乙酰胺,2-溴-N-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)- | 132711-10-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙酰胺,2-溴-N-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-
• 英文名称: 2-bromo-N-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)acetamide
• CAS: 132711-10-5
• 化学式: C₁₀H₇BrF₁₃NO
• 分子量: 484.055
• InChiKey: MYCIHRZNJJAUBN-UHFFFAOYSA-N

物化性质

• 沸点：
  85 °C(Press: 0.998 Torr)
• 密度：
  1.705±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  26.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.1
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-Tetramethyl-1,8-diaminooctane 、 乙酰胺,2-溴-N-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)- 以 乙醚 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Enhanced activity of fluorinated quaternary ammonium surfactants against Pseudomonas aeruginosa

  摘要：

  A novel series of fluorinated quaternary bisammonium surfactants has been synthesized in view to optimize their antimicrobial activities against Pseudomonas aeruginosa. As compared with commercial references, most of the new surfactants synthesized exhibit an enhanced activity which is discussed as a function of the nature of the spacer group between the quaternized nitrogen atoms and of the nature of the connector function between the nitrogen atoms and the perfluorinated carbon chains. It appears that the fluorinated "Gemini" surfactants bearing an amide connector can be an interesting alternative to hydrocarbon ammonium salts as preservatives and disinfectants against R aeruginosa. (c) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.07.032
• 作为产物：
  描述：

  3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟-1-辛烷胺 、 溴乙酰溴 在 吡啶 作用下， 以 乙醚 为溶剂， 反应 12.0h， 以70%的产率得到乙酰胺,2-溴-N-(3,3,4,4,5,5,6,6,7,7,8,8,8-十三氟辛基)-
  参考文献：
  名称：

  Synthése de nouveaux intermédiaires F-alkyles précurseurs de tensioactifs cationiques hautement fluorés

  摘要：

  The syntheses of F-alkyl compounds such as(~)[GRAPHICS](~)(where R(F) = C4F9, C6F13, C8F17 and Q = S, O, NH) by the reaction of bromoacetyl bromide with an F-alkyl compound such as RFC2H4QH are reported. These compounds show high reactivity with nucelophilic substrates. They are intended for use as precursors of surfactants or as precursors of monomers for the elaboration of artificial vesicles.

  DOI：

  10.1016/s0022-1139(00)80210-9

文献信息

• Synthèse de nouveaux tensioactifs cationiques à partir des isothiocyanates de [2-(F-alkyl)éthyl] méthyléther et évaluation de leur pouvoir d'agrégation en vésicules
  作者：V. Krier、M.A. Jouani、A. Cambon

  DOI：10.1016/s0022-1139(98)00236-x

  日期：1998.11

  In this work we report the synthesis of [2-(F-alkyl)ethyl] methylether isothiocyanates by isomerisation of the corresponding thiocyanates. The isothiocyanates are very versatile potential synthetic intermediates. Their reactivity with diamines was investigated and the thioureas obtained, are excellent precursors in the synthesis of new perfluoroalkylated surfactants. The aggregation behaviour of some

  在这项工作中，我们报道了通过相应的硫氰酸酯的异构化合成[2-（F-烷基）乙基]甲基醚异硫氰酸酯。异硫氰酸酯是非常通用的潜在合成中间体。研究了它们与二胺的反应性，得到的硫脲是合成新的全氟烷基化表面活性剂的极好前体。研究了其中某些两亲物在水中的聚集行为。超声处理后，所测试的化合物形成囊泡系统，其通过冷冻断裂电子显微镜鉴定。
• Guittard, Frederic; Cambon, Aime, Bulletin de la Societe Chimique de France, 1995, vol. 132, p. 1133 - 1138
  作者：Guittard, Frederic、Cambon, Aime

  DOI：——

  日期：——
• Preparation and antimicrobial behaviour of gemini fluorosurfactants
  作者：Lionel Massi、Frédéric Guittard、Richard Levy、Yves Duccini、Serge Géribaldi

  DOI：10.1016/s0223-5234(03)00059-x

  日期：2003.5

  The introduction of perfluorinated chains in the molecular structure of quaternary ammonium gemini surfactants have led to particularly active antimicrobial agents evaluated in this work. Connectors and spacers were studied in relation with antimicrobial activity in order to determine which molecular parameters are 'critical' for biological activity. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
• Synthèse de 3-[2F-alkyléthylamino]-1,2-époxypropanes et obtention de nouveaux tensioactifs mono ou bicaténaires à tête β-hydroxylée
  作者：P.S. Abenin、F. Szönyi、A. Cambon

  DOI：10.1016/s0022-1139(00)81248-8

  日期：1991.11

  In this paper we report the synthesis of new intermediates of the type 3-[2-F-alkyl-ethylamino]-1,2-epoxypropanes which lead simply and with good yields to a large range of fluorinated monotailed, bitailed and hydrogenated/fluorinated bitailed surfactants having a secondary amino group and at least one hydroxy group. Evaluation of their surface properties has allowed the contribution of each hydrophobic tail contained in the hydrogenated and fluorinated bitailed molecules to be demonstrated.
• ALAIN, SISMONDI;ABENIN, PARFAIT;CAMBON, AIME
  作者：ALAIN, SISMONDI、ABENIN, PARFAIT、CAMBON, AIME

  DOI：——

  日期：——