(2,2-dimethyl-1,3-dioxolan-4-yl)methyl formate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,2-dimethyl-1,3-dioxolan-4-yl)methyl formate
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: IEVYEDJKNBCNOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  formyloxyacetoxyphenylmethane 、 丙酮缩甘油 在 碳酸氢钠 作用下， 以 neat (no solvent) 为溶剂， 反应 16.0h， 以87%的产率得到(2,2-dimethyl-1,3-dioxolan-4-yl)methyl formate
  参考文献：
  名称：

  甲酰氧基乙酰氧基苯甲烷和1,1-二醛作为醇类通用的O-甲酰化和O-酰化试剂

  摘要：

  在无溶剂/催化剂的情况下，甲氧基乙氧基苯基甲烷，对称的1,1-二醛和混合的1-新戊氧基-1-酰氧基-1-苯基甲烷已被用作伯，仲醇，烯丙基醇和苯酚的湿气稳定的O-甲酰化和O-酰化试剂。条件以高收率得到其相应的酯。

  DOI：

  10.1016/j.tet.2018.09.014

文献信息

• METHOD OF PREPARING ESTER COMPOUND AND ESTER COMPOUND PREPARED THEREBY
  申请人：LG CHEM, LTD.

  公开号：US20150152036A1

  公开（公告）日：2015-06-04

  This invention relates to a method of preparing an ester compound, including adding carboxylic acid to a mixture of glycerol and acetone in the presence of a sulfuric acid catalyst and applying an ultrasonic wave to induce an esterification reaction, and to an ester compound prepared thereby.

  这项发明涉及一种制备酯化合物的方法，包括在硫酸催化剂的存在下，将羧酸加入甘油和丙酮的混合物中，并施加超声波以诱导酯化反应，以及由此制备的酯化合物。
• Selective Esterifications of Primary Alcohols in a Water-Containing Solvent
  作者：Yong Wang、Bilal A. Aleiwi、Qinghui Wang、Michio Kurosu

  DOI：10.1021/ol3022337

  日期：2012.9.21

  Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO3, and Oxyma or Oxyma derivative 5b in 5% H2O-CH3CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.
• Enhanced enantioselectivity of Bacillus coagulans in the hydrolysis of 1,2-O-isopropylidene glycerol esters by thermal knock-out of undesired enzymes
  作者：Diego Romano、Francesco Falcioni、Diego Mora、Francesco Molinari、Andreas Buthe、Marion Ansorge-Schumacher

  DOI：10.1016/j.tetasy.2004.12.021

  日期：2005.2

  The enantioselective hydrolysis of different (RS)-1,2-O-isopropylidene glycerol esters has been achieved with whole cells of Bacillus coagulans NCIMB 9365 furnishing the (S)-alcohol as the major enantiomer. The reaction is catalysed by a thermostable cell-bound carboxylesterase and improvement of the enantioselectivity has been achieved by heat treatment of the whole cells, which causes the knock-outs a non-enantioselective competing enzyme. Thermally-treated cells hydrolysed (RS)-1,2-O-isopropylidene glycerol esters with high enantioselectivity, the highest enantiomeric ratio (80-100) being observed for the benzoate. The biocatalyst displayed good stability and could be re-used after filtration for 12 cycles before showing significant loss of activity; repeated biotransformation batches allowed the recovery of 9.55 g/L of enantiomerically pure (S)-isopropylideneglycerol benzoate starting from 24.0 g/L of the racemic mixture. (C) 2005 Elsevier Ltd. All rights reserved.
• Didehydromilbemycin derivatives, their preparation and compositions containing them
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0110667B1

  公开（公告）日：1987-01-28
• COPOLYMERES THERMOASSOCIATIFS ET ECHANGEABLES, COMPOSITION LES COMPRENANT
  申请人：Total Marketing Services

  公开号：EP3762434B1

  公开（公告）日：2022-05-04