2,4,6,8-四甲基-2,4,6,8-四[3-(环氧乙烷基甲氧基)丙基]环四硅氧烷 | 60665-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 中文名称: 2,4,6,8-四甲基-2,4,6,8-四[3-(环氧乙烷基甲氧基)丙基]环四硅氧烷
• 英文名称: 1,3,5,7-tetrakis(2-glycidyloxypropyl)-1,3,5,7-tetramethylcyclo-tetrasiloxane
• 英文别名: 2,4,6,8-Tetramethyl-2,4,6,8-tetrakis(3-(oxiranylmethoxy)propyl)cyclotetrasiloxane；2,4,6,8-tetramethyl-2,4,6,8-tetrakis[3-(oxiran-2-ylmethoxy)propyl]-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
• CAS: 60665-85-2
• 化学式: C₂₈H₅₆O₁₂Si₄
• 分子量: 697.087
• InChiKey: BLZDTVROPKIJLZ-UHFFFAOYSA-N

物化性质

• 沸点：
  603.5±65.0 °C(Predicted)
• 密度：
  1.132 g/mL at 25 °C
• 闪点：
  >200℃

计算性质

• 辛醇/水分配系数(LogP)：
  3.58
• 重原子数：
  44
• 可旋转键数：
  24
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  12

安全信息

• WGK Germany：
  3

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : 2,4,6,8-Tetramethyl-2,4,6,8-tetrakis(propyl glycidyl
ether)cyclotetrasiloxane
CAS-No. : 60665-85-2
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Oral (Category 4)
Skin irritation (Category 2)
Eye irritation (Category 2)
Skin sensitization (Category 1)
Specific target organ toxicity - single exposure (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Harmful if swallowed. May cause sensitization by skin contact. Irritating to eyes, respiratory system and
skin. Irritating to skin.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
H302 Harmful if swallowed.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s)
P261 Avoid breathing vapours.
P280 Wear protective gloves.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R22 Harmful if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.
R43 May cause sensitization by skin contact.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36/37 Wear suitable protective clothing and gloves.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms : CS-697
Polyglycidyl ether cyclosiloxane
Tetrakis(propyl glycidyl ether) cyclomethylsiloxane
Formula : C28H56O12Si4
Molecular Weight : 697,08 g/mol
Component Concentration
2,4,6,8-Tetramethyl-2,4,6,8-tetrakis(propyl glycidyl ether)cyclotetrasiloxane
CAS-No. 60665-85-2 -
EC-No. 262-360-7

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, silicon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.
Evacuate personnel to safe areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature: 2 - 8 °C
Specific end use(s)
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point > 200 °C
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density 1,1321 g/cm3 at 25 °C
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Toluene)
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion Harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine Pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

---

Section 16. OTHER INFORMATION
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

反应信息

• 作为反应物：
  描述：

  2,4,6,8-四甲基-2,4,6,8-四[3-(环氧乙烷基甲氧基)丙基]环四硅氧烷 、 甲基丙烯酸 在 4-二甲氨基吡啶 、 2,6-二叔丁基-4-甲基苯酚 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 Methacryl trisepoxy cyclosiloxane
  参考文献：
  名称：

  Adhesive compositions containing cyclic siloxanes and methods for use thereof

  摘要：

  这项发明是基于发现，某些明确定义的官能化环状硅氧烷可用作电子封装行业的热固性树脂。本文描述的官能化环状硅氧烷化合物可以通过多种方式固化，具体取决于化合物中所包含的可聚合基团。发明的环状硅氧烷可通过将多聚烷基（氢）环硅氧烷与适当官能化的烯烃和/或炔烃进行氢硅烷化而轻松制备。

  公开号：

  US07777064B2
• 作为产物：
  描述：

  烯丙基缩水甘油醚 、 2,4,6,8-四甲基环四硅氧烷 在 铂 作用下， 生成 2,4,6,8-四甲基-2,4,6,8-四[3-(环氧乙烷基甲氧基)丙基]环四硅氧烷
  参考文献：
  名称：

  New Gel-Like Polymers as Selective Weak-Base Anion Exchangers

  摘要：

  我们合成了一组基于多胺荚膜并具有出色离子结合能力的新型阴离子交换剂。这些材料是通过各种聚（乙烯胺）与环四硅氧烷的缩水甘油衍生物反应而获得的。最终的高分子强交联材料形成凝胶状固体。通过光谱方法（CP-MAS NMR、FR-IR、UV-Vis）研究了它们的结构以及与吸附的阴离子之间的相互作用。确定了 29 种阴离子的吸附等温线和动力学参数。所研究的材料对一些重要的阴离子（如硒酸盐（VI）或过铼酸盐）具有较高的离子容量和选择性。

  DOI：

  10.1371/journal.pone.0122891
• 作为试剂：
  描述：

  烯丙基缩水甘油醚 、 2,4,6,8-四甲基环四硅氧烷 在 氯铂酸 crude product 、 2,4,6,8-四甲基-2,4,6,8-四[3-(环氧乙烷基甲氧基)丙基]环四硅氧烷 作用下， 以 二乙二醇二甲醚 为溶剂， 60.0~335.0 ℃ 、13.33 kPa 条件下， 生成 2,4,6,8-四甲基-2,4,6,8-四[3-(环氧乙烷基甲氧基)丙基]环四硅氧烷
  参考文献：
  名称：

  Hydrophilic silicone rubber article and process for its preparation

  摘要：

  部分或全部表面通过与有机硅氧烷反应（平衡反应）而变得亲水的亲水性硅橡胶制品，该有机硅氧烷是通过含有SiH基团的硅氧烷与含有保护羟基的烯丙基化合物反应合成的。这些制品特别适用于隐形眼镜和人工晶体。

  公开号：

  US04920184A1

文献信息

• Glycidyl alkoxysilane reactivities towards simple nucleophiles in organic media for improved molecular structure definition in hybrid materials
  作者：X. Guillory、A. Tessier、G.-O. Gratien、P. Weiss、S. Colliec-Jouault、D. Dubreuil、J. Lebreton、J. Le Bideau

  DOI：10.1039/c6ra01658h

  日期：——

  For hybrid materials, the relationship between the macroscopic properties and the molecular structures and dynamics at the microscopic between the organic and inorganic components level is crucial. The characterization of these components as well as their reactivity have to be emphasized in order to design and synthesize improved hybrids. We report herein the first comprehensive study of the reactivity

  对于杂化材料，有机和无机成分之间的宏观特性与分子结构和微观动力学之间的关系至关重要。为了设计和合成改良的杂种，必须强调这些成分的特征及其反应性。我们在此报告了对（3-环氧丙氧基丙基）三烷氧基硅烷在有机介质中的反应性的首次全面研究，该反应被广泛用作溶胶-凝胶杂化合成的前体，对常见的亲核试剂。对反应的深入研究使我们能够对环氧和烷氧基硅烷官能团的反应性得出清晰的结论。此外，亲核试剂的性质和活化方法对反应结果有很大的影响，在某些情况下会发现意外结果。还研究了烷氧基残基（甲氧基，乙氧基…）性质的重要性，突出了对缩水甘油基硅烷衍生物（GPTMS，GPTES和PECS）的化学选择性反应，并建立了一个新的原始溶胶-凝胶前体库。
• WO2007/100329
  申请人：——

  公开号：——

  公开（公告）日：——
• New polymeric metal ion scavengers with polyamine podand moieties
  作者：Błażej Gierczyk、Grzegorz Schroeder、Michał Cegłowski

  DOI：10.1016/j.reactfunctpolym.2011.01.007

  日期：2011.4

  A group of new, transition metal cation scavengers based on polyamine podands and of excellent ion-binding capacity, were synthesized. Their structures as well as the structures of their complexes with metal ions were studied by spectroscopic methods. The isotherms of cation binding and kinetics of this process were studied. The materials obtained were also characterized by thermal methods. (C) 2011 Elsevier Ltd. All rights reserved.
• Adhesive compositions containing cyclic siloxanes and methods for use thereof
  申请人：Designer Molecules, Inc.

  公开号：US07777064B2

  公开（公告）日：2010-08-17

  The invention is based on the discovery that certain well-defined functionalized cyclic siloxanes are useful as thermosetting resins for the electronic packaging industry. The functionalized cyclic siloxane compounds described herein can be cured in a variety of ways, depending on the polymerizable moiety incorporated into the compound. Invention cyclic siloxanes are readily prepared via hydrosilation of polyalkyl(hydro)cyclosiloxanes with appropriately functionalized alkenes and/or alkynes.

  这项发明是基于发现，某些明确定义的官能化环状硅氧烷可用作电子封装行业的热固性树脂。本文描述的官能化环状硅氧烷化合物可以通过多种方式固化，具体取决于化合物中所包含的可聚合基团。发明的环状硅氧烷可通过将多聚烷基（氢）环硅氧烷与适当官能化的烯烃和/或炔烃进行氢硅烷化而轻松制备。
• New Gel-Like Polymers as Selective Weak-Base Anion Exchangers
  作者：Błażej Gierczyk、Michał Cegłowski、Maciej Zalas

  DOI：10.1371/journal.pone.0122891

  日期：——

  A group of new anion exchangers, based on polyamine podands and of excellent ion-binding capacity, were synthesized. The materials were obtained in reactions between various poly(ethyleneamines) with glycidyl derivatives of cyclotetrasiloxane. The final polymeric, strongly cross-linked materials form gel-like solids. Their structures and interactions with anions adsorbed were studied by spectroscopic methods (CP-MAS NMR, FR-IR, UV-Vis). The sorption isotherms and kinetic parameters were determined for 29 anions. Materials studied show high ion capacity and selectivity towards some important anions, e.g., selenate(VI) or perrhenate.

  我们合成了一组基于多胺荚膜并具有出色离子结合能力的新型阴离子交换剂。这些材料是通过各种聚（乙烯胺）与环四硅氧烷的缩水甘油衍生物反应而获得的。最终的高分子强交联材料形成凝胶状固体。通过光谱方法（CP-MAS NMR、FR-IR、UV-Vis）研究了它们的结构以及与吸附的阴离子之间的相互作用。确定了 29 种阴离子的吸附等温线和动力学参数。所研究的材料对一些重要的阴离子（如硒酸盐（VI）或过铼酸盐）具有较高的离子容量和选择性。