2-氰基-5-羟基吡啶 | 86869-14-9

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氰基-5-羟基吡啶
• 中文别名: 5-羟基吡啶-2-氰基
• 英文名称: 5-hydroxypicolinonitrile
• 英文别名: 5-hydroxypyridine-2-carbonitrile；2-cyano-5-hydroxypyridine
• CAS: 86869-14-9
• 化学式: C₆H₄N₂O
• 分子量: 120.111
• InChiKey: YUEKWNYGXNDQRO-UHFFFAOYSA-N

物化性质

• 沸点：
  429.2±30.0 °C(Predicted)
• 密度：
  1.33
• 闪点：
  213℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.9
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 安全说明：
  S24/25
• 海关编码：
  2933399090
• 危险性防范说明：
  P280,P305+P351+P338,P310
• 危险性描述：
  H302,H315,H319,H332,H335
• 储存条件：
  室温

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 2-Cyano-5-hydroxypyridine
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 2-Cyano-5-hydroxypyridine
CAS number: 86869-14-9

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H4N2O
Molecular weight: 120.1

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氰基-5-羟基吡啶 在 sodium cyanide 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.5h， 生成 5-[5-(1-methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dione
  参考文献：
  名称：

  发现2-羟基苯乙酮衍生物作为增强肝X受体激动剂的效能和β-选择性的杰出连接子

  摘要：

  我们的研究发现，2-羟基苯乙酮衍生物是1,1-双三氟甲基甲醇部分与咪唑烷-2,4-二酮部分之间的杰出连接子，可增强我们肝脏X受体激动剂的效力和β选择性。到尾的分子设计。在GAL-4萤光素酶试验中，此连接子的掺入对LXRβ激动活性（EC 50）的效力比我们先前的化合物（2）高20倍。此外，我们还确定了5- [5-（5-（1-甲基乙氧基）吡啶基-2-基] -5-甲基咪唑啉-2,4-二酮（54），它降低了2-羟基苯乙酮衍生物的亲脂性。我们发现，我们新开发的接头和乙内酰脲（54）在提高LXRβ的效力和选择性方面起着关键作用。光学分离的（-）- 56在不增加血浆甘油三酸酯水平的情况下增加了高密度脂蛋白胆固醇的水平，并导致在高脂和胆固醇喂养的低密度脂蛋白受体敲除中主动脉弓内脂质积聚区域的减少出老鼠。在此手稿中，我们报道（-）- 56是一种高度有效的β选择性LXR激动剂，可用于治疗动脉粥样硬化。

  DOI：

  10.1016/j.bmc.2016.05.048
• 作为产物：
  描述：

  2-溴-5-硝基吡啶 在 硫酸 、 铁粉 、 溶剂黄146 作用下， 以 水 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 11.67h， 生成 2-氰基-5-羟基吡啶
  参考文献：
  名称：

  2-氰基-5-羟基吡啶的制备方法

  摘要：

  本发明涉及一种2‑氰基‑5‑羟基吡啶的制备方法。该方法是以2‑溴‑5‑硝基吡啶、NaCN、CuCN、二甲基甲酰胺和KH2PO4等为起始原料，先生成2‑氰基‑5‑硝基吡啶；再加入乙酸乙酯和适量还原Fe粉，以及足够量的醋酸；最后再加入适量的H2SO4溶液和NaNO2，过滤干燥最终得橙黄色固体2‑氰基‑5‑羟基吡啶。该方法原料易得，反应条件温和，成本低，适宜于工厂大规模生产。

  公开号：

  CN106810494A

文献信息

• NOVEL INHIBITORS OF BETA-LACTAMASE
  申请人：Dininno Frank

  公开号：US20100279983A1

  公开（公告）日：2010-11-04

  This invention provides novel β-lactamase inhibitors of the aryl- and heteroarylsulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammonium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazidime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.

  这项发明提供了一种新型的β-内酰胺酶抑制剂，属于芳基和杂芳基磺酰胺基甲基膦酸单酯类，具有基于氮的阳离子或季铵基团。这些化合物抑制三类β-内酰胺酶，并增强β-内酰胺类抗生素（如亚胺培南和头孢他啶）对那些通常对β-内酰胺类抗生素具有抗药性的微生物的抗菌效果，这是由于β-内酰胺酶的存在。公式（I）或其药学上可接受的盐。
• [EN] TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS<br/>[FR] INHIBITEURS TRICYCLIQUES DE GYRASE UTILISABLES COMME AGENTS ANTIBACTÉRIENS
  申请人：TRIUS THERAPEUTICS INC

  公开号：WO2014043272A1

  公开（公告）日：2014-03-20

  Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

  本文披露了具有化学式I结构的化合物及其药用盐、酯和前药，这些化合物可用作抗菌有效的三环酶抑制剂。此外，本文还披露了三环酶抑制剂化合物的种属。还考虑了相关的药用组合物、用途和制备这些化合物的方法。
• Inhibitors of c-Jun N-terminal kinases
  申请人：Liu Gang

  公开号：US20060173050A1

  公开（公告）日：2006-08-03

  The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

  本发明涉及作为c-jun N-末端激酶1、2或3（JNK1、JNK2或JNK3）抑制剂的化合物，包含这些化合物的组合物以及这些化合物在预防或治疗由JNK1、JNK2和JNK3激活调控的疾病中的用途。
• [EN] METHODS FOR INDUCING BIOORTHOGONAL REACTIVITY<br/>[FR] PROCÉDÉS POUR INDUIRE UNE RÉACTIVITÉ BIO-ORTHOGONALE
  申请人：FOX JOSEPH

  公开号：WO2017106427A1

  公开（公告）日：2017-06-22

  A method for catalytically converting a dihydrotetrazine 1 into a tetrazine 2, wherein one R group on the dihydrotetrazine 1 is a substituted or unsubstituted aryi, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl, or heteroatom-containing group, and the other R group is selected from the group consisting of H and substituted or unsubstituted aryl, heteroaryl, alkyl, alkenyl, alkynyl, carbonyl,-or heteroatom-containing groups; 1, 2 wherein the method comprises oxidizing dihydrotetrazine 1 in a reaction medium in the presence of a catalyst and a stoichiometric oxidant.

  将二氢四氮唑1催化转化为四氮唑2的方法，其中二氢四氮唑1上的一个R基团是取代或未取代的芳基、杂环芳基、烷基、烯基、炔基、羰基或含杂原子的基团，另一个R基团选自H和取代或未取代的芳基、杂环芳基、烷基、烯基、炔基、羰基或含杂原子的基团；其中该方法包括在反应介质中在催化剂和化学计量氧化剂的存在下氧化二氢四氮唑1。
• 抑制SSAO/VAP-1的胺类化合物及其在医药 上的应用
  申请人：广东东阳光药业有限公司

  公开号：CN109251166B

  公开（公告）日：2021-11-05

  本发明涉及一种用于抑制氨基脲敏感性氧化酶(SSAO)和/或血管黏附蛋白‑1(VAP‑1)抑制剂的胺类化合物及其在医药上的应用，进一步涉及包含所述化合物的药物组合物。本发明所述的化合物及药物组合物可用于治疗炎症和/或炎症相关疾病、糖尿病和/或糖尿病相关疾病、精神病症、缺血性疾病、血管疾病、纤维化或组织移植排斥。