2-Methyl-4-nitro-1-propylimidazole | 135009-56-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Methyl-4-nitro-1-propylimidazole
• CAS: 135009-56-2
• 化学式: C₇H₁₁N₃O₂
• 分子量: 169.183
• InChiKey: JVOWBYXPAGITNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Methyl-4-nitro-1-propylimidazole 在 硝酸 、 溶剂黄146 、 potassium iodide 作用下， 反应 4.0h， 以90%的产率得到5-Iodo-2-methyl-4-nitro-1-propyl-1H-imidazole
  参考文献：
  名称：

  Electrophilic Iodination of 4-Nitroimidazoles - a New High Yielding Method for the Synthesis of 4-Nitro-5-iodoimidazoles

  摘要：

  Electrophilic iodination of 4-nitroimidazoles employing the system KI-HN3-AcOH provided for the synthesis of 4-nitro-5-iodoimidazoles in high yields. With 2-unsubstituted-4-nitroimidazoles, 2,5-diiodo-4-nitro-imidazoles were obtained.

  DOI：

  10.1080/00397919408011194
• 作为产物：
  描述：

  1,3,2-二噁唑噻吩-2,2-二氧化物 、 1-acetoxymethyl-2-methyl-4-nitroimidazole 生成 2-Methyl-4-nitro-1-propylimidazole
  参考文献：
  名称：

  MASSONNEAU, V.;MANDARD, B.;MULHAUSER, M.;PERRIER, G., 8TH INT. IUPAC CONF. ORG. SYNTH., HELSINKI, 23-27 JULY, 1990. ABSTR., HEL+

  摘要：

  DOI：

文献信息

• Intermediates for imidazonaphthyridines
  申请人：Gerster F. John

  公开号：US20080091010A1

  公开（公告）日：2008-04-17

  Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.

  Imidazonaphthyridine和tetrahydroimidazonaphthyridine化合物能够诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。这些化合物具有抗病毒和抗肿瘤的特性。本文披露了制备这些化合物及其中间体的方法。
• IMIDAZONAPHTHYRIDINES
  申请人：Lindstrom J. Kyle

  公开号：US20070167481A1

  公开（公告）日：2007-07-19

  Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.

  Imidazonaphthyridine和tetrahydroimidazonaphthyridine化合物能够诱导干扰素和肿瘤坏死因子等细胞因子的生物合成。这些化合物具有抗病毒和抗肿瘤的特性。本发明还公开了制备这些化合物和在制备这些化合物中有用的中间体的方法。
• EXPANDED THERAPEUTIC POTENTIAL IN NITROHETEROARYL ANTIMICROBIALS
  申请人：The Regents of the University of California

  公开号：US20160244435A1

  公开（公告）日：2016-08-25

  Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to imidazole, thiazole, and furan derivatives and their use as therapeutic agents.

  本文披露了抗微生物化合物组成物、制药组合物、其使用和制备方法。其中一些实施例涉及咪唑、噻唑和呋喃衍生物及其作为治疗剂的使用。
• Rao, A. K. S. Bhujanga; Rao, C. Gundu; Singh, B. B., Journal of the Chemical Society. Perkin transactions I, 1994, # 17, p. 2399 - 2402
  作者：Rao, A. K. S. Bhujanga、Rao, C. Gundu、Singh, B. B.

  DOI：——

  日期：——
• A Facile High Yielding Method for Synthesis of N-Alkyl-4-Nitroimidazoles
  作者：A. K. S. Bhujanga Rao、C. Gundu Rao、B. B. Singh

  DOI：10.1080/00397919108016766

  日期：1991.2

  A high yielding and fast reaction for the synthesis of a variety of N-alkyl 4-nitroimidazoles has been described. This method involves reaction of 2-methyl-4(5)-nitro-1H-imidazole with suitable alkyl halides in K2CO3/DMF at 110-120-degrees-C.