2-methyl-1-(1'-ethoxyethoxy)butyn-3-ol-2 | 250250-75-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-1-(1'-ethoxyethoxy)butyn-3-ol-2
• 英文别名: 1-(1-Ethoxyethoxy)-2-methylbut-3-yn-2-ol
• CAS: 250250-75-0
• 化学式: C₉H₁₆O₃
• 分子量: 172.224
• InChiKey: GUYGSHUTOMTOKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methyl-1-(1'-ethoxyethoxy)butyn-3-ol-2 在 盐酸 、 三乙胺 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 6.83h， 生成 diethyl 4-hydroxy-3-methylbuta-1,2-dien-1-ylphosphonate
  参考文献：
  名称：

  Synthesis of 4-Substituted-4-(Diethylphosphono)-2-Methylbuta-2,3-dien-1-oles

  摘要：

  Several I-substituted 4-(diethylphosphono)-2-methylbuta-2,3-dien-1-oles 4a-f were synthesized by a simple and efficient three-step procedure starting from acetylene derivatives.

  DOI：

  10.1080/00397919908085907
• 作为产物：
  描述：

  1-(1-ethoxy-ethoxy)-propan-2-one 、 乙炔 在 乙基溴化镁 作用下， 以 四氢呋喃 为溶剂， 反应 5.25h， 以50%的产率得到2-methyl-1-(1'-ethoxyethoxy)butyn-3-ol-2
  参考文献：
  名称：

  Synthesis of 4-Substituted-4-(Diethylphosphono)-2-Methylbuta-2,3-dien-1-oles

  摘要：

  Several I-substituted 4-(diethylphosphono)-2-methylbuta-2,3-dien-1-oles 4a-f were synthesized by a simple and efficient three-step procedure starting from acetylene derivatives.

  DOI：

  10.1080/00397919908085907

文献信息

• METHOD FOR ADDITION REACTION OF ACETYLENE AND KETONE COMPOUND
  申请人：ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD.

  公开号：US20220380280A1

  公开（公告）日：2022-12-01

  The disclosure discloses a method for an addition reaction of acetylene and a ketone compound. The method includes the following steps: S1, providing a continuous reaction device, wherein the continuous reaction device includes a plurality of bubble tubular reactors being connected with each other through connecting tubes; feeding a raw material solution containing the ketone compound and alkali into the plurality of bubble tubular reactors, and S3, under normal pressure, pumping acetylene from the bottom of the first bubble tubular reactor for the addition reaction. By applying the technical solution of the invention, acetylene reacts with the ketone compound in the plurality of bubble tubular reactors arranged in series, which can ensure the sufficient gas-liquid contact time, and thus making full use of the acetylene gas, improving the utilization rate thereof, effectively reduing the amount of acetylene, reducing costs, and further improving the safety.
• Synthesis of 4-Substituted-4-(Diethylphosphono)-2-Methylbuta-2,3-dien-1-oles
  作者：Valery K. Brel

  DOI：10.1080/00397919908085907

  日期：1999.11

  Several I-substituted 4-(diethylphosphono)-2-methylbuta-2,3-dien-1-oles 4a-f were synthesized by a simple and efficient three-step procedure starting from acetylene derivatives.