11,17-Dimethylidenedispiro[2.4.28.73]heptadecane | 1332655-10-3

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 11,17-Dimethylidenedispiro[2.4.28.73]heptadecane
• 英文别名: 11,17-dimethylidenedispiro[2.4.28.73]heptadecane
• CAS: 1332655-10-3
• 化学式: C₁₉H₃₀
• 分子量: 258.447
• InChiKey: NMJSJTFBHQCIGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  二碘甲烷 、 11,17-Dimethylidenedispiro[2.4.28.73]heptadecane 、 4,12-Dimethylidenedispiro[2.5.29.63]heptadecane 、 12,17-Dimethylidenedispiro[2.5.29.63]heptadecane 在 三乙基铝 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到tetraspiro[2.0.2(4).4.2(11).0.2(14).5(3)]heneicosane
  参考文献：
  名称：

  A facile synthesis of spiro macrocarbocycles via the cycloalumination reaction of cyclic alkynes and alkadiynes

  摘要：

  Zirconium-catalyzed cycloalumination of cycloalkadiynes assisted by Et3Al, subsequent treatment of the in situ generated tricyclic dialuminum compounds with BrCH2OMe and finally cyclopropanation of the obtained dispiro cyclopropyl dimethylene macrocarbocycles with Et3Al-CH2I2 represents an efficient one-pot synthetic approach to prepare di- and tetraspiro cyclopropane-containing macrocarbocycles in very high yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.018
• 作为产物：
  描述：

  溴甲基甲基醚 、 1,7-环十三碳二炔 、 三乙基铝 在 二氯二茂锆 作用下， 以 正己烷 为溶剂， 生成 11,17-Dimethylidenedispiro[2.4.28.73]heptadecane 、 4,12-Dimethylidenedispiro[2.5.29.63]heptadecane 、 12,17-Dimethylidenedispiro[2.5.29.63]heptadecane
  参考文献：
  名称：

  A facile synthesis of spiro macrocarbocycles via the cycloalumination reaction of cyclic alkynes and alkadiynes

  摘要：

  Zirconium-catalyzed cycloalumination of cycloalkadiynes assisted by Et3Al, subsequent treatment of the in situ generated tricyclic dialuminum compounds with BrCH2OMe and finally cyclopropanation of the obtained dispiro cyclopropyl dimethylene macrocarbocycles with Et3Al-CH2I2 represents an efficient one-pot synthetic approach to prepare di- and tetraspiro cyclopropane-containing macrocarbocycles in very high yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.018

文献信息

• A facile synthesis of spiro macrocarbocycles via the cycloalumination reaction of cyclic alkynes and alkadiynes
  作者：Vladimir A. D’yakonov、Regina A. Tuktarova、Leonard M. Khalilov、Usein M. Dzhemilev

  DOI：10.1016/j.tetlet.2011.06.018

  日期：2011.9

  Zirconium-catalyzed cycloalumination of cycloalkadiynes assisted by Et3Al, subsequent treatment of the in situ generated tricyclic dialuminum compounds with BrCH2OMe and finally cyclopropanation of the obtained dispiro cyclopropyl dimethylene macrocarbocycles with Et3Al-CH2I2 represents an efficient one-pot synthetic approach to prepare di- and tetraspiro cyclopropane-containing macrocarbocycles in very high yields. (C) 2011 Elsevier Ltd. All rights reserved.