2,4-dideoxy-3,5-O-[(4-methoxyphenyl)methylene]-2,4-dimethyl-L-arabinitol | 517906-83-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-dideoxy-3,5-O-[(4-methoxyphenyl)methylene]-2,4-dimethyl-L-arabinitol
• 英文别名: (2S)-2-[(4R,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]propan-1-ol
• CAS: 517906-83-1
• 化学式: C₁₅H₂₂O₄
• 分子量: 266.337
• InChiKey: MLMQKEIAAYXNIQ-YNWUBMQCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-dideoxy-3,5-O-[(4-methoxyphenyl)methylene]-2,4-dimethyl-L-arabinitol 在 草酰氯 、 二甲基亚砜 作用下， 以 二氯甲烷 、 溶剂黄146 、 甲苯 、 乙腈 为溶剂， 反应 17.25h， 生成 (2R,4S,5S)-5-((4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)hexane-2,4-diol
  参考文献：
  名称：

  Chivosazole A-阐明绝对和相对构型。

  摘要：

  DOI：

  10.1002/anie.200605198
• 作为产物：
  描述：

  (2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol 在 锂硼氢 、 草酰氯 、 4 A molecular sieve 、 三氟甲磺酸二丁硼 、 二甲基亚砜 、 三乙胺 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 8.5h， 生成 2,4-dideoxy-3,5-O-[(4-methoxyphenyl)methylene]-2,4-dimethyl-L-arabinitol
  参考文献：
  名称：

  Chivosazole A-阐明绝对和相对构型。

  摘要：

  DOI：

  10.1002/anie.200605198

文献信息

• Certain substituted polyketides, pharmac eutical compositions containing them and their use in treating tumors
  申请人：——

  公开号：US20030153601A1

  公开（公告）日：2003-08-14

  The present invention relates to certain substituted polyketides of formula I, 1 wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.

  本发明涉及某些取代的多酮类化合物，其公式为I，其中A、B和C定义如下，包含所述化合物的药物组合物，以及使用所述化合物治疗肿瘤的方法。
• Stereoselective Aldol-Type Cyclization Reaction Mediated by Dibutylboron Triflate/Diisopropylethylamine
  作者：Sanjib Das、Lian-Sheng Li、Subhash C. Sinha

  DOI：10.1021/ol036229b

  日期：2004.1.1

  [reaction: see text] Dibutylboron triflate/diisopropylethylamine mediated aldol-type cyclization provides an expedient route for the stereoselective synthesis of cyclic ethers in a single step. The method is highly efficient for the stereoselective synthesis of 4-cis-tetrahydropyranones. The reaction is proposed to proceed via an S(N)1-type mechanism through a chair-like transition state, in which

  [反应：见正文]三氟甲磺酸二丁基硼/二异丙基乙胺介导的醇醛型环化为一步立体异构合成环醚提供了一条方便的途径。该方法对于4-顺式-四氢吡喃酮的立体选择性合成是高效的。提出该反应通过S（N）1型机理通过椅子状过渡态进行，其中两个取代基均占据赤道位置。
• Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
  申请人：——

  公开号：US20040186165A1

  公开（公告）日：2004-09-23

  A compound of the following structure: 1 wherein R 1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R 2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; R a , R b and R c are independently an alkyl group or an aryl group; R d is an alkyl group, an aryl group, an alkoxylalkyl group, —R i SiR a R b R c or a benzyl group, wherein R i is an alkylene group; R e is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NR g R h , wherein R g and R h are independently H, an alkyl group or an aryl group; R 3 is (CH 2 ) n where n is and integer in the range of 0 to 5, —CH 2 CH(CH 3 )—, —CH═CH—, —CH═C(CH 3 )—, or —C≡C—; R 4 is (CH 2 ) p where p is an integer in the range of 4 to 12, —(CHR k1 ) y1 (CHR k2 ) y2 (CHR k3 ) y3 (CHR k4 ) y4 (CHR k5 ) y5 C(R s1 )═C(R s2 )C(R s3 )═C(R s4 )—, —(CHR k1 ) y1 (CHR k2 ) y2 (CHR k3 ) y3 (CHR k4 ) y4 (CHR k5 ) y5 CH(R s1 )CH(R s2 )C(R s3 )═C(R s4 )—, —(CHR k1 ) y1 (CHR k2 ) y2 (CHR k3 ) y3 (CHR k4 ) y4 (CHR k5 ) y5 C(R s1 )═C(R s2 )CH(R s3 )CH(R s4 )—, —(CHR k1 ) y1 (CHR k2 ) y2 (CHR k3 ) y3 (CHR k4 ) y4 (CHR k5 ) y5 CH(R s1 )CH(R s2 )CH(R s3 )CH(R s4 )—, wherein y1 and y2 are 1 and y3, y4 and y5 are independently 0 or 1, R k1 , R k2 , R k3 , R k4 and R k5 are independently H, CH 3 , or OR 2a , and R s1 , R s2 , R s3 , and R s4 are independently H or CH 3 , wherein R 2a is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; and R 5 is H or OR 2b , wherein R 2b is H, an alkyl group, an aryl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; provided that the compound is not dictyostatin 1.

  以下结构的化合物：其中R1为H、烷基、芳基、烯基、炔基或卤素原子；R2为H、烷基、芳基、苄基、三苯甲基、—SiRaRbRc、CH2ORd或CORe；Ra、Rb和Rc独立地为烷基或芳基；Rd为烷基、芳基、烷氧基烷基、—RiSiRaRbRc或苄基，其中Ri为烷基；Re为烷基、烯丙基、苄基、芳基、烷氧基或—NRgRh，其中Rg和Rh独立地为H、烷基或芳基；R3为(CH2)n，其中n为0至5范围内的整数，—CH2CH(CH3)—、—CH═CH—、—CH═C(CH3)—或—C≡C—；R4为(CH2)p，其中p为4至12范围内的整数，—(CHRk1)y1(CHRk2)y2(CHRk3)y3(CHRk4)y4(CHRk5)y5C(Rs1)═C(Rs2)C(Rs3)═C(Rs4)—、—(CHRk1)y1(CHRk2)y2(CHRk3)y3(CHRk4)y4(CHRk5)y5CH(Rs1)CH(Rs2)C(Rs3)═C(Rs4)—、—(CHRk1)y1(CHRk2)y2(CHRk3)y3(CHRk4)y4(CHRk5)y5C(Rs1)═C(Rs2)CH(Rs3)CH(Rs4)—、—(CHRk1)y1(CHRk2)y2(CHRk3)y3(CHRk4)y4(CHRk5)y5CH(Rs1)CH(Rs2)CH(Rs3)CH(Rs4)—，其中y1和y2为1，y3、y4和y5独立地为0或1，Rk1、Rk2、Rk3、Rk4和Rk5独立地为H、CH3或OR2a，而Rs1、Rs2、Rs3和Rs4独立地为H或CH3，其中R2a为H、烷基、芳基、苄基、三苯甲基、—SiRaRbRc、CH2ORd或CORe；而R5为H或OR2b，其中R2b为H、烷基、芳基、苄基、三苯甲基、—SiRaRbRc、CH2ORd或CORe；但该化合物不是二叉鞘菌素1。
• ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF
  申请人：CURRAN DENNIS P.

  公开号：US20090036691A1

  公开（公告）日：2009-02-05

  A compound of the following structure: wherein R 1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R 2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; R a , R b and R c are independently an alkyl group or an aryl group; R d is an alkyl group, an aryl group, an alkoxylalkyl group, —R i SiR a R b R c or a benzyl group, wherein R i is an alkylene group; R e is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NR g R h , wherein R g and R h are independently H, an alkyl group or an aryl group; R 3 is (CH 2 ) n where n is and integer in the range of 0 to 5, —CH 2 CH(CH 3 )—, —CH═CH—, —CH═C(CH 3 )—, or —C≡C—; R 4 , wherein y1 and y2 are 1 and y3, y4 and y5 are independently 0 or 1, R k1 , R k2 , R k3 , R k4 and R k5 are independently H, CH 3 , or OR 2a , and R s1 , R s2 , R s3 , and R s4 are independently H or CH 3 , wherein R 2a is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; and R 5 is H or OR 2b , wherein R 2b is H, an alkyl group, an aryl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e .

  以下为结构式的化合物： 其中R1为H、烷基、芳基、烯基、炔基或卤素原子； R2为H、烷基、芳基、苯甲基、三苯甲基、—SiRaRbRc、CH2ORd或CORe； Ra、Rb和Rc独立地为烷基或芳基； Rd为烷基、芳基、烷氧基烷基、—RiSiRaRbRc或苯甲基，其中Ri为烷基； Re为烷基、烯丙基、苯甲基、芳基、烷氧基或—NRgRh，其中Rg和Rh独立地为H、烷基或芳基； R3为(CH2)n，其中n为0至5的整数，—CH2CH(CH3)—、—CH═CH—、—CH═C(CH3)—或—C≡C—； R4为H或OR2b，其中y1和y2为1，y3、y4和y5独立地为0或1，Rk1、Rk2、Rk3、Rk4和Rk5独立地为H、CH3或OR2a，而Rs1、Rs2、Rs3和Rs4独立地为H或CH3，其中R2a为H、烷基、芳基、苯甲基、三苯甲基、—SiRaRbRc、CH2ORd或CORe；而R2b为H、烷基、芳基、苯甲基、三苯甲基、—SiRaRbRc、CH2ORd或CORe。
• Discodermolide analogues and their pharmaceutical use
  申请人：Novartis AG

  公开号：EP1312608A2

  公开（公告）日：2003-05-21

  The present invention relates to certain discodermolide analogues of formula I, wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.

  本发明涉及某些式 I 的盘多莫内酯类似物、 其中 A、B 和 C 如本文所定义、含有所述化合物的药物组合物，以及所述化合物在治疗肿瘤中的用途。