2-acetylthiophene dimethoxy acetal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-acetylthiophene dimethoxy acetal
• 英文别名: 2-(1,1-Dimethoxyethyl)thiophene
• 化学式: C₈H₁₂O₂S
• 分子量: 172.248
• InChiKey: LNNWJTUVSCKREY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-acetylthiophene dimethoxy acetal 在 吡啶 作用下， 以 甲醇 为溶剂， 反应 28.0h， 生成 2-acetylamino-5-trifluoromethyl-7-(2-thienyl)-1,8-naphthyridine
  参考文献：
  名称：

  方便的一锅法合成含三氟甲基的 2-氨基-7-烷基（芳基/杂芳基）-1,8-萘啶和稠合环烷类似物的通用途径

  摘要：

  从 4-烷氧基-的直接环缩合反应合成新系列 7-烷基（芳基/杂芳基）-2-氨基-5-三氟甲基-1,8-萘啶的简便通用方法，产率为 26-73% 1,1,1-trifluoroalk-3-en-2-ones [CF3C(O)CH=C(R1)OR, 其中 R1 = H, Me, Ph, 4-MePh, 4-OMePh, 4-FPh, 4描述了 -BrPh、4-NO2Ph、2-呋喃基、2-噻吩基和 R = Me, Et] 与 2,6-二氨基吡啶 (2,6-DAP) 在温和条件下的反应。另一种合成路线还允许从五、六和七的直接或间接环缩合反应合成 2-氨基-5-三氟甲基-环烷[b][1,8]萘啶，产率为 33-36%。 2-三氟乙酰基-1-甲氧基-环烯烃与 2,6-DAP。

  DOI：

  10.3390/molecules16042817
• 作为产物：
  描述：

  2-乙酰基噻吩 、 原甲酸三甲酯 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 生成 2-acetylthiophene dimethoxy acetal
  参考文献：
  名称：

  Eco-friendly synthesis and antioxidant activity of new trifluoromethyl-substituted N -(pyrimidin-2-yl)benzo[ d ]thiazol-2-amines and some N-derivatives

  摘要：

  AbstractA convenient and environmentally benign procedure for the synthesis of a new series of trifluoromethyl-substituted N-(pyrimidin-2-yl)benzo[d]thiazol-2-amines by the cyclocondensation reaction of (benzo[d]thiazolyl)guanidine with either 4-alkoxy-4-alkyl(aryl/heteroaryl)-1,1,1-trifluoroalk-3-en-2-ones or 2,2,2-trifluoro-1-(2-methoxycyclohexen-1-en-1-yl)ethanone is described. The main reactions

  DOI：

  10.1007/s00706-016-1829-0

文献信息

• HClO₄ catalysed aldol-type reaction of fluorinated silyl enol ethers with acetals or ketals toward fluoroalkyl ethers
  作者：You-Ping Tian、Yi Gong、Xiao-Si Hu、Jin-Sheng Yu、Ying Zhou、Jian Zhou

  DOI：10.1039/c9ob02129a

  日期：——

  A highly efficient metal-free aldol-type reaction of various acetals or ketals with fluorinated silyl enol ethers catalysed by less than 1 mol% HClO4 (70 wt%, aq.) is developed. This provides expedient access to a wide array of valuable fluoroalkyl ethers featuring a ketone carbonyl functionality in good to excellent yields (40 examples). Furthermore, the thus obtained adducts are readily elaborated

  已开发出各种乙缩醛或缩酮与氟化甲硅烷基烯醇醚的高效无金属醛醇缩醛型反应，该氟化甲硅烷基烯醇醚由少于1 mol％的HClO4（水溶液中的70 wt％）催化。这可以方便地获得各种有价值的具有酮羰基官能度的有价值的氟代烷基醚，产率高至优异（40个实例）。此外，将如此获得的加合物容易地精加工成其他具有丰富结构的含氟烷基醚。
• Eco-friendly synthesis and antioxidant activity of new trifluoromethyl-substituted N-(pyrimidin-2-yl)benzo[d]thiazol-2-amines and some N-derivatives
  作者：Helio G. Bonacorso、Tainara P. Calheiro、Melissa B. Rodrigues、Sílvio T. Stefanello、Félix A. A. Soares、Nilo Zanatta、Marcos A. P. Martins

  DOI：10.1007/s00706-016-1829-0

  日期：2016.12

  reactions were performed in refluxing water as the solvent (8–24 h), without catalysts, and the corresponding new N-(pyrimidinyl)-1H-(benzo[d]thiazolyl)amines were obtained at a 60–88 % yield. Subsequently, some di(hetero)arylamines were derivatized to the respective tertiary amines via easy N-alkylation and N-alkenylation reactions at 55–82 % yields. Finally, the Lipinski parameters and the total antioxidant

  AbstractA convenient and environmentally benign procedure for the synthesis of a new series of trifluoromethyl-substituted N-(pyrimidin-2-yl)benzo[d]thiazol-2-amines by the cyclocondensation reaction of (benzo[d]thiazolyl)guanidine with either 4-alkoxy-4-alkyl(aryl/heteroaryl)-1,1,1-trifluoroalk-3-en-2-ones or 2,2,2-trifluoro-1-(2-methoxycyclohexen-1-en-1-yl)ethanone is described. The main reactions
• Cyclopentene Assembly by Microwave-Assisted Domino Reaction of Donor–Acceptor Cyclopropanes with Ketals
  作者：Hung M. Nguyen、Hemender R. Chand、Nikita E. Golantsov、Igor V. Trushkov、Leonid G. Voskressensky

  DOI：10.1055/s-0039-1690775

  日期：2020.2

  A Lewis acid-mediated domino reaction of acetals derived from aromatic ketones with 2-(het)arylcyclopropane-1,1-diesters has been developed. The reaction provides a convenient approach to cyclopentenes and related polycyclic ring systems.

  已开发出由芳香酮衍生的缩醛与 2-（杂）芳基环丙烷-1,1-二酯的路易斯酸介导的多米诺反应。该反应为环戊烯和相关多环系统提供了一种方便的方法。
• [EN] CONTROLLED-RELEASE SEDATIVE-HYPNOTIC COMPOSITIONS AND METHODS RELATED THERETO<br/>[FR] COMPOSITIONS HYPNOTIQUES SEDATIVES A LIBERATION CONTROLLEE ET PROCEDES CORRESPONDANTS
  申请人：NEUROCRINE BIOSCIENCES INC

  公开号：WO2001013895A2

  公开（公告）日：2001-03-01

  Controlled-release formulations providing a 'pulsed' plasma profile of a sedative-hypnotic compounds having a particularly short half-life are provided. The formulation contains a sedative-hypnotic compound or precursor thereof that is metabolized to generate a sedative-hypnotic compound in vivo, wherein the compound has a mean plasma half life ranging from 0.1 to 2 hours; and at least one release retardant such that, following administration of the formulation to a patient, the patient has specified pulsed plasma profile for the sedative-hypnotic compound as disclosed herein. In a preferred embodiment, the sedative-hypnotic compound is NBI-34060.

  本发明提供了一种控制释放配方，可提供具有特别短半衰期的催眠镇静化合物的“脉冲”血浆剖面。该配方包含一种催眠镇静化合物或其前体，该化合物在体内代谢产生催眠镇静化合物，其中该化合物的平均血浆半衰期范围为0.1至2小时；以及至少一种释放延缓剂，使得在向患者给予该配方后，患者具有如本文所述的特定脉冲血浆剖面的催眠镇静化合物。在一种优选实施例中，催眠镇静化合物为NBI-34060。
• Electrophilic Additions to η²-Thiophene Complexes:  Synthesis of Novel Thiophenium and Thiafulvenium Species
  作者：Michael L. Spera、W. D. Harman

  DOI：10.1021/om990199s

  日期：1999.8.1

  A series of complexes of the form [Os(NH3)(5)(eta(2)-L)](OTf)(2) (where L = thiophene and OTf = trifluoromethanesulfonate, i.e., triflate) are synthesized and characterized and their reactivities with electrophilic reagents are examined. Depending on the electrophile and the substitution pattern of the coordinated thiophene, direct electrophilic addition occurs at either the sulfur, C2, or C3, affording thiophenium complexes. Some elementary transformations of selected thiophene complexes are exploited to prepare novel 1- and 2-thiafulvenium salts.