ethyl 3-(benzyloxy)-5-hydroxybenzoate | 497069-12-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 3-(benzyloxy)-5-hydroxybenzoate
• 英文别名: Benzoic acid, 3-hydroxy-5-(phenylmethoxy)-, ethyl ester；ethyl 3-hydroxy-5-phenylmethoxybenzoate
• CAS: 497069-12-2
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: QZAMCSNTILSOSP-UHFFFAOYSA-N

物化性质

• 沸点：
  446.5±30.0 °C(Predicted)
• 密度：
  1.199±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 3-(benzyloxy)-5-hydroxybenzoate 在 lithium aluminium tetrahydride 、 18-冠醚-6 、 potassium carbonate 、 pyridinium chlorochromate 、 sodium iodide 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 反应 51.0h， 生成 (3-Benzyloxy-5-formyl-phenoxy)-acetic acid tert-butyl ester
  参考文献：
  名称：

  Invertible Amphiphilic Homopolymers

  摘要：

  Stimuli-responsive polymers and assemblies are viable candidates for the so-called "smart" materials. In this communication, we report a new class of amphiphilic homopolymers that forms micelle-like structures in polar solvents and inverted micelle-like structures in apolar solvents. We demonstrate that these superstructures are the result of the changes in the molecular-level conformations in the monomer.

  DOI：

  10.1021/ja047816a
• 作为产物：
  描述：

  3,5-二羟基苯甲酸 在 18-冠醚-6 、 硫酸 、 乙酸酐 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 8.0h， 生成 ethyl 3-(benzyloxy)-5-hydroxybenzoate
  参考文献：
  名称：

  Invertible Amphiphilic Homopolymers

  摘要：

  Stimuli-responsive polymers and assemblies are viable candidates for the so-called "smart" materials. In this communication, we report a new class of amphiphilic homopolymers that forms micelle-like structures in polar solvents and inverted micelle-like structures in apolar solvents. We demonstrate that these superstructures are the result of the changes in the molecular-level conformations in the monomer.

  DOI：

  10.1021/ja047816a

文献信息

• Synthesis of Organometallic Poly(dendrimer)s by Macromonomer Polymerization: Effect of Dendrimer Size and Structural Rigidity on the Polymerization Efficiency
  作者：Siu-Yin Cheung、Hak-Fun Chow、To Ngai、Xiaoling Wei

  DOI：10.1002/chem.200802306

  日期：2009.2.23

  propagation: The copolymerization behavior of a dendritic macromonomer with a metal‐containing linker is controlled by the dendrimer size and its structural rigidity. Structurally more flexible dendritic monomers tend to form more cyclic oligomers than structurally rigid monomers (see figure).

  环化与扩散：树枝状大分子与含金属连接基的共聚行为受树枝状大分子的大小及其结构刚性的控制。结构上较柔性的树枝状单体比结构上刚性的单体倾向于形成更多的环状低聚物（见图）。
• BENZOATE COMPOUND
  申请人：SCOHIA PHARMA, INC.

  公开号：US20210403420A1

  公开（公告）日：2021-12-30

  The present invention provides a benzoic acid ester compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. A compound represented by the formula (I) or a salt thereof has an enteropeptidase inhibitory effect and is useful as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like: [in the formula, each symbol is as defined in the specification].

  本发明提供了一种苯甲酸酯化合物，具有肠肽酶抑制作用，并将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物。由式（I）表示的化合物或其盐具有肠肽酶抑制作用，并可用作治疗或预防肥胖、糖尿病等疾病的药物。【在公式中，每个符号如规范中定义】。
• Invertible amphiphilic polymers
  申请人：Thayumanavan Sankaran

  公开号：US20070293669A1

  公开（公告）日：2007-12-20

  Amphiphilic monomeric compounds and corresponding homopolymers and copolymers capable of assembly and invertible configuration in introduction to and change in fluid medium.

  具有两性单体化合物及相应的同聚物和共聚物能够在流体介质中进行组装和可逆配置。
• FUSED HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20180072694A1

  公开（公告）日：2018-03-15

  The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. Specifically, the present invention relates to a compound represented by the formula (I) or a salt thereof, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like [in the formula, each symbol is as defined in the specification].

  本发明涉及一种具有肠肽酶抑制作用的缩合杂环化合物，以及将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物。具体而言，本发明涉及由式(I)表示的化合物或其盐，以及将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物【在公式中，每个符号均如规范中定义】。
• A Mild Deprotection Strategy for Allyl-Protecting Groups and Its Implications in Sequence Specific Dendrimer Synthesis
  作者：Dharma Rao Vutukuri、Pandi Bharathi、Zhouying Yu、Karthik Rajasekaran、My-Huyen Tran、S. Thayumanavan

  DOI：10.1021/jo026469p

  日期：2003.2.1

  A mild deprotection strategy for allyl ethers under basic conditions in the presence of a palladium catalyst is described. Under these conditions, aryl allyl ethers can be cleaved selectively in the presence of alkyl allyl ethers. These conditions are also effective in the deprotection of allyloxycarbonyl groups. The utility of the current methodology in sequence specific dendrimer synthesis is demonstrated

  描述了在碱性条件下在钯催化剂存在下对烯丙基醚的温和脱保护策略。在这些条件下，可以在烷基烯丙基醚的存在下选择性地裂解芳基烯丙基醚。这些条件对于烯丙氧羰基的脱保护也是有效的。证明了当前方法在序列特异性树状聚合物合成中的实用性。