Ethyl-α-carbethoxy-4-dimethylamino-2-nitrocinnamate | 93836-01-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Ethyl-α-carbethoxy-4-dimethylamino-2-nitrocinnamate
• 英文别名: Ethyl-alpha-carbethoxy-4-dimethylamino-2-nitrocinnamate；diethyl 2-[[4-(dimethylamino)-2-nitrophenyl]methylidene]propanedioate
• CAS: 93836-01-2
• 化学式: C₁₆H₂₀N₂O₆
• 分子量: 336.345
• InChiKey: UYFRBFADISDAAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Ethyl-α-carbethoxy-4-dimethylamino-2-nitrocinnamate 生成 7-(Dimethylamino)-N-ethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
  参考文献：
  名称：

  BUCKLER, ROBERT T.;HATCH, ROBERT P.

  摘要：

  DOI：
• 作为产物：
  描述：

  4-二甲氨基-2-硝基苯甲醛 、 丙二酸二乙酯 生成 Ethyl-α-carbethoxy-4-dimethylamino-2-nitrocinnamate
  参考文献：
  名称：

  BUCKLER, ROBERT T.;HATCH, ROBERT P.

  摘要：

  DOI：

文献信息

• Detection of hydrogen peroxide with optical indicator chalcogen compounds
  申请人：Miles Inc.

  公开号：US05081044A1

  公开（公告）日：1992-01-14

  Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and a method for using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.

  对氧化剂（例如过氧化氢）敏感的光学指示剂硒化物或硫化物化合物，以及使用这种指示剂的方法。在氧化过程中，产生的中间体会自发地消除硒化物残基，形成一个提供光学信号（如荧光）的信号化合物。首选的荧光指示剂化合物是3-硒-3,4-二氢香豆素衍生物和3-硒-3,4-二氢-2-喹啉衍生物。这种指示剂化合物在过氧化氢的氧化作用下会产生高度荧光的产物，并且在分析系统中非常有用，该系统根据所测定的分析物生成过氧化氢。
• Optical indicator 3,4-dihydro-2-quinolones
  申请人：Miles Inc.

  公开号：US04778893A1

  公开（公告）日：1988-10-18

  Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.

  对氧化剂（例如过氧化氢）敏感的光学指示剂硒化物或硫化物化合物，以及制备和使用这种指示剂的方法。在氧化过程中，产生的中间体会自发地消除硒或硫残基，从而产生提供光学信号（如荧光）的信号化合物。优选的荧光指示剂化合物是3-硒-3,4-二氢香豆素衍生物和3-硒-3,4-二氢-2-喹啉衍生物。这种指示剂化合物在过氧化氢氧化时产生高度荧光产物，并且在分析系统中非常有用，该系统根据待测物产生过氧化氢。
• Optical indicator coumarins and methods for their preparation and use
  申请人：Miles Inc.

  公开号：US04996332A1

  公开（公告）日：1991-02-26

  Optical indicator chalcogen (selenide or sulfide) compounds responsive to oxidants, e.g., hydrogen peroxide, and methods for preparing and using such indicators. Upon oxidation the resulting intermediate undergoes spontaneous elimination of the chalcogen residue to yield a signal compound which provides an optical signal such as fluorescence. Preferred fluorogenic indicator compounds are 3-chalcogen-3,4-dihydrocoumarin derivatives and 3-chalcogen-3,4-dihydro-2-quinolone derivatives. Such indicator compounds provide highly fluorescent products upon oxidation by hydrogen peroxide and are useful in analytical systems which generate hydrogen peroxide in response to the analyte under determination.

  光学指示剂硫属化合物（硒化物或硫化物）对氧化剂（例如过氧化氢）具有响应性，并提供制备和使用这种指示剂的方法。在氧化作用下，产生的中间体会自发消除硫属残基，生成信号化合物，提供光学信号，如荧光。优选的荧光指示剂化合物是3-硫属-3,4-二氢香豆素衍生物和3-硫属-3,4-二氢-2-喹啉衍生物。这种指示剂化合物在过氧化氢氧化作用下提供高度荧光产物，并在分析系统中有用，该分析系统对待测物产生过氧化氢响应。
• Determination of hydrogen peroxide using fluorogenic dihydroquinolone
  申请人：Miles Inc.

  公开号：US04794079A1

  公开（公告）日：1988-12-27

  Fluorogenic indicator compounds responsive to the presence of hydrogen peroxide and methods and test compositions for determining hydrogen peroxide in a test sample. Preferred indicator compounds are 3,4-dihydrocoumarin derivatives and 3,4-dihydro-2-quinolone derivatives, especially those having a dialkylamino group at the 7-position. Such particularly preferred compounds are of the formula: ##STR1## wherein R.sup.1 is hydrogen, cyano, or --COOR.sup.6, --CONHR.sup.6 or --CON(R.sup.6).sub.2 where R.sup.6 is hydrogen, alkyl, alkenyl, or aryl; R.sup.3 and R.sup.4 are lower alkyl; and Y is .dbd.0 or .dbd.N--R.sup.5 where R.sup.5 is hydrogen or lower alkyl. The indicator compounds yield highly fluorescent products upon oxidation by hydrogen peroxide in the presence of a peroxidatively active substance and are useful in analytical systems which generate hydrogen peroxide in response to an analyte under determination in a test sample.

  对于存在过氧化氢的荧光指示剂化合物，以及用于确定测试样品中过氧化氢的方法和测试组成物。首选指示剂化合物是3,4-二氢香豆素衍生物和3,4-二氢-2-喹啉衍生物，特别是具有7-位置上的二烷基氨基基团的化合物。这样特别优选的化合物的公式为：##STR1##其中R.sup.1是氢，氰或--COOR.sup.6，--CONHR.sup.6或--CON（R.sup.6）.sub.2，其中R.sup.6是氢，烷基，烯烃基或芳基；R.sup.3和R.sup.4是较低的烷基；Y是.dbd.0或.dbd.N--R.sup.5，其中R.sup.5是氢或较低的烷基。在存在过氧化氢的过氧化物活性物质下，指示剂化合物通过氧化反应产生高度荧光的产物，并且在分析系统中非常有用，在该系统中，过氧化氢是根据测试样品中的分析物而产生的。
• Fluorogenic dihydroquinolone and dihydrocoumarin indicators for hydrogen
  申请人：Miles Laboratories, Inc.

  公开号：US04558130A1

  公开（公告）日：1985-12-10

  Fluorogenic indicator compounds responsive to the presence of hydrogen peroxide and methods and test compositions for determining hydrogen peroxide in a test sample. Preferred indicator compounds are 3,4-dihydrocoumarin derivatives and 3,4-dihydro-2-quinolone derivatives, especially those having a dialkylamino group at the 7-position. Such particularly preferred compounds are of the formula: ##STR1## wherein R.sup.1 is hydrogen, cyano, or --COOR.sup.6, --CONHR.sup.6 or --CON(R.sup.6).sub.2 where R.sup.6 is hydrogen, alkyl, alkenyl, or aryl; R.sup.3 and R.sup.4 are lower alkyl; and Y is .dbd.O or .dbd.N--R.sup.5 where R.sup.5 is hydrogen or lower alkyl. The indicator compounds yield highly fluorescent products upon oxidation by hydrogen peroxide in the presence of a peroxidatively active substance and are useful in analytical systems which generate hydrogen peroxide in response to an analyte under determination in a test sample.

  对过氧化氢敏感的荧光指示剂化合物及用于检测试样中过氧化氢的方法和测试组合物。首选的指示剂化合物是3,4-二氢香豆素衍生物和3,4-二氢-2-喹啉衍生物，特别是在7位具有二烷基氨基基团的化合物。这样特别优选的化合物的公式为：##STR1## 其中R.sup.1是氢，氰或--COOR.sup.6，--CONHR.sup.6或--CON(R.sup.6).sub.2，其中R.sup.6是氢，烷基，烯基或芳基；R.sup.3和R.sup.4是较低的烷基；Y是.dbd.O或.dbd.N--R.sup.5，其中R.sup.5是氢或较低的烷基。在过氧化氢存在的过氧化物活性物质存在下，指示剂化合物通过氧化反应生成高度荧光的产物，可用于在试样中检测分析物生成过氧化氢的分析系统。