1-[(3aR,5R,6S,6aR)-6-methoxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-3-azidopropan-2-ol | 1445950-58-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(3aR,5R,6S,6aR)-6-methoxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-3-azidopropan-2-ol
• CAS: 1445950-58-2
• 化学式: C₁₁H₁₉N₃O₅
• 分子量: 273.289
• InChiKey: GJMOGHGCBCAUQO-JNSGDMPLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  艾日布林中间体 在 (R,R)-Salen-Cr(II) 、 间氯过氧苯甲酸 作用下， 以 甲基叔丁基醚 为溶剂， 反应 72.0h， 生成 ((1-azido-3-((3aR,5R,6S,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)propan-2-yl)oxy)trimethylsilane 、 1-[(3aR,5R,6S,6aR)-6-methoxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]-3-azidopropan-2-ol
  参考文献：
  名称：

  [EN] 2-((2S,3S,4R,5R)-5-((S)-3-AMINO-2-HYDROXYPROP-1-YL)-4-METHOXY-3-(PHENYLSULFONYLMETHYL)TETRAHYDROFURAN-2-YL)ACETALDEHYDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
  [FR] DÉRIVÉS DE 2-((2S,3S,4R,5R)-5-((S)-3-AMINO-2-HYDROXYPROP-1-YL)-4-MÉTHOXY-3-(PHÉNYLSULFONYLMÉTHYL)TÉTRAHYDROFURANE-2-YL)ACÉTALDÉHYDE ET PROCÉDÉ POUR LEUR PRÉPARATION

  摘要：

  下面显示的是一种化合物的化学式1，其中R1、R2、R3、R4、R5、R6和R7如本文所述。此外，还披露了一种制备化合物的方法，以及其中使用的中间体。化合物的化学式1可用于制备halichondrin类似物，如厄立必林。

  公开号：

  WO2013097042A1

文献信息

• [EN] CRYSTALLINE DERIVATIVES OF (S)-1-((2R,3R,4S,5S)-5-ALLYL-3-METHOXY-4-(TOSYLMETHYL)TETRAHYDROFURAN-2-YL)-3-AMINOPROPAN-2-OL<br/>[FR] DÉRIVÉS CRISTALLINS DE (S)-1-((2R,3R,4S,5S)-5-ALLYL-3-MÉTHOXY-4-(TOSYLMÉTHYL)TÉTRAHYDROFURAN-2-YL)-3-AMINOPROPAN-2-OL
  申请人：ALPHORA RES INC

  公开号：WO2015131286A1

  公开（公告）日：2015-09-11

  Disclosed are salts of a compound of formula 1, as shown below, where R1, R2, R3, R4, R5, R6 and R7 are as described herein. Also, disclosed is a process for the preparation of the salts of the compounds of formula 1, and intermediates used therein. The salts of the compound of formula 1 can be useful for preparation of halichondrin analogs such as eribulin.

  本文揭示了化合物的盐，其化学式如下，其中R1、R2、R3、R4、R5、R6和R7如本文所述。此外，还揭示了制备化合物盐的方法以及其中使用的中间体。化合物的盐可以用于制备类似halichondrin的类似物，如厄立布林。
• SYNTHETIC PROCESS FOR PREPARATION OF MACROCYCLIC C1-KETO ANALOGS OF HALICHONDRIN B AND INTERMEDIATES USEFUL THEREIN
  申请人：ALPHORA RESEARCH INC.

  公开号：US20150065733A1

  公开（公告）日：2015-03-05

  Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 7′ , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 are as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed.

  本文披露了一种公式1的化合物，或其药学上可接受的盐，其中R1、R2、R3、R4、R5、R6、R7、R7'、R8、R9、R10、R11、R12和R13如本文所披露。同时，本文还披露了制备公式1的化合物或其药学上可接受的盐的方法及其中使用的中间体。公式1的化合物可用于制备类海绵毒素类似物，如依杜波林；同时还披露了从公式1的化合物制备依杜波林的方法。
• EP2797945B1
  申请人：——

  公开号：EP2797945B1

  公开（公告）日：2016-03-16
• 2-((2S,3S,4R,5R)-5-((S)-3-AMINO-2-HYDROXYPROP-1-YL)-4-METHOXY-3-(PHENYLSULFONYLMETHYL)TETRAHYDROFURAN-2-YL)ACETALDEHYDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
  申请人：ALPHORA RESEARCH INC.

  公开号：US20150011776A1

  公开（公告）日：2015-01-08

  Disclosed is a compound of formula 1, as shown below, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as described herein. Also, disclosed is a process for the preparation of compounds of formula 1, and intermediates used therein. The compound of formula 1 can be useful for preparation of halichondrin analogs such as Eribulin.
• Crystalline derivatives of (S)-1-((2R,3R,4S,5S)-5-allyl-3-methoxy-4-(tosylmethyl)tetrahydrofuran-2-YL)-3-aminopropan-2-ol
  申请人：Alphora Research Inc.

  公开号：US20170066735A1

  公开（公告）日：2017-03-09

  Disclosed are salts of a compound of formula 1, as shown below, where R 1 , R 2 , R 3 , R 4 ′ R 5 , R 6 and R 7 are as described herein. Also, disclosed is a process for the preparation of the salts of the compounds of formula 1, and intermediates used therein. The salts of the compound of formula 1 can be useful for preparation of halichondrin analogs such as eribulin.