1-(2,4-二氯苯氧基)丙-2-酮 | 17199-30-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2,4-二氯苯氧基)丙-2-酮
• 英文名称: (2,4-dichloro-phenoxy)-acetone
• 英文别名: (2,4-Dichlor-phenoxy)-aceton；1-(2,4-Dichlorphenoxy)propanon-2；2,4-Dichlorphenol-acetolether；2,4-Dimethylphenoxy-aceton；(2,4-Dichlorophenoxy)-2-propanone；1-(2,4-dichlorophenoxy)propan-2-one
• CAS: 17199-30-3
• 化学式: C₉H₈Cl₂O₂
• mdl: MFCD00116295
• 分子量: 219.067
• InChiKey: MQYQBKDURLWQTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2914700090

反应信息

• 作为反应物：
  描述：

  1-(2,4-二氯苯氧基)丙-2-酮 在 sodium tetrahydroborate 、 氯化亚砜 、 sodium ethanolate 、 potassium carbonate 、 溶剂黄146 、 三乙胺 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 丙酮 、 苯 为溶剂， 反应 40.0h， 生成 1-Cyclopropyl-5-(2,4-dichlorophenoxy)-2-(phenoxymethyl)pyridin-4-one
  参考文献：
  名称：

  Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent

  摘要：

  We report the discovery, synthesis, and biological activities of phenoxy-4-pyrone and phenoxy-4-pyridone derivatives as novel inhibitors of enoyl-acyl carrier protein reductase (FabI). Pyridone derivatives showed better activities than pyrone derivatives against FabI and Staphylococcus aureus strains, including methicillin-resistant Staphylococcus aureus (MRSA). Among the pyridone derivatives, compound 16l especially exhibited promising activities against the MRSA strain and good pharmacokinetic profiles. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.08.077
• 作为产物：
  描述：

  一氯丙酮 、 2,4-二氯酚 在 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 为溶剂， 生成 1-(2,4-二氯苯氧基)丙-2-酮
  参考文献：
  名称：

  氨基乙腈衍生物的发现，这是一类新型的合成驱虫药。

  摘要：

  已经发现了一系列新的氨基乙腈衍生物（AAD），它们对寄生的线虫物种（例如，弯扭线虫和棒状毛线虫）表现出较高的驱虫活性。重要的是，这些化合物还显示出抗线虫菌株的活性，该菌株对目前可用的广谱驱虫药具有抗性。介绍了其发现，合成，构效关系和生物学结果。

  DOI：

  10.1016/j.bmcl.2008.03.071

文献信息

• KETONE OR OXIME COMPOUND, AND HERBICIDE
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20170347647A1

  公开（公告）日：2017-12-07

  There is provided novel agricultural chemicals, in particular herbicides. A ketone or oxime compound or a salt thereof of Formula (1): wherein B is a ring of any one of B-1, B-2, or B-3, Q is an oxygen atom, a sulfur atom, NOR 7 , etc., R 6 is a hydrogen atom, C 1-6 alkyl, etc., R 7 is a hydrogen atom, C 1-6 alkyl, etc., R 8a , R 8b , R 9a , R 9b , R 10 , R 11 , R 12 , R 13 , and R 14 are each independently a hydrogen atom, C 1-6 alkyl, etc., m is an integer of 1 or 2, n is an integer of 0, 1 or 2; and a herbicide including the compound or salt thereof.

  提供了新型农业化学品，特别是除草剂。化合物或其盐的酮或肟化合物的公式（1）：其中B是B-1、B-2或B-3中的任意一个环，Q是氧原子、硫原子、NOR7等，R6是氢原子、C1-6烷基等，R7是氢原子、C1-6烷基等，R8a、R8b、R9a、R9b、R10、R11、R12、R13和R14各自独立地是氢原子、C1-6烷基等，m是1或2的整数，n是0、1或2的整数；以及包括该化合物或其盐的除草剂。
• CRTH2 Receptor Ligands For Medicinal Uses
  申请人：Ulven Trond

  公开号：US20090099189A1

  公开（公告）日：2009-04-16

  Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic rhinobronchitis, wherein A represents a carboxyl group —COON, or a carboxyl bioisostere; A 1 , is hydrogen or methyl; ring Ar 1 is an optionally substituted phenyl ring 5- or 6-membered monocyclic heteroaryl ring, in which AA 1 CHO— and L2 are linked to adjacent ring atoms; rings Are 2 , Ar 3 each independently represent a phenyl or 5- or 6-membered monocyclic heteroaryl ring, or a bicyclic ring system consisting of a 5- or 6-membered carbocyclic or heterocyclic ring which is benz-fused or fused to a 5- or 6-membered monocyclic heteroaryl ring, said ring or ring system being optionally substituted; t is 0 or 1; L2 and L3 are linker radicals as defined in the description.

  式(I)的化合物可用于治疗对CRTH2受体活性调节敏感的疾病，例如哮喘、鼻炎、过敏性气道综合症和过敏性鼻支气管炎，其中A代表羧基—COON或羧基生物同位素；A1为氢或甲基；环Ar1是一个可选取代的苯环5-或6-成员的单环杂环，其中AA1CHO—和L2与相邻的环原子连接；环Are2，Ar3各自独立地表示一个苯环或5-或6-成员的单环杂环，或由一个5-或6-成员的碳环或杂环组成的双环系统，该环或环系统被苯并或与一个5-或6-成员的单环杂环融合，该环或环系统是可选取代的；t为0或1；L2和L3是如描述中所定义的连接基团。
• Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels
  申请人：Gonzalez, III Jesus E.

  公开号：US20100087479A1

  公开（公告）日：2010-04-08

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及一种作为电压门控钠离子通道抑制剂有用的化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物，并提供了使用这些组合物治疗各种疾病的方法。
• COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS
  申请人：Gonzalez, III Jesus E.

  公开号：US20120238578A1

  公开（公告）日：2012-09-20

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及用作电压门控钠通道抑制剂的化合物。本发明还提供了包括本发明化合物的药学上可接受的组合物以及使用这些组合物治疗各种疾病的方法。
• Novel herbicide resistance genes
  申请人：Dow AgroSciences LLC

  公开号：EP2298901A2

  公开（公告）日：2011-03-23

  The subject invention provides novel plants that are not only resistant to 2,4-D and other phenoxy auxin herbicides, but also to aryloxyphenoxypropionate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention alone or "stacked" together with another herbicide resistance gene, preferably a glyphosate. resistance gene, so as to provide broader and more robust weed control, increased treatment flexibility, and improved herbicide resistance management options. More specifically, preferred enzymes and genes for use according to the subject invention are referred to herein as AAD (aryloxyalkanoate dioxygenase) genes and proteins. No α-ketoglutarate-dependent dioxygenase enzyme has previously been reported to have the ability to degrade herbicides of different chemical classes and modes of action. This highly novel discovery is the basis of significant herbicide tolerant crop trait opportunities as well as development of selectable marker technology. The subject invention also includes related methods of controlling weeds. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the formation of, and controlling, weeds that are resistant (or naturally more tolerant) to one or more herbicides such as glyphosate.

  本发明提供的新型植物不仅能抗 2,4-D 和其他苯氧基助剂除草剂，还能抗芳基氧基苯氧基丙酸酯除草剂。在此之前，人们并不期望或认为通过引入单一基因就能培育出同时具有这两种优势特性的植物。本发明还包括单独产生一种或多种本发明酶的植物，或与另一种除草剂抗性基因（最好是草甘膦抗性基因）"叠加 "在一起的植物，从而提供更广泛、更强大的杂草控制，增加处理的灵活性，改进除草剂抗性管理选择。更具体地说，根据本发明使用的优选酶和基因在此称为 AAD（芳氧基烷酸二加氧酶）基因和蛋白。以前没有报道过依赖于α-酮戊二酸的二加氧酶具有降解不同化学类别和作用方式的除草剂的能力。这一高度新颖的发现是重要的耐除草剂作物性状机会以及可选择标记技术发展的基础。本发明还包括控制杂草的相关方法。本发明可使除草剂的新组合以新的方式使用。此外，本发明还提供了防止形成和控制对一种或多种除草剂（如草甘膦）具有抗性（或天然更耐受）的杂草的新方法。