lepidine | 38755-69-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: lepidine
• 英文别名: 4-Methylen-1-methyl-1,4-dihydro-chinolin；Quinoline, 1,4-dihydro-1-methyl-4-methylene-；1-methyl-4-methylidenequinoline
• CAS: 38755-69-0
• 化学式: C₁₁H₁₁N
• 分子量: 157.215
• InChiKey: USLMIQZBFJQWQW-UHFFFAOYSA-N

物化性质

• 熔点：
  210 °C
• 沸点：
  257.1±23.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  lepidine 在 sodium hydroxide 作用下， 以 异丙醇 、 苯 为溶剂， 反应 15.17h， 生成 3,6-di(2-pyridyl)-1,4,1',4'-tetrahydro-1'-methylspiro(pyridazino-4,4'-quinoline)
  参考文献：
  名称：

  杂环阳离子的脱水碱基的环加成。2. s-四嗪与季le盐的脱水碱反应中的螺环和car体结构的合成

  摘要：

  DOI：

  10.1007/bf00471755
• 作为产物：
  描述：

  1,4-dimethylquinolinium iodide 在 sodium hydroxide 作用下， 以 苯 为溶剂， 反应 0.03h， 生成 lepidine
  参考文献：
  名称：

  杂环阳离子的脱水碱基的环加成。2. s-四嗪与季le盐的脱水碱反应中的螺环和car体结构的合成

  摘要：

  DOI：

  10.1007/bf00471755

文献信息

• Carbenoid reactions of trifluoromethylelement compounds. Part 4. Reactions of trifluoromethylzinc bromide with enamines and methylene bases
  作者：Wieland Tyrra、Dieter Naumann、Sergej V. Pasenok、Yurii L. Yagupolskii

  DOI：10.1016/0022-1139(94)03114-f

  日期：1995.2

  The reactions of ZnBr(CF3)·2CH3CN with 1-morpholinocyclo-pentene and -hexene have been investigated and found to yield mixtures of two isomers of 1-morpholino-1-cyanomethyl-2-difluoromethyl-cyclopentane and -hexane, respectively. The interaction with methylene bases of nitrogen heterocycles leads to the formation of trimethinecyanine dyes. This reaction sequence includes the formation of two carbon-carbon

  研究了ZnBr（CF 3）·2CH 3 CN与1-吗啉代环戊烯和-己烯的反应，并发现了1-吗啉代-1-氰基甲基-2-二氟甲基-环戊烷和-己烷的两种异构体的混合物，分别。与氮杂环的亚甲基碱基的相互作用导致形成三甲基花青染料。该反应顺序包括在一锅操作中形成两个碳-碳键。讨论了反应机理。
• SPECIFIC MONOCATIONIC MONOCHROMOPHORIC COMPOUNDS OF HYDRAZONE TYPE COMPRISING A 2-, 4-PYRIDINIUM OR 2-, 4-QUINOLINIUM UNIT, SYNTHESIS THEREOF, DYE COMPOSITIONS CONTAINING THEM, AND METHOD FOR DYEING KERATIN FIBRES
  申请人：David Herve

  公开号：US20090300856A1

  公开（公告）日：2009-12-10

  One subject of the present invention is monocationic monochromophoric compounds of formula (I) and/or (II) below: in which: R 1 represents a hydrogen or an alkyl, phenyl, benzyl, alkylcarbonyl, alkylsulphonyl, aminosulphonyl or aminocarbonyl radical; R 5 represents an alkyl, phenyl or benzyl radical; R 2 and R 3 , represent a halogen or an alkyl, aryloxy, arylamino, hydroxyl, alkoxy, (poly)hydroxyalkoxy, alkoxycarbonyl, alkylcarbonyloxy, amino, alkylcarbonylamino, aminocarbonyl, ureido, aminosulphonyl, alkylthio, alkylsulphonylamino, cyano, trifluoromethyl, thio, alkylsulphinyl or alkylsulphonyl radical; R 4 represents a hydrogen or an alkyl, amino, alkylcarbonylamino, ureido, alkylsulphonylamino, hydroxycarbonyl, alkoxycarbonyl, cyano, phenyl or benzyl radical; R 6 and R 7 , represent a hydrogen or an alkyl, alkylcarbonyl, alkoxycarbonyl, alkoxyaryl, aminoaryl, aminocarbonyl or alkylsulphonyl radical; and n is between 0 and 4, n′ is between 0 and 4, the electroneutrality of the compounds of formulae (I) and (II) being ensured by one or more cosmetically acceptable anions An. Another subject of the invention is dyeing compositions comprising said compounds as direct dye, and also a method for dyeing keratin fibres using this composition and a multicompartment device. It finally relates to methods for synthesizing compounds of formula (I) and/or (II).

  本发明的一个主题是式（I）和/或（II）的单阳离子单色基化合物： 其中： R1代表氢或烷基，苯基，苄基，烷基羰基，烷基磺酰基，氨基磺酰基或氨基羰基基团; R5代表烷基，苯基或苄基基团; R2和R3代表卤素或烷基，芳氧基，芳基氨基，羟基，烷氧基，（多）羟基烷氧基，烷氧羰基，烷基羰酸酯基，氨基，烷基羰基氨基，氨基羰基，脲基，氨基磺酰基，烷基硫醇，烷基磺酰氨基，氰基，三氟甲基，硫基，烷基亚磺酰基或烷基磺酰基基团; R4代表氢或烷基，氨基，烷基羰基氨基，脲基，烷基磺酰氨基，羟基羧基，烷氧羰基，氰基，苯基或苄基基团; R6和R7代表氢或烷基，烷基羰基，烷氧羰基，烷氧基芳基，氨基芳基，氨基羰基或烷基磺酰基基团; n在0到4之间，n'在0到4之间，式（I）和（II）化合物的电中性由一个或多个化妆品可接受的阴离子An保证。 本发明的另一个主题是包含上述化合物作为直接染料的染料组合物，以及使用该组合物染色角蛋白纤维的方法和多室装置。最后，本发明还涉及合成式（I）和/或（II）化合物的方法。
• INFRARED DYES FOR LASER MARKING
  申请人：AGFA-GEVAERT

  公开号：EP2722367B1

  公开（公告）日：2018-03-28
• Reactions of cyclic 1,3-dicarbonyl compounds with 1,2(1,4)-dihydro-1-methyl-2(4)-methylene-N-heterocycles. A new access to 6,12-methano-dibenz[d,g]-[1,3]oxazocinones
  作者：Hans-Georg Henning、Le Hoang Thanh、Jörg Laue、Barbara Urban、Günter Reck

  DOI：10.1007/bf00811679

  日期：1994.1

  The enamine-type methylene-N-heterocycles 1-5 react with cyclic 2-ethoxymethylene-1,3-dicarbonyl compounds 6 to give 2-[2-(hetarylidene)ethylidene]-1,3-dicarbonyl compounds 7-14. The result of the reactions between 1,2-dihydro-1-methyl-2-methylene-quinoline (Ia) and cyclic 1,3-dicarbonyl compounds depends on the nature of the dihydro intermediates A/B. Dehydrogenation of keton intermediates A results in 2-(1,2-dimethyl-4(1H)-quinolylidene)-1,3-dicarbonyl compounds 17-21. Enol intermediates B with 6-membered dicarbonyl ring form 6,12-methano-dibenz[d,g][1,3]oxazocinones 22-25. H-1 NM R spectra and X-ray structure analysis prove the structure of 23.
• Rosenhauer, Journal fur praktische Chemie (Leipzig 1954), 1924, vol. <2> 107, p. 236
  作者：Rosenhauer

  DOI：——

  日期：——