lithium N,O-bis(trifluoroacetyl)hydroxylamine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: lithium N,O-bis(trifluoroacetyl)hydroxylamine
• 英文别名: lithium;2,2,2-trifluoro-N-(2,2,2-trifluoroacetyl)oxyethanimidate
• 化学式: C₄F₆NO₃*Li
• 分子量: 230.98
• InChiKey: UHBPIBLXBJPHKO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.53
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  lithium N,O-bis(trifluoroacetyl)hydroxylamine 、 甲基异丙基硫醚 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 乙二醇二甲醚 为溶剂， 以76%的产率得到N-trifluoroacetyl-methyl isopropylsulfilimine
  参考文献：
  名称：

  N,O-Bis(trifluoroacetyl)hydroxylamine as a Useful Electrophilic Nitrogen Source:  Catalytic Synthesis of N-(Trifluoroacetyl)sulfilimines

  摘要：

  [GRAPHICS]In the presence of catalytic quantites of Cu(OTf)(2) the novel hydroxamic acid anhydride salt functions competently in the trifluoroacetamidation of sulfides to afford N-(trifluoroacetyl)sulfilimines. The salient features of this salt include its ease of synthesis from the inexpensive, commercially available starting materials trifluoroacetic anhydride and hydroxylamine hydrochloride.

  DOI：

  10.1021/ol9900515
• 作为产物：
  描述：

  N,O-双(三氟乙酰基)羟胺 在 叔丁基锂 作用下， 以 乙醚 、 正戊烷 为溶剂， 以91%的产率得到lithium N,O-bis(trifluoroacetyl)hydroxylamine
  参考文献：
  名称：

  N,O-Bis(trifluoroacetyl)hydroxylamine as a Useful Electrophilic Nitrogen Source:  Catalytic Synthesis of N-(Trifluoroacetyl)sulfilimines

  摘要：

  [GRAPHICS]In the presence of catalytic quantites of Cu(OTf)(2) the novel hydroxamic acid anhydride salt functions competently in the trifluoroacetamidation of sulfides to afford N-(trifluoroacetyl)sulfilimines. The salient features of this salt include its ease of synthesis from the inexpensive, commercially available starting materials trifluoroacetic anhydride and hydroxylamine hydrochloride.

  DOI：

  10.1021/ol9900515

文献信息

• <i>N</i>,<i>O</i>-Bis(trifluoroacetyl)hydroxylamine as a Useful Electrophilic Nitrogen Source:  Catalytic Synthesis of <i>N</i>-(Trifluoroacetyl)sulfilimines
  作者：C. S. Tomooka、D. D. LeCloux、H. Sasaki、E. M. Carreira

  DOI：10.1021/ol9900515

  日期：1999.7.1

  [GRAPHICS]In the presence of catalytic quantites of Cu(OTf)(2) the novel hydroxamic acid anhydride salt functions competently in the trifluoroacetamidation of sulfides to afford N-(trifluoroacetyl)sulfilimines. The salient features of this salt include its ease of synthesis from the inexpensive, commercially available starting materials trifluoroacetic anhydride and hydroxylamine hydrochloride.