Prop-2-yn-1-yl 3-(2-methoxyphenyl)prop-2-enoate | 112111-86-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Prop-2-yn-1-yl 3-(2-methoxyphenyl)prop-2-enoate
• 英文别名: prop-2-ynyl 3-(2-methoxyphenyl)prop-2-enoate
• CAS: 112111-86-1
• 化学式: C₁₃H₁₂O₃
• 分子量: 216.236
• InChiKey: IWKMVHWDKYEIBQ-UHFFFAOYSA-N

物化性质

• 熔点：
  86-87 °C
• 沸点：
  333.6±27.0 °C(Predicted)
• 密度：
  1.131±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-azidobenzonitrile 、 Prop-2-yn-1-yl 3-(2-methoxyphenyl)prop-2-enoate 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 水 、 丙酮 为溶剂， 生成
  参考文献：
  名称：

  An efficient protocol for domino one pot synthesis of 1,2,3-triazoles from natural organic acids and phenols

  摘要：

  An efficient three-component protocol was developed for the one-pot synthesis of 1,2,3-triazoles from natural product based acids and phenols, using CuSO4-sodium ascorbate catalyst system. The method is general and showed considerable synthetic advantage giving products in excellent yields with a wide substrate scope. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.09.123
• 作为产物：
  描述：

  2-甲氧基肉桂酸 、 3-溴丙炔 在 三乙胺 作用下， 以 水 、 丙酮 为溶剂， 生成 Prop-2-yn-1-yl 3-(2-methoxyphenyl)prop-2-enoate
  参考文献：
  名称：

  An efficient protocol for domino one pot synthesis of 1,2,3-triazoles from natural organic acids and phenols

  摘要：

  An efficient three-component protocol was developed for the one-pot synthesis of 1,2,3-triazoles from natural product based acids and phenols, using CuSO4-sodium ascorbate catalyst system. The method is general and showed considerable synthetic advantage giving products in excellent yields with a wide substrate scope. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.09.123

文献信息

• An efficient protocol for domino one pot synthesis of 1,2,3-triazoles from natural organic acids and phenols
  作者：Nisar A. Dangroo、Alamgir A. Dar、Bashir Ahmad Dar

  DOI：10.1016/j.tetlet.2014.09.123

  日期：2014.12

  An efficient three-component protocol was developed for the one-pot synthesis of 1,2,3-triazoles from natural product based acids and phenols, using CuSO4-sodium ascorbate catalyst system. The method is general and showed considerable synthetic advantage giving products in excellent yields with a wide substrate scope. (C) 2014 Elsevier Ltd. All rights reserved.