反-N,N,N',N'-四甲基-2-丁烯-1,4-二胺 | 111-52-4

• 物质功能分类: 有机原料 - 氨基化合物 - 无环单胺、多胺及其衍生物和盐
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 反-N,N,N',N'-四甲基-2-丁烯-1,4-二胺
• 中文别名: 反式-N,N,N′,N′-四甲基-2-丁烯-1,4-二胺；反-N,N,N,N-四甲基-2-丁烯-1,4-二胺；N,N,N',N'-四甲基-2-丁烯-1,4-二胺
• 英文名称: N,N,N',N'-tetramethyl-2-butene-1,4-diamine
• 英文别名: trans-N,N,N',N'-tetramethyl-2-butene-1,4-diamine；N,N,N',N'-Tetramethylbut-2t-en-1,4-diamin；N,N,N',N'-tetramethyl-1,4-diamino-2-butene；1,4-bis-(dimethylamino)-2-butene；tetra-N-methyl-but-2t-enediyldiamine；Tetra-N-methyl-but-2t-endiyldiamin；(E)-N,N,N',N'-tetramethylbut-2-ene-1,4-diamine
• CAS: 111-52-4
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: KUEDAAUECWBMLW-AATRIKPKSA-N

物化性质

• 沸点：
  172-173 °C/723 mmHg (lit.)
• 密度：
  0.82 g/mL at 25 °C (lit.)
• 闪点：
  123 °F
• 稳定性/保质期：

  在常温常压下稳定，应避免与强氧化剂和强酸接触。

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  C
• 安全说明：
  S16,S26,S36/37/39,S45
• 危险类别码：
  R10
• WGK Germany：
  3
• 危险标志：
  GHS02,GHS05
• 危险品运输编号：
  UN 2734 8
• 危险性描述：
  H226,H314
• 危险性防范说明：
  P280,P305 + P351 + P338,P310
• 包装等级：
  II
• 危险类别：
  8,3
• 储存条件：
  常温下应密封保存于阴凉通风处。

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
: trans-N,N,N′,N′-Tetramethyl-2-butene-1,4-diamine
Product name
CAS-No. : 111-52-4
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Flammable liquids (Category 3)
Skin corrosion (Category 1B)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Flammable. Causes burns.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Danger
Hazard statement(s)
H226 Flammable liquid and vapour.
H314 Causes severe skin burns and eye damage.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R10 Flammable.
R34 Causes burns.
S-phrase(s)
S16 Keep away from sources of ignition - No smoking.
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S45 In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C8H18N2
Molecular Weight : 142,24 g/mol
Component Concentration
(E)-N,N,N',N'-Tetramethylbut-2-ene-1,4-diamine
CAS-No. 111-52-4 -
EC-No. 203-879-0

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a
physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and
skin., Cough, Shortness of breath, Headache, Nausea
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or
spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of
water.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Store under inert gas.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
tested and approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
of protective equipment must be selected according to the concentration and amount of the
dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and 172 - 173 °C at 964 hPa - lit.
boiling range
g) Flash point 54,44 °C - closed cup
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density 0,82 g/cm3 at 25 °C
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract.
Ingestion May be harmful if swallowed. Causes burns.
Skin May be harmful if absorbed through skin. Causes skin burns.
Eyes Causes eye burns.
Signs and Symptoms of Exposure
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and
skin., Cough, Shortness of breath, Headache, Nausea
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company. Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: 2734 IMDG: 2734 IATA: 2734
UN proper shipping name
ADR/RID: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. ((E)-N,N,N',N'-Tetramethylbut-2-ene-
1,4-diamine)
IMDG: AMINES, LIQUID, CORROSIVE, FLAMMABLE, N.O.S. ((E)-N,N,N',N'-Tetramethylbut-2-ene-
1,4-diamine)
IATA: Amines, liquid, corrosive, flammable, n.o.s. ((E)-N,N,N',N'-Tetramethylbut-2-ene-1,4-diamine)
Transport hazard class(es)
ADR/RID: 8 (3) IMDG: 8 (3) IATA: 8 (3)
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

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Section 16. OTHER INFORMATION
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

反应信息

• 作为反应物：
  描述：

  反-N,N,N',N'-四甲基-2-丁烯-1,4-二胺 、 乙酰胺,2-溴-N-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)- 以 乙醚 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Enhanced activity of fluorinated quaternary ammonium surfactants against Pseudomonas aeruginosa

  摘要：

  A novel series of fluorinated quaternary bisammonium surfactants has been synthesized in view to optimize their antimicrobial activities against Pseudomonas aeruginosa. As compared with commercial references, most of the new surfactants synthesized exhibit an enhanced activity which is discussed as a function of the nature of the spacer group between the quaternized nitrogen atoms and of the nature of the connector function between the nitrogen atoms and the perfluorinated carbon chains. It appears that the fluorinated "Gemini" surfactants bearing an amide connector can be an interesting alternative to hydrocarbon ammonium salts as preservatives and disinfectants against R aeruginosa. (c) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.07.032
• 作为产物：
  描述：

  反式-1,4-二氯-2-丁烯 、 二甲胺 在 乙醚 、 苯 作用下， 生成 反-N,N,N',N'-四甲基-2-丁烯-1,4-二胺
  参考文献：
  名称：

  β,γ-Dihalopropylamines. I. 1-Amino-2,3-dichloropropanes and 1,4-Diamino-2,3-dichlorobutanes

  摘要：

  DOI：

  10.1021/ja01611a049

文献信息

• N,N'-alkenylene amine/mercaptotolyl-imidazole blends as high temperature antioxidants for elastomers
  申请人：CIBA-GEIGY AG

  公开号：EP0585202A1

  公开（公告）日：1994-03-02

  Elastomers are very effectively stabilized against thermal and oxidative degradation at elevated temperatures with a blend of an N,N,N',N'-tetrasubstituted 1,4-diamino-2-butene, where the substituents are alkyl, cycloalkyl, aralkyl, aryl or mixtures thereof, in combination with a mercaptoimidazole of formula IV where E is hydrogen, alkyl, cycloalkyl, aryl or phenylalkyl.

  弹性体在高温下通过使用N,N,N',N'-四取代的1,4-二氨基-2-丁烯与一种巯基咪唑的混合物（其中取代基为烷基、环烷基、芳基、苄基或它们的混合物）进行稳定，可以有效防止热氧化降解。
• [EN] POLYMERIC AMMONIUM AND OR PHOSPHONIUM SALTS HAVING ADDED pi-ELECTRONS AND HIGHER MOLECULAR WEIGHT AS ENHANCERS FOR CHEMILUMINESCENT SYSTEMS<br/>[FR] SELS D'AMMONIUM ET/OU DE PHOSPHONIUM POLYMERIQUES AYANT DES ELECTRONS DOLLAR G(P) ADDITIONNES ET DE POIDS MOLECULAIRES PLUS ELEVES EN TANT QU'ACTIVATEURS DE SYSTEMES CHIMILUMINESCENTS
  申请人：GIRI BRIJ PAL

  公开号：WO2003099802A1

  公开（公告）日：2003-12-04

  A compound for enhancing the light output of a chemiluminescent system and, in particular, a stabilized, triggerable 1,2-dioxetane, is obtained by reacting a polyvinylbenzyl halide and a bilinker with either a trisubstituted amine or trisubstituted phosphine. A fluorescent molecule may be attached to polymer along with the trisubstituted amine or trisubstituted phosphine. Also, the benzyl halide may be reacted with a π-electron donor, such as a vinyl naphthalene or vinylanthracene to form a co-polymer which is polymerizable with the trisubstituted amine and/or trisubstituted phosphine. By controlling the reaction parameters it is possible to obtain either a water-soluble or partial water soluble or insoluble compound crosslink polymer.

  通过将聚乙烯苯基卤化物和双联物与三取代胺或三取代膦反应，可以获得一种用于增强化学发光系统光输出的化合物，特别是稳定的、可触发的1,2-二氧杂环丁烷。荧光分子可以与三取代胺或三取代膦一起连接到聚合物上。此外，苯基卤化物可以与π-电子供体（如乙烯基萘或乙烯基蒽）反应，形成与三取代胺和/或三取代膦聚合的共聚物。通过控制反应参数，可以获得水溶性、部分水溶性或不溶性的交联聚合物化合物。
• [EN] OXIDATION OF 2-MERCAPTOETHANOL<br/>[FR] OXYDATION DU 2-MERCAPTOÉTHANOL
  申请人：BASF SE

  公开号：WO2015086565A1

  公开（公告）日：2015-06-18

  The present invention relates to a process for the preparation of bis-(2-hydroxyethyl)-disulfide by oxidizing 2-mercaptoethanol with oxygen in a reaction mixture comprising at least one ho- mogeneously distributed iron comprising salt or complex as catalyst and at least one tertiary amine, to bis-(2-hydroxyethyl)-disulfide, obtainable with the process, and to the use of this bis- (2-hydroxyethyl)-disulfide as intermediate in the manufacture of chemical compounds, such as lubricant additives and in the tertiary oil recovery.

  本发明涉及一种制备双-(2-羟乙基)-二硫化物的方法，该方法通过将2-巯基乙醇与氧气在反应混合物中氧化，其中该混合物包括至少一种均匀分布的铁盐或配合物作为催化剂和至少一种三级胺，得到的产物为双-(2-羟乙基)-二硫化物。本发明还涉及将该双-(2-羟乙基)-二硫化物作为化学化合物的中间体用于制造润滑剂添加剂和三级油回收等方面的用途。
• Hypoxia-Targeted Polymeric Micelles for Cancer Therapy and Imaging
  申请人：Giri, Brij P.

  公开号：EP2777694A1

  公开（公告）日：2014-09-17

  The present invention provides a composition and method for targeting hypoxic tumor areas for detection or treatment or a treatment adjuvant for cancer. Specifically, a hypoxia targeting moiety is conjugated to a polymeric micelle containing imaging agents, therapeutic agents, or therapeutic adjuvants.

  本发明提供了一种用于针对缺氧肿瘤区域进行检测、治疗或作为癌症治疗辅助剂的组合物和方法。具体来说，将一个缺氧靶向基团与含有成像剂、治疗剂或治疗辅助剂的聚合物微胶束结合。
• Internally coordinated organoboranes
  申请人：Lord Corporation

  公开号：US20040242817A1

  公开（公告）日：2004-12-02

  Disclosed are internally coordinated organoboranes as 5, 6, or 7-membered rings formed from an unsaturated amine, amidine, or guanidine and dialkylhydroborane under hydroboration conditions, as well as two-part adhesive or coating kits containing radical polymerizable material and the internally coordinated organoborane. A representative internally coordinated organoborane is: 1

  本发明涉及在氢化硼条件下，从不饱和胺、酰胺或脲和二烷基氢硼烷形成的5、6或7元环的内部配位有机硼化合物，以及包含自由基聚合材料和内部配位有机硼烷的两部分粘合剂或涂料套件。代表性的内部配位有机硼化合物为：1。

表征谱图