1-ethoxyethyl 3-chloropropyl ether | 30502-41-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-ethoxyethyl 3-chloropropyl ether
• 英文别名: 1-Clor-3-(1'-aethoxyaetoxy)propan；1-chloro-3-(1-ethoxy-ethoxy)-propane；Acetaldehyd-ethyl-γ-chlorpropyl-acetal；Propane, 1-chloro-3-(1-ethoxyethoxy)-；1-chloro-3-(1-ethoxyethoxy)propane
• CAS: 30502-41-1
• 化学式: C₇H₁₅ClO₂
• mdl: MFCD19232972
• 分子量: 166.648
• InChiKey: BKFHNZUWBNFLFZ-UHFFFAOYSA-N

物化性质

• 沸点：
  180.9±15.0 °C(Predicted)
• 密度：
  0.988±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-ethoxyethyl 3-chloropropyl ether 在 copper(l) iodide 、 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 125.0h， 生成 (8R)-5,5-Trimethylendithio-1,(1'-aethoxyaethoxy)-decan-8-ol
  参考文献：
  名称：

  光学合成剂2-甲基和2-乙基-1，6-二氧杂螺[4.4]-壬基和-[4.5]癸-信息素geeminsamen chiralenVorläufer

  摘要：

  从一个常见的手性前体合成旋光的2-甲基-和2-乙基-1，6-二氧杂螺[4.4]壬烷和-[4.5]癸烷信息素

  DOI：

  10.1002/hlca.19800630724
• 作为产物：
  描述：

  三甲氧基酯 、 1-氯-1-乙氧基乙烷 生成 1-ethoxyethyl 3-chloropropyl ether
  参考文献：
  名称：

  Vilsmaier,E., Justus Liebigs Annalen der Chemie, 1970, vol. 742, p. 135 - 137

  摘要：

  DOI：

文献信息

• Synthesis of polyunsaturated constituents of phenolic lipids
  作者：John H.P Tyman、N Visani

  DOI：10.1016/s0009-3084(96)02654-0

  日期：1997.2

  The diene, (ZZ)-[(8,11)-pentadecadienyl]salicylic acid, (or 2-hydroxy-6-[(ZZ)-pentadeca-8,11-dienyl]benzoic acid), has been synthesised by two routes. In the first, the key intermediate methyl or ethyl 2-hydroxy-6-(7-bromoheptyl)benzoate has been converted to methyl or ethyl 2-hydroxy-6-(10-hydroxydec-8-ynyl)benzoate and thence by reaction of the corresponding bromide with 1-pentynylmagnesium bromide to methyl or ethyl 2-hydroxy-6-(pentadeca-8,11-dienyl)benzoate. Selective reduction afforded methyl or ethyl 2-hydroxy-6-[(ZZ)-pentadeca-8,11-dienyl]benzoate. An attempt to employ the Grignard reagent from methyl 2-methoxy-6-(non-8-ynyl)benzoate and reaction with 1-bromohex-2-yne was ineffective because of a side reaction of the former with ethylmagnesium bromide to give a ketone. In the third approach ethyl 2-methoxy-6-methylbenzoate was alkylated with 1-iodotetradeca-7,10-diyne and the product selectively reduced as before to the O-methyl ether ethyl ester. A variety of C-14 intermediates has been prepared for the derivation of the 8(E), 11(E), 8(E), 11(Z) and 8(2), 11(E) stereoisomers by the alkylation procedure. A similar methodology of alkylation can be adopted for obtaining corresponding trienes in which some progress has been made commencing with the synthesis of the 8(2),11(2),14 compound. (C) 1997 Elsevier Science Ireland Ltd.
• Synthese optisch aktiver 2-Methyl- und 2-Äthyl-1, 6-dioxaspiro [4.4]-nonan- und -[4.5]decan-Pheromone aus einem gemeinsamen chiralen Vorläufer
  作者：Ernst Hungerbühler、Reto Naef、Daniel Wasmuth、Dieter Seebach、Hans-Rudolf Loosli、Adolf Wehrli

  DOI：10.1002/hlca.19800630724

  日期：1980.10.29

  Synthesis of Optically Active 2-Methyl- and 2-Ethyl-1, 6-dioxaspiro [4.4]nonane- and -[4.5]decane Pheromones from a Common Chiral Precursor

  从一个常见的手性前体合成旋光的2-甲基-和2-乙基-1，6-二氧杂螺[4.4]壬烷和-[4.5]癸烷信息素
• Vilsmaier,E., Justus Liebigs Annalen der Chemie, 1970, vol. 742, p. 135 - 137
  作者：Vilsmaier,E.

  DOI：——

  日期：——