6-Hydroxy-2'-methoxyflavone | 61546-59-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6-Hydroxy-2'-methoxyflavone
• 英文别名: 6-hydroxy-2-(2-methoxyphenyl)-4H-chromen-4-one；6-hydroxy-2-(2-methoxy-phenyl)-chromen-4-one；6-Hydroxy-2-(2-methoxy-phenyl)-chromen-4-on；6-hydroxy-2-(2-methoxyphenyl)chromen-4-one
• CAS: 61546-59-6
• 化学式: C₁₆H₁₂O₄
• 分子量: 268.269
• InChiKey: OOGPSPVFDWHSGX-UHFFFAOYSA-N

物化性质

• 熔点：
  230-232 °C
• 沸点：
  489.3±45.0 °C(Predicted)
• 密度：
  1.329±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-Hydroxy-2'-methoxyflavone 在 三溴化硼 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 5.0h， 生成 5-(azetidin-1-ylmethyl)-6-hydroxy-2-(2-hydroxyphenyl)-4H-chromen-4-one
  参考文献：
  名称：

  Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads

  摘要：

  DOI：

  10.1016/j.bioorg.2021.105110
• 作为产物：
  描述：

  2'-hydroxy-5'-methoxymethoxyacetophenone 在 碘 、 potassium hydroxide 作用下， 以 乙醇 、 二甲基亚砜 为溶剂， 反应 0.33h， 生成 6-Hydroxy-2'-methoxyflavone
  参考文献：
  名称：

  Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists

  摘要：

  Farnesoid X receptor (FXR), a nuclear receptor mainly distributed in liver and intestine, has been regarded as a potential target for the treatment of various metabolic diseases, cancer and infectious diseases related to liver. Starting from two previously identified chalcone-based FXR antagonists, we tried to increase the activity through the design and synthesis of a library containing chalcones, flavones and chromenes, based on substitution manipulation and conformation (ring closure) restriction strategy. Many chalcones and four chromenes were identified as microM potent FXR antagonists, among which chromene 11c significantly decreased the plasma and hepatic triglyceride level in KKay mice. (C) 2017 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2017.02.037

文献信息

• Tire with rubber containing flavone
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP1391327A1

  公开（公告）日：2004-02-25

  The invention relates to a rubber composition and a pneumatic tire having a component comprising a rubber containing the reaction product of a flavone and a methylene donor.

  本发明涉及一种橡胶组合物和充气轮胎，其成分包括含有黄酮和亚甲基供体反应产物的橡胶。
• Rubber composition and tire with rubber containing flavone
  申请人：The Goodyear Tire & Rubber Company

  公开号：EP2730431A1

  公开（公告）日：2014-05-14

  A rubber composition comprising a diene based elastomer and an adhesion promoter derived from a flavone, a methylene donor and a methylene acceptor is disclosed. The rubber composition is essentially free of cobalt. Also, a pneumatic tire comprising such a rubber composition is disclosed.

  本发明公开了一种橡胶组合物，该组合物包含一种二烯基弹性体和一种由黄酮、亚甲基供体和亚甲基受体衍生的附着力促进剂。该橡胶组合物基本上不含钴。此外，还公开了一种包含这种橡胶组合物的充气轮胎。
• Methods For Treating Wounds
  申请人：Kimberly-Clark Worldwide, Inc.

  公开号：US20030125264A1

  公开（公告）日：2003-07-03

  Pharmaceutical compositions, and methods of using the same, are provided utilizing effective amounts of one or more flavones, flavonols, flavanones, isoflavanones and isoflavones to increase cell proliferation in various tissues and cell lines. As examples, the composition and methods of the present invention can be used to increase proliferation of fibroblast cells and, more particularly, in the treatment of wounds as well as strengthening of the skin.

  本发明提供了利用有效量的一种或多种黄酮、黄酮醇、黄烷酮、异黄烷酮和异黄酮来增加各种组织和细胞系的细胞增殖的药物组合物及其使用方法。举例来说，本发明的组合物和方法可用于增加成纤维细胞的增殖，特别是用于治疗伤口和强化皮肤。
• Methods of treating benzodiazepine site (BZD-S) associated syndromes using 2' hydroxyflavonoids
  申请人：Naturon Limited

  公开号：US20040034092A1

  公开（公告）日：2004-02-19

  Methods for preventing or for treating benzodiazepine site (BZD-S) associated syndromes comprising administering 2′ hydroxyflavone and flavone derivatives thereof which contain a hydroxyl group at the 2′ position to a patient in need thereof in an effective dose. Methods for extracting certain of the compounds from plant material are also described.

  预防或治疗苯并二氮杂卓部位（BZD-S）相关综合症的方法，包括以有效剂量给需要的病人服用2′羟基黄酮及其黄酮衍生物，这些衍生物在2′位置含有羟基。还描述了从植物材料中提取某些化合物的方法。
• Gallagher et al., Journal of the Chemical Society, 1953, p. 3770,3777
  作者：Gallagher et al.

  DOI：——

  日期：——