2',9-O-diacetyl josamycin | 22875-07-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2',9-O-diacetyl josamycin
• 英文别名: Leucomycin A1 acetate；[(2S,3S,4R,6S)-6-[(2R,3S,4S,5R,6S)-5-acetyloxy-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-diacetyloxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate
• CAS: 22875-07-6
• 化学式: C₄₆H₇₃NO₁₇
• 分子量: 912.082
• InChiKey: BWDIUZRYHTUVBC-SRJDQKDASA-N

物化性质

• 沸点：
  882.1±65.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  64
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  218
• 氢给体数：
  1
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  2',9-O-diacetyl josamycin 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 以67.3%的产率得到2′,9-O-diacetyl-desmycarosyl josamycin
  参考文献：
  名称：

  Two novel N-glycoside 17, 18-unsaturated acid quinolin-3-ylmethyl ester josamycin derivatives

  摘要：

  A facile procedure was developed to synthesize novel N-glycoside josamycin derivatives by coupling 4'-amino-desmycarosyl josamycin derivatives with L-mycarose. A novel N-glycoside josamycin derivative 10a and a key intermediate 9a were designed and synthesized. And two rearranged compounds 9b and 10b were also got. (C) 2018 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2018.02.027
• 作为产物：
  描述：

  乙酸酐 、 交沙霉素 在 吡啶 作用下， 以98.2%的产率得到2',9-O-diacetyl josamycin
  参考文献：
  名称：

  Two novel N-glycoside 17, 18-unsaturated acid quinolin-3-ylmethyl ester josamycin derivatives

  摘要：

  A facile procedure was developed to synthesize novel N-glycoside josamycin derivatives by coupling 4'-amino-desmycarosyl josamycin derivatives with L-mycarose. A novel N-glycoside josamycin derivative 10a and a key intermediate 9a were designed and synthesized. And two rearranged compounds 9b and 10b were also got. (C) 2018 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2018.02.027

文献信息

• OKA, JSIXIKO;OSONO, TAKASI;NAGAKI, XIDEHO;MIESI, TOSIAKI;ABEH, SEDZO;SAJT+
  作者：OKA, JSIXIKO、OSONO, TAKASI、NAGAKI, XIDEHO、MIESI, TOSIAKI、ABEH, SEDZO、SAJT+

  DOI：——

  日期：——
• Two novel N-glycoside 17, 18-unsaturated acid quinolin-3-ylmethyl ester josamycin derivatives
  作者：Zhehui Zhao、Longlong Jin、Apeng Wang、Shuang Yang、Pingsheng Lei

  DOI：10.1016/j.tetlet.2018.02.027

  日期：2018.3

  A facile procedure was developed to synthesize novel N-glycoside josamycin derivatives by coupling 4'-amino-desmycarosyl josamycin derivatives with L-mycarose. A novel N-glycoside josamycin derivative 10a and a key intermediate 9a were designed and synthesized. And two rearranged compounds 9b and 10b were also got. (C) 2018 Published by Elsevier Ltd.