1-(4-甲氧基苯基)-5-甲基-1H-吡唑 | 187998-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-(4-甲氧基苯基)-5-甲基-1H-吡唑
• 英文名称: ethyl 1-(4-methoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylate
• 英文别名: ethyl 5-methyl-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylate；ethyl 1-(4-methoxyphenyl)-5-methylpyrazole-4-carboxylate
• CAS: 187998-66-9
• 化学式: C₁₄H₁₆N₂O₃
• 分子量: 260.293
• InChiKey: APRSCISRACOKII-UHFFFAOYSA-N

物化性质

• 熔点：
  63-65 °C
• 沸点：
  374.0±32.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  53.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-甲氧基苯基)-5-甲基-1H-吡唑 在 氯化亚砜 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 1.0h， 生成 1-(4-甲氧基苯基)-5-甲基吡唑-4-羰酰氯
  参考文献：
  名称：

  AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

  摘要：

  公开号：

  EP1176140B1
• 作为产物：
  描述：

  (4-甲氧基苯基)偶氮-4-甲基苯基砜 、 ethyl 3-(tert-butoxycarbonyloxy)-2-methylenebutanoate 在 三丁基膦 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以96%的产率得到1-(4-甲氧基苯基)-5-甲基-1H-吡唑
  参考文献：
  名称：

  ⁿBu₃P-Catalyzed Desulfonylative [3 + 2] Cycloadditions of Allylic Carbonates with Arylazosulfones to Pyrazole Derivatives

  摘要：

  Highly efficient (Bu3P)-Bu-n-catalyzed desulfonylative [3 + 2] cycloadditions of allylic carbonates with arylazosulfones were developed for the synthesis of pyrazole derivatives. The reactions proceed smoothly under mild conditions to generate corresponding annulation products in good to excellent yields.

  DOI：

  10.1021/ol503735c

文献信息

• Catalyst-free one-pot synthesis of 1,4,5-trisubstituted pyrazoles in 2,2,2-trifluoroethanol
  作者：Heshmatollah Alinezhad、Mahmood Tajbakhsh、Mahboobeh Zare

  DOI：10.1016/j.jfluchem.2011.07.014

  日期：2011.11

  A simple, efficient and three component one-pot synthesis of 1,4,5-trisubstituted pyrazoles by condensation of β-dicarbonyls, N,N-dimethylformamide dimethyl acetal (DMFDMA) and hydrazine derivatives in 2,2,2-trifluoroethanol without using any catalyst and activation, is described.

  通过在不使用2,2,2-三氟乙醇的条件下将β-二羰基，N，N-二甲基甲酰胺二甲基乙缩醛（DMFDMA）和肼衍生物缩合的简单，有效的三组分一锅法合成1,4,5-三取代的吡唑描述了任何催化剂和活化。
• AMIDE DERIVATIVE AND USE THEREOF
  申请人：Ushio Hiroyuki

  公开号：US20130211075A1

  公开（公告）日：2013-08-15

  The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.

  本发明涉及一种新型酰胺衍生物。更具体地说，本发明提供了一种药用剂，可用作依赖于T细胞产生细胞因子的疾病的预防或治疗剂，该药用剂包括酰胺衍生物或其药理学上可接受的盐或该衍生物或药理学上可接受的盐的溶剂的溶剂作为活性成分。提供的是由通式(I)所表示的酰胺衍生物[其中每个符号如描述中所定义]或其药理学上可接受的盐，或该衍生物或药理学上可接受的盐的溶剂。
• Isoquinoline and quinazoline derivatives having a combined 5HT1A, 5HT1B, and 5HT1D receptor activity
  申请人：Gaster Mary Laramie

  公开号：US20050239797A1

  公开（公告）日：2005-10-27

  The invention relates to novel isoquinoline and quinazoline derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.

  本发明涉及具有药理活性的新异喹啉和喹唑啉衍生物，其制备方法，含有它们的组合物以及它们在治疗各种疾病中的应用。
• N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia
  申请人：Pfizer Inc.

  公开号：US20030149043A1

  公开（公告）日：2003-08-07

  NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

  NHE-1抑制剂，使用这种NHE-1抑制剂的方法以及含有这种NHE-1抑制剂的制药组合物。NHE-1抑制剂对于减少组织缺血引起的组织损伤是有用的。
• Amide derivative and use thereof
  申请人：Ushio Hiroyuki

  公开号：US09150555B2

  公开（公告）日：2015-10-06

  The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.

  本发明涉及一种新型酰胺衍生物。更具体地说，本发明提供了一种药物剂，其可作为预防或治疗疾病的药物剂，依赖于T细胞产生细胞因子，并包括酰胺衍生物或其药理学上可接受的盐或衍生物或药理学上可接受的盐的溶剂作为活性成分。提供了一种由通式（I）表示的酰胺衍生物[其中每个符号如定义中所述]或其药理学上可接受的盐，或其衍生物或药理学上可接受的盐的溶剂。