1-(carbazol-9-yl)propanes: novel .beta.-aminoacyl anion equivalents

  摘要：

  DOI：

  10.1021/jo00059a066
• 作为产物：
  描述：

  N-乙烯基咔唑 、 (4-吗啉基甲基)苯并三唑 在 对甲苯磺酸 作用下， 反应 8.0h， 以43%的产率得到9-<1-(Benzotriazol-1-yl)-3-(morpholin-4-yl)propyl>carbazole
  参考文献：
  名称：

  3-(Dialkylamino)-1-(benzotriazol-1-yl)-1-(carbazol-9-yl)propanes: novel .beta.-aminoacyl anion equivalents

  摘要：

  DOI：

  10.1021/jo00059a066

文献信息

• Additions of 1-(aminomethyl)benzotriazoles to enamines, enamides, and vinyl ethers: novel routes to 1,3-diamines and tetrahydroquinolines
  作者：Alan R. Katritzky、Bogumila Rachwal、Stanislaw Rachwal

  DOI：10.1021/jo00056a006

  日期：1993.2

  New methods for the synthesis of 1,3-diamines and of 4-substituted tetrahydroquinolines are described in which the key step is the addition of the condensation products derived from amines, aldehydes, and benzotriazole to enamines, enamides, and vinyl ethers.
• Additions of 1-(.alpha.-Aminoalkyl)benzotriazoles to N-Vinylamines and N-Vinylamides. A Novel and Versatile Method for the Preparation of Unsymmetrically Substituted 1,3-Diamines
  作者：Alan R. Katritzky、Stanislaw Rachwal、Bogumila Rachwal

  DOI：10.1021/jo00097a023

  日期：1994.9

  Additions of N,N-dialkyl-1H-benzotriazole-1-methanamines 1 to 9-vinylcarbazole followed by reduction of the adducts with lithium aluminum hydride gave the corresponding 9-(3-(dialkylamino)propyl)carbazoles 8 in good yield. Treatment of the adducts with Grignard reagents gave products 9 with an alkyl or aryl group at the C-1 atom of the propylene linkage. Use of alpha-phenyl-N,N-dialkyl-1H-benzotriazole-1-methanamine (14) in the addition led to the C-3 phenyl substituted products 15-18. Similar additions to N-vinyl-N-methylacetamide or 1-vinyl-2-pyrrolidinone followed by reduction of the adducts gave unsymmetrically substituted 1,3-propanediamines. Triamine 36 was obtained by condensation of ethylamine with formaldehyde and benzotriazole, addition of the product to 1-vinylpyrrolidinone, and reduction of the adduct with lithium aluminum hydride. 1,3-Propanediamine used in this process gave hexahydropyrimidine 39 while 1,6-hexanediamine gave hexamine 42.
• Katritzky Alan R., Rachwal Stanislaw, Rachwal Bogumila, J. Org. Chem, 59 (1994) N 18, S 5206-5214
  作者：Katritzky Alan R., Rachwal Stanislaw, Rachwal Bogumila

  DOI：——

  日期：——
• 3-(Dialkylamino)-1-(benzotriazol-1-yl)-1-(carbazol-9-yl)propanes: novel .beta.-aminoacyl anion equivalents
  作者：Alan R. Katritzky、Zhijun Yang、Jamshed N. Lam

  DOI：10.1021/jo00059a066

  日期：1993.3