2-(3-Hydroxy-3-methylbut-1-EN-1-YL)phenol | 17235-14-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: 2-(3-Hydroxy-3-methylbut-1-EN-1-YL)phenol
• 英文别名: 2-(3-hydroxy-3-methylbut-1-enyl)phenol
• CAS: 17235-14-2
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: CDSUBTCQAOYVRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2907299090

反应信息

• 作为反应物：
  描述：

  2-(3-Hydroxy-3-methylbut-1-EN-1-YL)phenol 在 silica gel 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以96%的产率得到2,2,-二甲基-2H-苯并吡喃
  参考文献：
  名称：

  Efficient One-Pot Synthesis of 2,2-Dimethyl-2H-chromenes via Pd(II)-Catalyzed Coupling and SiO₂-Promoted Condensation of o-Halophenols with 2-Methyl-3-buten-2-ol

  摘要：

  An efficient synthesis of 2,2-dimethyl-2H-chromenes was accomplished by Pd(II)-catalyzed coupling and SiO2-promoted condensation of o-halophenols with 2-methyl-3-buten-2-ol (1,1-dimethylallyl alcohol) in one pot. The method is very general and can be useful for the synthesis of some natural 2,2-dimethyl-2H-chromenes.

  DOI：

  10.1080/00397911.2015.1056371
• 作为产物：
  描述：

  1,1-二甲基-2-丙烯基乙酸酯 、 2-碘苯酚 在 palladium diacetate 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以10%的产率得到2-(3-Hydroxy-3-methylbut-1-EN-1-YL)phenol
  参考文献：
  名称：

  Efficient One-Pot Synthesis of 2,2-Dimethyl-2H-chromenes via Pd(II)-Catalyzed Coupling and SiO₂-Promoted Condensation of o-Halophenols with 2-Methyl-3-buten-2-ol

  摘要：

  An efficient synthesis of 2,2-dimethyl-2H-chromenes was accomplished by Pd(II)-catalyzed coupling and SiO2-promoted condensation of o-halophenols with 2-methyl-3-buten-2-ol (1,1-dimethylallyl alcohol) in one pot. The method is very general and can be useful for the synthesis of some natural 2,2-dimethyl-2H-chromenes.

  DOI：

  10.1080/00397911.2015.1056371

文献信息

• Efficient One-Pot Synthesis of 2,2-Dimethyl-2<i>H</i>-chromenes via Pd(II)-Catalyzed Coupling and SiO₂-Promoted Condensation of <i>o</i>-Halophenols with 2-Methyl-3-buten-2-ol
  作者：Jia Ti Tee、Marzieh Yaeghoobi、Chin Fei Chee、Noorsaadah Abd. Rahman

  DOI：10.1080/00397911.2015.1056371

  日期：2015.8.18

  An efficient synthesis of 2,2-dimethyl-2H-chromenes was accomplished by Pd(II)-catalyzed coupling and SiO2-promoted condensation of o-halophenols with 2-methyl-3-buten-2-ol (1,1-dimethylallyl alcohol) in one pot. The method is very general and can be useful for the synthesis of some natural 2,2-dimethyl-2H-chromenes.