3-hydroxy-2,4,6-triiodobenzaldehyde | 224641-82-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-hydroxy-2,4,6-triiodobenzaldehyde
• 英文别名: 2,4,6-triiodo-3-hydroxybenzaldehyde；3-hydroxy-2,4,6-triiodo-benzaldehyde；3-Hydroxy-2,4,6-trijod-benzaldehyd
• CAS: 224641-82-1
• 化学式: C₇H₃I₃O₂
• 分子量: 499.813
• InChiKey: PYEXBDXARWXOHC-UHFFFAOYSA-N

物化性质

• 熔点：
  146 °C
• 沸点：
  362.4±42.0 °C(Predicted)
• 密度：
  3.015±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-hydroxy-2,4,6-triiodobenzaldehyde 在 N-甲基吗啉 作用下， 反应 6.0h， 以92%的产率得到3-羟基-4-碘苯甲醛
  参考文献：
  名称：

  Nonreductive Deiodination of ortho-Iodo-Hydroxylated Arenes Using Tertiary Amines

  摘要：

  [GRAPHIC]A convenient and nonreductive deiodination is reported for the ortho-iodo-hydroxylated arenes inch, ding derivatives of quinolinol, phenol, and naphthol. Tertiary amines pyridine, triethylamine, and N-methylmorpholine in the presence of water initiated deiodination of ortho-iodo-hydroxylated arenes without affecting para-iodine and other reduction-susceptible groups. This reported method also works efficiently for polyiodinated systems. Simplicity, short reaction times, and absence of reducing catalyst are features of this method.

  DOI：

  10.1021/jo051191x
• 作为产物：
  描述：

  间羟基苯甲醛 在 碘 、 sodium carbonate 、 sodium iodide 作用下， 以 水 为溶剂， 以90.3 %的产率得到3-hydroxy-2,4,6-triiodobenzaldehyde
  参考文献：
  名称：

  RADIOPAQUE POLYMERS

  摘要：

  The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from —OH, —COOH, —SO 3 H, —OPO 3 H 2 , —O—(C 1-4 alkyl), —O—(C 1-4 alkyl)OH, —O—(C 1-4 alkyl)R 2 , —O—(C 2 H 5 O) q R 1 —(C═O)—O— C 1-4 alkyl and —O—(C═O)C 1-4 alkyl; wherein R 1 is H or C 1-4 alkyl; R 2 is —COOH, —SO 3 H, or —OPO 3 H 2 ; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.

  公开号：

  US20230355833A1

文献信息

• 17. The iodination of 3-hydroxy- and of nitrated 3-hydroxybenzaldehydes, and the nitration of certain iodo-3-hydroxybenzaldehydes
  作者：Herbert H. Hodgson、Ernest W. Smith

  DOI：10.1039/jr9370000076

  日期：——
• X-Ray Diagnostics. IV. Cholecystographic Agents
  作者：Domenick Papa、Hilda Breiger、Erwin Schwenk、Virginia Peterson

  DOI：10.1021/ja01167a015

  日期：1950.11
• C-methylation of phenols, tyrosine derivatives, and a tyrosine containing peptide
  作者：Tony L. Hudgens、Kenneth D. Turnbull

  DOI：10.1016/s0040-4039(99)00348-2

  日期：1999.4

  A two step procedure is reported for the efficient C-methylation of phenolic compounds using a Stille reaction. This procedure requires no phenol protection and is tolerant to a wide variety of functional groups. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Pandya et al., Journal of the Indian Chemical Society, 1952, vol. 29, p. 363,364
  作者：Pandya et al.

  DOI：——

  日期：——
• Alpha-substituted, hydroxy halogen-substituted cinnamic acids and nontoxic salts
  申请人：SCHERING INTERNAT RES INST

  公开号：US02671802A1

  公开（公告）日：1954-03-09