6,7-dichloro-1,3,4,9-tetrahydro-benzo[b]thieno[3,4-e][1,4]diazepin-10-one | 70194-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 6,7-dichloro-1,3,4,9-tetrahydro-benzo[b]thieno[3,4-e][1,4]diazepin-10-one
• 英文别名: 6,7-dichloro-1,3,4,9-tetrahydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one；7,8-dichloro-1,3,5,10-tetrahydrothieno[3,4-c][1,5]benzodiazepin-4-one
• CAS: 70194-06-8
• 化学式: C₁₁H₈Cl₂N₂OS
• 分子量: 287.169
• InChiKey: SIVRBDFSCSMNGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,7-dichloro-1,3,4,9-tetrahydro-benzo[b]thieno[3,4-e][1,4]diazepin-10-one 在 N-氯代丁二酰亚胺 作用下， 生成 6,7-dichloro-4,9-dihydro-benzo[b]thieno[3,4-e][1,4]diazepin-10-one
  参考文献：
  名称：

  10-(Alkylamino)-4H-thieno[3,4-b][1,5]benzodiazepines. A novel class of potential neuroleptic agents

  摘要：

  An investigation of the structural requirements for CNS activity of the title compounds was undertaken. A synthesis of the precursor dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-ones was achieved and three routes for their conversion to the title compounds were developed. The compounds were tested for neuroleptic activity by means of the blockade or d-amphetamine lethality in aggregated mice and/or effects on locomotor activity in rats. Antidepressant activity was examined using inhibition of tetrabenazine-induced depression in mice. Most of the compounds were found to be potent neuroleptic agents with several exhibiting additional antidepressant activity.

  DOI：

  10.1021/jm00192a020
• 作为产物：
  描述：

  4,5-二氯邻苯二胺 、 4-氧四氢噻酚-3-羧酸甲酯 在 苯 、 溶剂黄146 、 three 、 甲苯 作用下， 以 苯 为溶剂， 反应 39.0h， 以giving 6,7-dichloro-1,3,4,9-tetrahydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one的产率得到6,7-dichloro-1,3,4,9-tetrahydro-benzo[b]thieno[3,4-e][1,4]diazepin-10-one
  参考文献：
  名称：

  Substituted thieno-benzodiazepines

  摘要：

  本披露描述了具有镇痛活性的取代的9,10-二氢-4H-噻吩[3,4-b][1,5]苯并二氮平。

  公开号：

  US04168269A1

文献信息

• US4168269A
  申请人：——

  公开号：US4168269A

  公开（公告）日：1979-09-18
• 10-(Alkylamino)-4H-thieno[3,4-b][1,5]benzodiazepines. A novel class of potential neuroleptic agents
  作者：Jeffrey B. Press、Corris M. Hofmann、Nancy H. Eudy、William J. Fanshawe、Ivana P. Day、Eugene N. Greenblatt、Sidney R. Safir

  DOI：10.1021/jm00192a020

  日期：1979.6

  An investigation of the structural requirements for CNS activity of the title compounds was undertaken. A synthesis of the precursor dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-ones was achieved and three routes for their conversion to the title compounds were developed. The compounds were tested for neuroleptic activity by means of the blockade or d-amphetamine lethality in aggregated mice and/or effects on locomotor activity in rats. Antidepressant activity was examined using inhibition of tetrabenazine-induced depression in mice. Most of the compounds were found to be potent neuroleptic agents with several exhibiting additional antidepressant activity.
• Substituted thieno-benzodiazepines
  申请人：American Cyanamid Company

  公开号：US04168269A1

  公开（公告）日：1979-09-18

  This disclosure describes substituted 9,10-dihydro-4H-thieno[3,4-b] [1,5]benzodiazepines which possess analgesic activity.

  本披露描述了具有镇痛活性的取代的9,10-二氢-4H-噻吩[3,4-b][1,5]苯二氮平。