3-(4-Methoxyphenyl)pentanedial | 1215184-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4-Methoxyphenyl)pentanedial
• CAS: 1215184-15-8
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: YQKTYVLGDJFEOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-Methoxyphenyl)pentanedial 在 盐酸 、 氢气 、 sodium acetate 、 palladium(II) hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors

  摘要：

  The structure-activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate beta-amyloid peptide synthesis via gamma-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficacious in reducing the cortical A beta x-40 levels in FVB mice via a single PO dose, as well as sulfonamide-pyrazoles that exhibit selectivity for inhibition of APP versus Notch processing by gamma-secretase, are highlighted. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.08.008
• 作为产物：
  描述：

  4-甲氧基苯甲醛 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 sodium periodate 、 四氧化锇 、 四氯化钛 、 N-甲基吗啉氧化物 作用下， 以 四氢呋喃 、 硝基甲烷 、 二氯甲烷 、 水 、 丙酮 为溶剂， 生成 3-(4-Methoxyphenyl)pentanedial
  参考文献：
  名称：

  Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors

  摘要：

  The structure-activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate beta-amyloid peptide synthesis via gamma-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficacious in reducing the cortical A beta x-40 levels in FVB mice via a single PO dose, as well as sulfonamide-pyrazoles that exhibit selectivity for inhibition of APP versus Notch processing by gamma-secretase, are highlighted. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.08.008

文献信息

• Matrix stabilized enzyme crystals and methods of use
  申请人：——

  公开号：US20020182201A1

  公开（公告）日：2002-12-05

  The invention relates to the stabilization of enzymes through the formation of matrix stabilized enzyme crystals. A matrix stabilized enzyme crystal is formed through cross-linking a polymer having one or more reactive moieties with an enzyme crystal using a low concentration of a multi-functional cross-linking reagent. The invention includes matrix stabilized enzyme crystals of phenylalanine ammonia lyase and a method of using to treat hyperphenylalaninemia.

  本发明涉及通过形成基质稳定酶晶体来稳定酶。基质稳定酶晶体是通过使用低浓度的多功能交联试剂将具有一个或多个活性分子的聚合物与酶晶体交联而形成的。本发明包括苯丙氨酸氨裂解酶的基质稳定化酶晶体和用于治疗高苯丙氨酸血症的方法。
• MATRIX STABILIZED ENZYME CRYSTALS AND METHODS OF USE
  申请人：IBEX TECHNOLOGIES

  公开号：EP1372703A2

  公开（公告）日：2004-01-02
• N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS
  申请人：Elan Pharmaceuticals Inc.

  公开号：EP2346863A2

  公开（公告）日：2011-07-27
• US4742068A
  申请人：——

  公开号：US4742068A

  公开（公告）日：1988-05-03
• [EN] MATRIX STABILIZED ENZYME CRYSTALS AND METHODS OF USE<br/>[FR] CRISTAUX D'ENZYMES À STABILISATION MATRICIELLE ET MODALITÉS D'UTILISATION
  申请人：IBEX TECHNOLOGIES

  公开号：WO2002070646A2

  公开（公告）日：2002-09-12

  The invention relates to the stabilization of enzymes through the formation of matrix stabilized enzyme crystals. A matrix stabilized enzyme crystal is formed through cross-linking a polymer having one or more reactive moieties with an enzyme crystal using a low concentration of a multi-functional cross-linking reagent. The invention includes matrix stabilized enzyme crystals of phenylalanine ammonia lyase and a method of using to treat hyperphenylalaninemia.