4-n-Propylaminochinaldin | 30980-55-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-n-Propylaminochinaldin
• 英文别名: 2-methyl-N-propylquinolin-4-amine
• CAS: 30980-55-3
• 化学式: C₁₃H₁₆N₂
• 分子量: 200.283
• InChiKey: DTMDQZTWFWKWNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,6-二碘己烷 、 4-n-Propylaminochinaldin 在 丁酮 作用下， 生成 2,2'-dimethyl-4,4'-bis-propylamino-1,1'-hexanediyl-bis-quinolinium; diiodide
  参考文献：
  名称：

  Austin et al., Journal of Pharmacy and Pharmacology, 1959, vol. 11, p. 80,86

  摘要：

  DOI：
• 作为产物：
  描述：

  正丙胺 、 4-氯喹哪啶 生成 4-n-Propylaminochinaldin
  参考文献：
  名称：

  Fulton et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1950, vol. 137, p. 339,350

  摘要：

  DOI：

文献信息

• Microwave-Assisted Efficient Synthesis of 4-Substituted Amino-2-methylquinolines Catalyzed by p-Toluenesulfonic Acid
  作者：Xiao-qin Wang、Wen-jia Pan、Yuan-hong Cai、Xiao-yang Xie、Cui-ying Huang、Jia-yu Li、Wen-na Chen、Ming-hua He

  DOI：10.3987/com-16-13516

  日期：——

  A series of novel 4-subtituted amino-2-methylquinolines (3a-3o) were readily synthesized via the reaction of 4-chloro-2-methylquinoline with amines catalyzed by p-toluenesulfonic acid (TsoH) at 120 degrees C for 1 h under microwave-assisted organic synthesis (MAOS) condition. The yields of products 3a-3o were in range of 55-89%. This approach has advantages such as higher yield, shorter reaction time, lower costs, more convenience, and higher efficiency compared to the conventional method. The structures of the products were characterized by using H-1 NMR, C-13 NMR and HRMS. The reactivity of different amines was discussed.
• PEDERSEN, E. B.;CARLSEN, D., CHEM. SCR., 1981, 18, N 5, 240-241
  作者：PEDERSEN, E. B.、CARLSEN, D.

  DOI：——

  日期：——
• Austin et al., Journal of Pharmacy and Pharmacology, 1959, vol. 11, p. 80,86
  作者：Austin et al.

  DOI：——

  日期：——
• Fulton et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1950, vol. 137, p. 339,350
  作者：Fulton et al.

  DOI：——

  日期：——