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1-(4-methylbenzyloxy)-2-methylbenzene | 500149-86-0

中文名称
——
中文别名
——
英文名称
1-(4-methylbenzyloxy)-2-methylbenzene
英文别名
1-Methyl-4-(2-methylphenoxymethyl)benzene;1-methyl-2-[(4-methylphenyl)methoxy]benzene
1-(4-methylbenzyloxy)-2-methylbenzene化学式
CAS
500149-86-0
化学式
C15H16O
mdl
MFCD20042411
分子量
212.291
InChiKey
RYXUFINAMSYWQJ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    319.6±11.0 °C(Predicted)
  • 密度:
    1.027±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    4.2
  • 重原子数:
    16
  • 可旋转键数:
    3
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.2
  • 拓扑面积:
    9.2
  • 氢给体数:
    0
  • 氢受体数:
    1

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    1-(4-methylbenzyloxy)-2-methylbenzene磺酰氯caesium carbonate 、 sodium iodide 、 Merrifield resin 作用下, 以 二氯甲烷N,N-二甲基甲酰胺 为溶剂, 反应 52.42h, 生成 4-氯-2-甲基苯酚
    参考文献:
    名称:
    On the para-selective chlorination of ortho-cresol
    摘要:
    Merrifield-bound o-cresol undergoes electrophilic aromatic chlorination using SO2Cl2 leading to para/ortho ratios in excess of 50, the highest such ratio reported for this chlorinating agent. Model studies suggest that this significant para/ortho ratio results not just from steric effects but that considerable electronic influence can be detected. (C) 2002 Elsevier Science Ltd. All rights reserved.
    DOI:
    10.1016/s0040-4020(02)00996-1
  • 作为产物:
    描述:
    2-甲基-1-苄氧基苯磺酰氯potassium carbonate 作用下, 以 二氯甲烷丙酮 为溶剂, 反应 0.42h, 生成 1-(4-methylbenzyloxy)-2-methylbenzene
    参考文献:
    名称:
    On the para-selective chlorination of ortho-cresol
    摘要:
    Merrifield-bound o-cresol undergoes electrophilic aromatic chlorination using SO2Cl2 leading to para/ortho ratios in excess of 50, the highest such ratio reported for this chlorinating agent. Model studies suggest that this significant para/ortho ratio results not just from steric effects but that considerable electronic influence can be detected. (C) 2002 Elsevier Science Ltd. All rights reserved.
    DOI:
    10.1016/s0040-4020(02)00996-1
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文献信息

  • MCM-41-immobilized 1,10-phenanthroline–copper(<scp>i</scp>) complex: a highly efficient and recyclable catalyst for the coupling of aryl iodides with aliphatic alcohols
    作者:Yang Lin、Mingzhong Cai、Zhiqiang Fang、Hong Zhao
    DOI:10.1039/c6ra19825b
    日期:——
    A heterogeneous C–O coupling reaction between aryl iodides and aliphatic alcohols was achieved in neat alcohol or toluene at 110 °C in the presence of 10 mol% of the MCM-41-immobilized 1,10-phenanthroline–copper(I) complex [MCM-41-1,10-phen–CuI] with Cs2CO3 as a base, yielding a variety of aryl alkyl ethers in good to excellent yields. The new heterogeneous copper catalyst can easily be prepared by
    在存在10 mol%的MCM-41固定的1,10-咯啉-(I)络合物的存在下,在110°C的纯醇或甲苯中,芳基化物和脂肪醇之间的异质C-O偶联反应得以实现[以Cs 2 CO 3为碱的MCM-41-1,10-phen-CuI] ,可产生各种芳基烷基醚,收率好至极佳。新的多相催化剂可以很容易地通过简单的方法由市售和廉价的试剂制备,并通过过滤反应溶液进行回收并循环至少8次而不会显着降低活性。
  • AZOLYLMETHYLIDENEHYDRAZINE DERIVATIVE AND USE THEREOF
    申请人:Ogura Hironobu
    公开号:US20100190754A1
    公开(公告)日:2010-07-29
    An azolylmethylidenehydrazine derivative represented by the formula (I) wherein Ar is an aryl group optionally having substituent(s) or a heteroaryl group optionally having substituent(s), R 1 and R 2 are the same or different and each is an alkyl group, a cycloalkyl group, an aralkyl group optionally having substituent(s), an aryl group optionally having substituent(s), a heteroarylalkyl group optionally having substituent(s), or R 1 and R 2 are bonded to each other to form a nitrogen-containing heterocyclic group optionally having substituent(s), and X is CH or a nitrogen atom, or a pharmacologically acceptable salt thereof is useful as a medicament, particularly as an antifungal agent, or an anti-inflammatory agent or an antiallergic agent.
    一种以式(I)表示的氮杂环甲基亚唑啉衍生物,其中Ar是一个芳基基团,可选择地具有取代基,或者是一个杂芳基基团,可选择地具有取代基;R1和R2相同或不同,每个都是一个烷基基团、环烷基基团、可选择地具有取代基的芳基烷基基团、可选择地具有取代基的芳基基团、可选择地具有取代基的杂芳基烷基基团,或者R1和R2彼此连接形成一个可选择地具有取代基的含氮杂环基团;X是CH或氮原子;或其药学上可接受的盐,可用作药物,特别是作为抗真菌药物、抗炎药物或抗过敏药物。
  • BICYCLIC HETEROCYCLIC DERIVATIVE
    申请人:Nakahira Hiroyuki
    公开号:US20110190278A1
    公开(公告)日:2011-08-04
    The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R 1a is halogen, etc.; R 1m is H, etc.; G 1 is —N(R 1b )—, etc.; G 2 is —CO—, etc.; G 3 is —C(R 1c )(R 1d )—, etc.; G 4 is oxygen, etc.; R 1b is optionally substituted C 1-6 alkyl, etc.; R 1c and R 1d are independently the same or different, H, etc.; R 3 is H, optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3 c and R 3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]
    本发明涉及以下式(I)的化合物或其药学上可接受的盐,其可用作肾素抑制剂。[其中,R1a是卤素等;R1m是H等;G1是—N(R1b)—等;G2是—CO—等;G3是—C(R1c)(R1d)—等;G4是氧等;R1b是可选取代的C1-6烷基等;R1c和R1d独立选择为H等;R3是H、可选取代的C1-6烷基等;R3a、R3b、R3c和R3d独立选择为相同或不同的基团:-A-B(其中A是单键等,B是H等)等;n为1等。]
  • N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE
    申请人:Suetsugu Satoshi
    公开号:US20120122773A1
    公开(公告)日:2012-05-17
    The present invention provides a compound of formula (I): wherein R 1a is optionally substituted C 1-6 alkyl, etc.; R 1m is hydrogen atom, etc.; G 1 , G 2 , G 3 and G 4 are (i), etc. ((i) G 1 is —N(R 1b )—, G 2 is —CO—, G 3 is —C(R 1c )(R 1d )—, and G 4 is oxygen, etc.); R 1b is optionally substituted C 1-6 alkyl, etc.; R 1c and R 1d are each independently optionally substituted C 1-6 alkyl, etc.; R 2 is optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3c and R 3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R 5 is C 1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.
    本发明提供了一种化合物,其化学式为(I):其中R1a是可选取代的C1-6烷基等;R1m是氢原子等;G1,G2,G3和G4是(i)等,((i) G1是—N(R1b)—,G2是—CO—,G3是—C(R1c)(R1d)—,G4是氧原子等);R1b是可选取代的C1-6烷基等;R1c和R1d分别独立地是可选取代的C1-6烷基等;R2是可选取代的C1-6烷基等;R3a、R3b、R3c和R3d分别独立地是一种基团:-A-B(其中A是单键等,B是氢原子等)等;n是1等;R5是C1-4烷氧羰基等,或其药学上可接受的盐,其作为一种肾素抑制剂是有用的。
  • AZOLYLMETHYLENEHYDRAZINE DERIVATIVE AND USE THEREOF
    申请人:KAKEN PHARMACEUTICAL CO., LTD.
    公开号:EP2168951A1
    公开(公告)日:2010-03-31
    An azolylmethylidenehydrazine derivative represented by the formula (I) wherein Ar is an aryl group optionally having substituent(s), a heteroaryl group optionally having substituent(s) or a heteroaryl group optionally having substituent(s), R1 and R2 are the same or different and each is an alkyl group, a cycloalkyl group, an aralkyl group optionally having substituent(s), an aryl group optionally having substituent(s), a heteroarylalkyl group optionally having substituent(s), or R1 and R2 are bonded to each other to form a nitrogen-containing heterocyclic group optionally having substituent(s), and X is CH or a nitrogen atom, or a pharmacologically acceptable salt thereof is useful as a medicament, particularly as an antifungal agent, or an anti-inflammatory agent or an antiallergic agent.
    由式 (I) 代表的偶氮亚甲基生物 其中 Ar 是可选具有取代基的芳基、可选具有取代基的杂芳基或可选具有取代基的杂芳基、 R1 和 R2 相同或不同,且各自为烷基、环烷基、任选具有取代基的芳烷基、任选具有取代基的芳基、任选具有取代基的杂芳基,或 R1 和 R2 相互键合形成任选具有取代基的含氮杂环基,且 X 为 CH 或氮原子、 或其药理上可接受的盐可用作药物,特别是抗真菌剂、抗炎剂或抗过敏剂。
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