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乙酮,1-(5-乙基-2,4-二羟基苯基)-2-(1-甲基-1H-苯并咪唑-2-基)- | 139399-42-1

中文名称
乙酮,1-(5-乙基-2,4-二羟基苯基)-2-(1-甲基-1H-苯并咪唑-2-基)-
中文别名
——
英文名称
α-(1-methyl-2-benzimidazolyl)-2,4-dihydroxy-5-ethylacetophenone
英文别名
2-(5-ethyl-2,4-dihydroxyphenacyl)-1-methylbenzimidazole;1-(5-ethyl-2,4-dihydroxyphenyl)-2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-one;1-(5-ethyl-2,4-dihydroxyphenyl)-2-(1-methylbenzimidazol-2-yl)ethanone
乙酮,1-(5-乙基-2,4-二羟基苯基)-2-(1-甲基-1H-苯并咪唑-2-基)-化学式
CAS
139399-42-1
化学式
C18H18N2O3
mdl
MFCD00525314
分子量
310.353
InChiKey
KAIMAPGPSLRDDN-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.4
  • 重原子数:
    23
  • 可旋转键数:
    4
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.22
  • 拓扑面积:
    75.4
  • 氢给体数:
    2
  • 氢受体数:
    4

SDS

SDS:ab32b71159747427f7969378060e2e93
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反应信息

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文献信息

  • Cyclic Carboxylic Anhydrides as New Reagents for Formation of Chromone Ring
    作者:Mykhaylo S. Frasinyuk、Svitlana P. Bondarenko、Nataliia V. Gorbulenko、Alexander V. Turov、Volodymyr P. Khilya
    DOI:10.1002/jhet.1721
    日期:2014.5
    ring‐opening was exploited in a reaction with 2'‐hydroxy‐α‐heteroarylacetophenones leading to the formation of chromones. New simple method was developed for the synthesis of 2‐(ω‐carboxyalkyl)‐3‐heteroarylchromones without protecting either the phenolic or the carboxylic groups. Treatment with hydrazine led to the formation of 3(5)‐(ω‐carboxyalkyl)‐5(3)‐(2,4‐dihydroxyphenyl)‐4‐heteroarylpyrazoles.
    在与2'-羟基-α-杂芳基苯乙酮反应导致色酮形成的过程中,利用了环状羧酸酐发生开环的倾向。开发了一种新的简单方法来合成2-(ω-羧烷基)-3-杂芳基色酮,而又不保护酚基或羧基。用肼处理导致形成3(5)-(ω-羧烷基)-5(3)-(2,4-二羟基苯基)-4-杂芳基吡唑。
  • Chemistry of hetero analogs of isoflavones 25. Synthesis of 2-alkyl-3-(2-benzimidazolyl)-chromones
    作者:M. S. Frasinyuk、V. P. Khilya
    DOI:10.1007/s10593-008-0015-7
    日期:2008.1
    2-Alkyl-3-(1-methyl-2-benzimidazolyl)-7-acyloxychromones were synthesized by the reaction of substituted or unsubstituted 2-(2,4-dihydroxyphenacyl)-1-methylbenzimidazoles with the acid chlorides and anhydrides of carboxylic acids. The products were converted into 2-alkyl-7-hydroxychromones as a result of acid hydrolysis.
  • Novel therapeutic target for protozoal diseases
    申请人:Rathore Dharmender
    公开号:US20070148185A1
    公开(公告)日:2007-06-28
    A novel Hemozoin Detoxification Protein (HDP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. HDP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, HDP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on HDP, or antigenic epitopes of HDP, either alone or in combination with other parasite antigens. Methods for the development and use of compounds that inhibit the catalytic activity of HDP, and diagnostic and laboratory methods utilizing HDP are also provided. HDP is also referred to herein as Fasciclin Related Adhesive Protein (FRAP).
  • [EN] A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES<br/>[FR] UNE NOUVELLE CIBLE THÉRAPEUTIQUE POUR LES MALADIES À PROTOZOAIRE
    申请人:VIRGINIA TECH INTELL PROP
    公开号:WO2007047579A2
    公开(公告)日:2007-04-26
    [EN] A novel Hemozoin Detoxification Protein (HDP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. HDP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, HDP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on HDP, or antigenic epitopes of HDP, either alone or in combination with other parasite antigens. Methods for the development and use of compounds that inhibit .the catalytic activity of HDP, and diagnostic and laboratory methods utilizing HDP are also provided. HDP is also referred to herein as Fasciclin Related Adhesive Protein (FRAP).
    [FR] L'invention concerne une nouvelle protéine de désintoxication de l'hémozoïne (PDH) de plasmodium et de parasites apparentés, comme cible pour intervention thérapeutique dans des maladies causées par lesdits parasites. La PDH s'est avéré jouer un rôle critique dans l'adhésion à des, ou l'invasion de, cellules hôtes par le parasite. En outre, La PDH catalyse la neutralisation de l'hème par le parasite, en encourageant sa polymérisation en hémozoïne. La présente invention concerne des méthodes et des compositions pour des thérapies basées sur l'administration de vaccins à base de protéine, d'ADN ou de cellules, et/ou d'anticorps basés sur la PDH ou d'épitopes antigènes de la PDH, seuls ou en combinaison avec d'autres antigènes de parasites. L'invention concerne aussi des méthodes pour développer et utiliser des composés qui inhibent l'activité catalytique de la PDH, et des méthodes diagnostiques et de laboratoire utilisant la PDH. On fait également référence ici à la PDH comme protéine adhésive apparentée à la fascicline (FRAP : Fasciclin Related Adhesive Protein).
  • Chemistry of the heteroanalogs of isoflavones. 20. Benzimidazole analogs of isoflavones
    作者:M. S. Frasinyuk、N. V. Gorbulenko、V. P. Khilya
    DOI:10.1007/bf02253223
    日期:1997.9
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