9-fluoro-8-hydroxy-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-fluoro-8-hydroxy-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
• 英文别名: 6,7-dihydro-9-fluoro-8-hydroxy-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid；7-fluoro-8-hydroxy-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
• 化学式: C₁₄H₁₂FNO₄
• 分子量: 277.252
• InChiKey: JZLWQSFBRJQQBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  硫酸二乙酯 、 9-fluoro-8-hydroxy-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid 在 sodium hydroxide 、 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 生成 6,7-dihydro-8-ethoxy-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
  参考文献：
  名称：

  Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]q

  摘要：

  8-烷氧基-6,7-二氢-5-甲基-9-氟-1-氧代-1H,5H-苯并[ij]喹诺啉-2-羧酸被披露为具有广谱活性的强效抗菌剂。还披露了酯类、酰氯、酰胺、烷基氨基烷基酯盐和药用可接受的羧酸盐。还描述了使用这些化合物的方法、包含这些化合物的药物组合物以及用于制备这些化合物的合成中间体。

  公开号：

  US04472407A1

文献信息

• [EN] PURES-(-)-9-FLUORO-6,7-DIHYDRO-8-(4-HYDROXYPIPERIDIN-1-YL)-5-METHYL-1-OXO-1H,-5H-BENZO[I,J]QUINOLIZINE-2- CARBOXYLIC ACID L-ARGININE SALT TETRAHYDRATE AND A PROCESS FOR ITS PREPARATION<br/>[FR] SEL PUR TÉTRAHYDRATÉ DE L-ARGININE D'ACIDE S-(-)-9-FLUORO-6,7-DIHYDRO- 8-(4-HYDROXYPIPÉRIDIN-1-YL)-5-MÉTHYL-1-OXO-1H,-5H-BENZO[I,J]QUINOLIZINE- 2-CARBOXYLIQUE
  申请人：WOCKHARDT LTD

  公开号：WO2013046061A1

  公开（公告）日：2013-04-04

  Pure S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,- 5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate and a process for its preparation is disclosed.

  本发明公开了纯S-(-)-9-氟-6,7-二氢-8-(4-羟基哌啶-1-基)-5-甲基-1-氧代-1H,-5H-苯并[i,j]喹啉-2-羧酸L-精氨酸盐四水合物及其制备方法。
• PURES-(-)-9-FLUORO-6,7-DIHYDRO-8-(4-HYDROXYPIPERIDIN-1-YL)-5-METHYL-1-OXO-1H,-5H-BENZO[I,J]QUINOLIZINE-2- CARBOXYLIC ACID L-ARGININE SALT TETRAHYDRATE AND A PROCESS FOR ITS PREPARATION
  申请人：Gangakhedkar Kiran Kumar

  公开号：US20140296280A1

  公开（公告）日：2014-10-02

  Pure S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,-5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate and a process for its preparation is disclosed.

  本发明公开了纯的S-(−)-9-氟-6,7-二氢-8-(4-羟基哌啶-1-基)-5-甲基-1-氧代-1H,-5H-苯并[i,j]喹啉-2-羧酸L-精氨酸盐四水合物及其制备方法。
• Precursors of 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]q
  申请人：Riker Laboratories, Inc.

  公开号：US04568750A1

  公开（公告）日：1986-02-04

  The compounds 5-bromo-6-fluoroquinaldine, 5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine, 1-acetyl-5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine and diethyl 2-[N-(6-fluoro-5-methoxy-1,2,3,4-tetrahydroquinaldinyl)]-methylenemalonate are intermediates for preparing antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]-quinolizine-2 -carboxylic acids.

  以下是翻译的结果： 化合物5-溴-6-氟喹啉，5-溴-6-氟-1,2,3,4-四氢喹啉，1-乙酰基-5-溴-6-氟-1,2,3,4-四氢喹啉和二乙基2-[N-(6-氟-5-甲氧基-1,2,3,4-四氢喹啉基)]-亚甲基丙二酸酯是制备抗菌8-烷氧基-6,7-二氢-5-甲基-9-氟-1-氧代-1H,5H-苯并[ij]-喹啉-2-羧酸的中间体。
• 8-Alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acids
  申请人：RIKER LABORATORIES, INCORPORATED

  公开号：EP0119779A1

  公开（公告）日：1984-09-26

  The 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo--1H,5H-benzo[ij]quinolizine-2-carboxylic acids are disclosed as potent antimicrobial agents with a broad spectrum of activity. Esters, acyl chlorides, amides, alkylaminoalkyl ester salts and pharmaceutically acceptable carboxylate salts are also disclosed. Methods of using these compounds, pharmaceutical compositions comprising these compounds and synthetic intermediates for preparing these compounds are also described.

  公开了 8-烷氧基-6,7-二氢-5-甲基-9-氟-1-氧代-1H,5H-苯并[ij]喹嗪-2-羧酸，它们是具有广谱活性的强效抗菌剂。 此外，还公开了酯类、酰基氯化物、酰胺、烷基氨基烷基酯盐和药学上可接受的羧酸盐。 还描述了使用这些化合物的方法、包含这些化合物的药物组合物以及制备这些化合物的合成中间体。
• ANTIBACTERIAL COMPOSITIONS
  申请人：Wockhardt Limited

  公开号：EP3435976B1

  公开（公告）日：2021-03-10