N,N-diallylquinolin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N,N-diallylquinolin-2-amine
• 英文别名: Diallylaminoquinoline；N,N-bis(prop-2-enyl)quinolin-2-amine
• 化学式: C₁₅H₁₆N₂
• 分子量: 224.305
• InChiKey: KOLIDVXYAOCKAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-diallylquinolin-2-amine 在 palladium on activated charcoal 甲烷磺酸 作用下， 以 乙醇 为溶剂， 生成 2-(β-hydroxypropyl)aminoquinoline
  参考文献：
  名称：

  Allyl amines as ammonia equivalents in the preparation of anilines and heteroarylamines

  摘要：

  A series of anilines and heteroarylamines were synthesized in moderate to excellent yields by palladium catalyzed cross coupling reaction of aryl or heteroaryl halides with allyl-or N,N-diallylamine followed by deallylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10877-2
• 作为产物：
  描述：

  2-喹啉醇 在 4-二甲氨基吡啶 、 lithium chloro-isopropyl-magnesium chloride 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 56.0h， 生成 N,N-diallylquinolin-2-amine
  参考文献：
  名称：

  酰胺化氨基磷酸二氨基磷酸酯取代的吡啶和相关的N-杂环

  摘要：

  各种二氨基磷酸酯基取代的吡啶，喹啉，并用镁酰胺喹喔啉的胺化- [R 2个8小时内于室温下NMgCl·LiCl前进。几种药物活性胺是用于该胺化程序的合适底物，并且还制备了抗组胺的三烯胺。另外，使用TMPMgCl·LiCl（TMP = 2,2,6,6-四甲基哌啶基）或TMP 2 Mg·2LiCl对几种杂环二氨基氨基磷酸酯进行定向邻位金属化（D o M），然后在胺化步骤之前进行亲电子官能化，导致邻官能化的胺化N-杂环。

  DOI：

  10.1021/acs.orglett.8b03698

文献信息

• Copper-Catalyzed Deoxygenative C-2 Amination of Quinoline <i>N</i> -Oxides
  作者：Zhihui Wang、Man-Yi Han、Pinhua Li、Lei Wang

  DOI：10.1002/ejoc.201800963

  日期：2018.11.25

  An unprecedented reaction between quinoline N‐oxides with O‐benzoylhydroxylamines was developed by using CuCl as catalyst, generating deoxygenative products of 2‐aminoquinolines in good yields. 1,2‐Dichloroethane (DCE) as solvent also served as reducing agent to cleave the N–O bond with no additional reductant needed in the reaction.

  通过使用CuCl作为催化剂，喹啉N-氧化物与O-苯甲酰基羟胺之间发生了前所未有的反应，从而以高收率产生了2-氨基喹啉的脱氧产物。1,2-二氯乙烷（DCE）作为溶剂也可以用作还原N-O键的还原剂，而反应中无需其他还原剂。
• Synthesis of Fluoroalkylated Pyrrolidines through Neat Reaction of Fluoroalkyl Iodides with <i>N, N</i> ‐Diallylamines
  作者：Ting Mao、Weipiao Li、Xiao‐Xiao Liu、Haoyang Wang、Wen‐Yong Han、Jie Tong、Shi‐Ji Xiao、Liang Zhao、Chun‐Yang He

  DOI：10.1002/adsc.202300092

  日期：——

  We presented a cascade transformation of N, N-diallylamines and fluoroalkyl iodides into various functionalized fluoroalkylated pyrrolidines through a visible light-induced synthetic process in the solvent-free conditions. In this reaction system, the substrate N, N-diallylamine acted both as the base and the electron donor. We further demonstrated the practicality of this protocol by the direct modification

  我们提出了在无溶剂条件下通过可见光诱导合成过程将N , N-二烯丙基胺和氟烷基碘化物级联转化为各种功能化氟烷基化吡咯烷。在该反应体系中，底物N,N-二烯丙胺既充当碱基又充当电子供体。我们通过氨基酸和药物分子的直接修饰进一步证明了该方案的实用性。
• Quninoline Methanol Compounds for the Treatment and Prevention of Parasitic Infections
  申请人：Dow Geoffrey

  公开号：US20110092488A1

  公开（公告）日：2011-04-21

  Malaria is responsible for 1-2 million deaths and 300-500 million clinical cases annually and is an ever present problem for the military, tourists and business travelers. Mefloquine is known and used for malaria prophylaxis. However it is associated with neurological effects. The present invention is directed to providing new and novel quinoline analogs that are less neurotoxic than mefloquine without compromising efficacy. The present invention is also directed to the prevention and treatment of other microbial, parasitic, protozoan, bacterial and fungal diseases.
• ELECTROCONDUCTIVE COMPOSITION, ELECTRICAL CONDUCTOR, LAMINATE AND METHOD FOR PRODUCING SAME, ELECTROCONDUCTIVE FILM, AND SOLID ELECTROLYTE CONDENSER
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：US20160093413A1

  公开（公告）日：2016-03-31

  The electroconductive composition of the present invention contains an electroconductive polymer (A) having a sulfonic acid group and/or carboxylic acid group, and a basic compound (B) having two or more nitrogen atoms. The electrical conductor of the present invention consists of the electroconductive composition. In the laminate of the present invention, the electrical conductor is laminated on at least one surface of a substrate. The method for producing a laminate of the present invention includes applying the electroconductive composition to at least one surface of a substrate, heating and drying the composition, and forming an electrical conductor. The electroconductive film of the present invention is provided with the electrical conductor. The solid electrolyte condenser of the present invention is provided with a positive electrode consisting of a porous body of a valve metal, a dielectric layer formed by oxidizing the positive electrode surface, and one or more solid electrolyte layers formed on the dielectric layer surface side, and at least one of the solid electrolyte layers is formed of the electroconductive composition.
• US4420308A
  申请人：——

  公开号：US4420308A

  公开（公告）日：1983-12-13