1-Pentyl-1,2,3,4-tetrahydroquinoline | 63074-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Pentyl-1,2,3,4-tetrahydroquinoline
• 英文别名: 1-pentyl-3,4-dihydro-2H-quinoline
• CAS: 63074-60-2
• 化学式: C₁₄H₂₁N
• 分子量: 203.327
• InChiKey: BZAQVGQKVHHGDT-UHFFFAOYSA-N

物化性质

• 沸点：
  315.3±11.0 °C(Predicted)
• 密度：
  0.948±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Pentyl-1,2,3,4-tetrahydroquinoline 在 2,2,6,6-四甲基哌啶氧化物 、 氧气 、 potassium carbonate 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以64%的产率得到1-pentyl-3,4-dihydro-2-quinolone
  参考文献：
  名称：

  Selective electrochemical oxidation of tetrahydroquinolines to 3,4-dihydroquinolones

  摘要：

  一种方法被开发出来，用O₂作为氧源，TEMPO作为氧化还原媒介，NaI不仅作为电解质，还作为氧化还原媒介，用于将四氢喹啉电化学氧化为3,4-二氢喹啉酮。

  DOI：

  10.1039/d2gc00162d
• 作为产物：
  描述：

  溴丁基-镁 、 1-(1H-1,2,3-Benzotriazol-1-ylmethyl)-1,2,3,4-tetrahydroquinoline 以 甲苯 为溶剂， 反应 24.0h， 以64%的产率得到1-Pentyl-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  波長変換のための高蛍光性光安定性発色団

  摘要：

  This invention provides a highly fluorescent material containing a single (i=0) or a series of (i=1, 2, etc.) complex ring systems. This chromophore is particularly useful for the absorption and emission of photons in the visible light wavelength range and near-infrared wavelength range. This chromophore, highly luminescent with photostability, has various applications, such as in wavelength conversion films. Wavelength conversion films have the potential to significantly improve the concentration efficiency of solar light in photovoltaic devices or solar cells.

  公开号：

  JP2016509621A

文献信息

• [EN] PROCESS FOR THE PREPARATION OF 4-AMINOINDANE DERIVATIVES AND RELATED AMINOINDANE AMIDES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE 4-AMINOINDANE ET D'AMIDES D'AMINOINDANE ASSOCIÉS
  申请人：STICHTING I-F PRODUCT COLLABORATION

  公开号：WO2017178868A1

  公开（公告）日：2017-10-19

  The present invention relates to a process for the preparation of 4-aminoindane derivatives of Formula (I) (I). The present invention also relates to a process for the preparation of aminoindane amides of Formula (II), having fungicidal activity, starting from a 4- aminoindane derivative intermediate of Formula (I) obtained through the above-mentioned process. (II).

  本发明涉及一种制备公式(I)所示的4-氨基吲哚烷衍生物的方法。本发明还涉及一种从通过上述方法获得的公式(I)所示的4-氨基吲哚烷衍生物中间体出发，制备具有杀菌活性的公式(II)所示的氨基吲哚烷酰胺的方法。
• Access to <i>gem</i>-Difluoro Olefins via C–H Functionalization and Dual Role of Anilines
  作者：Zhen Yang、Chao Pei、Rene M. Koenigs

  DOI：10.1021/acs.orglett.0c02568

  日期：2020.9.18

  In this Letter, we describe a simple, practical approach in which cheap CuI was used as a catalyst to introduce a gem-difluoro olefin onto simple electron-rich aniline derivatives in good yield via direct C–H functionalization and a subsequent HF elimination reaction. Detailed mechanistic studies point at a dual role of aniline derivatives in this reaction, which serve as a substrate and a basic promoter

  在这封信中，我们描述了一种简单，实用的方法，其中廉价的CuI用作催化剂，通过直接的C–H官能化和随后的HF消除反应，以良好的产率将宝石-二氟烯烃引入简单的富电子苯胺衍生物中。详细的机理研究指出，苯胺衍生物在该反应中起着双重作用，它们充当底物和触发HF消除步骤的基本启动子。
• [EN] CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS<br/>[FR] DERIVES DE CHROMENE A TITRE D'AGENTS ANTI-INFLAMMATOIRES
  申请人：PHARMACIA CORP

  公开号：WO2004087687A1

  公开（公告）日：2004-10-14

  The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (I). Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.

  该发明涉及在治疗与环氧合酶-2介导的疾病相关的情况中具有效用的方法和化合物。特别感兴趣的化合物是由式(I)定义的苯并吡喃和它们的类似物。其中Z、X、R1、R2、R3和R4如规范中所述。
• STABLE VIOLET-BLUE TO BLUE IMIDAZOLIUM COMPOUNDS
  申请人：The Procter & Gamble Company

  公开号：US20180072970A1

  公开（公告）日：2018-03-15

  Disclosed are novel stable violet-blue to blue imidazolium azo compounds that have a simplified chromophore and high relative solubility in aqueous systems, and that are stable under the conditions of use and storage. The compounds are useful for dyeing fibers such as fabrics and hair, as fabric hueing agents, and as dyes for other keratinaceous materials. Also disclosed are laundry care compositions comprising the imidazolium azo compounds and methods of using the compositions.

  本发明涉及一种新型的稳定的紫蓝至蓝色咪唑啉偶氮化合物，其具有简化的色团和在水系中具有较高的溶解度，且在使用和储存条件下稳定。这些化合物可用于染色纤维，如织物和头发，作为织物染色剂，以及用于其他角蛋白质材料的染料。还公开了包含咪唑啉偶氮化合物的洗涤护理组合物以及使用这些组合物的方法。
• [EN] ACYLATED INDOLINE AND TETRAHYDROQUINOLINE DERIVATIVES AS HCV INHIBITORS<br/>[FR] DERIVES ACYLES D'INDOLINES ET DE TETRAHYDROQUINOLEINES CONSTITUANT DES INHIBITEURS DU VHC
  申请人：GLAXO GROUP LTD

  公开号：WO2004096210A1

  公开（公告）日：2004-11-11

  Use of a compound of Formula (I) : wherein: R1 represents hydroxy or NR BRC; R2 represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; R3 represents aryl or heteroaryl; R4 represents one or two substituents independently selected from hydrogen, C1-6alkyl, halo, ORA, C(O)NRBRC, C(O)RD, CO2H , CO2RD, NRBRC, NREC(O)RD, NRECO2RD, NREC(O)NRFRG, NRESO2RD, SO2NRFRG, SO2RD, nitro, cyano, heterocyclyl, heteroaryl, aryl, arylalkyl heteroarylalkyl or CF3; R5 and R6 independently represent hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; R7 and R8 independently represent hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; n represents 0 or 1; RA represents hydrogen, C1-6alkyl, arylalkyl, heteroarylalkyl, aryl or heteroaryl; RB and RC independently represent hydrogen, C1-6alkyl, aryl or heteroaryl; or RB and RC together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; RD is selected from the group consisting of C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; RE represents hydrogen or C1-6alkyl; RF and RG are independently selected from the group consisting of hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; or RF and RG together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; and salts, solvates and esters thereof; provided that when R1 is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; in the manufacture of a medicament for the treatment of viral infection is provided. Also provided are certain novel compounds of Formula (I) represented by Formula (Ib). Further provided are processes for the preparation of compounds of Formula (I), pharmaceutical compositions comprising them, and methods of using them in HCV treatment.

  使用公式（I）的化合物：其中：R1代表羟基或NRBRC; R2代表C1-6烷基，杂环烷基烷基，芳基烷基或杂芳基烷基; R3代表芳基或杂芳基; R4代表一个或两个取代基，独立地选自氢，C1-6烷基，卤素，ORA，C（O）NRBRC，C（O）RD，CO2H，CO2RD，NRBRC，NREC（O）RD，NRECO2RD，NREC（O）NRFRG，NRESO2RD，SO2NRFRG，SO2RD，硝基，氰基，杂环烷基，杂芳基，芳基，芳基烷基，杂芳基烷基或CF3; R5和R6独立地表示氢，C1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; R7和R8独立地表示氢，C1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; n表示0或1; RA表示氢，C1-6烷基，芳基烷基，杂芳基烷基，芳基或杂芳基; RB和RC独立地表示氢，C1-6烷基，芳基或杂芳基; 或RB和RC与它们附着的氮原子一起形成5或6个成员的饱和环状基团; RD选自C1-6烷基，芳基，杂芳基，芳基烷基和杂芳基烷基; RE表示氢或C1-6烷基; RF和RG独立地选自氢，C1-6烷基，芳基，杂芳基，芳基烷基和杂芳基烷基; 或RF和RG与它们附着的氮原子一起形成5或6个成员的饱和环状基团; 以及其盐，溶剂化合物和酯; 假设当R1酯化形成-OR时，其中R选自直链或支链烷基，芳基烷基，芳氧烷基或芳基，那么R不是叔丁基; 提供用于制造用于治疗病毒感染的药物的方法。还提供由公式（Ib）表示的公式（I）的某些新化合物。还提供制备公式（I）化合物的方法，包括它们的制药组合物以及在HCV治疗中使用它们的方法。