1-Phenyl-3-(2-phenyl-1,3-dithiolan-2-yl)propan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Phenyl-3-(2-phenyl-1,3-dithiolan-2-yl)propan-1-one
• 化学式: C₁₈H₁₈OS₂
• 分子量: 314.472
• InChiKey: UQFYNMGYEFHVSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  半胱胺盐酸盐 、 1-Phenyl-3-(2-phenyl-1,3-dithiolan-2-yl)propan-1-one 在 吡啶 作用下， 反应 14.0h， 生成 2-Phenyl-2-(2-(2-phenyl-1,3-dithiolan-2-yl)ethyl)thiazolidine
  参考文献：
  名称：

  New γ-thiazolidine-1,3-dithiolanes as radioprotectors

  摘要：

  Fourteen gamma-thiazolidine-1,3-dithiolanes were prepared and tested as radioprotective agents. The combination within a single molecule of thiazolidine and dithiolane moieties, both of which are known for their radioprotective properties, was achieved for the first time. Several molecules show significant radioprotective activity: immediate 4l; delayed 4b, 4f, 4h; or immediate and prolonged 4a.

  DOI：

  10.1016/0223-5234(94)90208-9
• 作为产物：
  描述：

  1,2-乙二硫醇 、 1,2-联苯甲酰乙烷 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 6.0h， 生成 2,2'-diphenyl-2,2'-ethane-1,2-diyl-bis-[1,3]dithiolane 、 1-Phenyl-3-(2-phenyl-1,3-dithiolan-2-yl)propan-1-one
  参考文献：
  名称：

  New γ-thiazolidine-1,3-dithiolanes as radioprotectors

  摘要：

  Fourteen gamma-thiazolidine-1,3-dithiolanes were prepared and tested as radioprotective agents. The combination within a single molecule of thiazolidine and dithiolane moieties, both of which are known for their radioprotective properties, was achieved for the first time. Several molecules show significant radioprotective activity: immediate 4l; delayed 4b, 4f, 4h; or immediate and prolonged 4a.

  DOI：

  10.1016/0223-5234(94)90208-9