methyl 6-phenyl-2,4-cyclohexanedione-1-carboxylate | 80035-52-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 6-phenyl-2,4-cyclohexanedione-1-carboxylate
• 英文别名: 2,4-dioxo-6-phenyl-cyclohexanecarboxylic acid methyl ester；methyl 2,4-dioxo-6-phenylcyclohexanecarboxylate；2,4-Dioxo-6-phenyl-cyclohexancarbonsaeure-methylester；methyl 2,4-dioxo-6-phenylcyclohexane-1-carboxylate
• CAS: 80035-52-5
• 化学式: C₁₄H₁₄O₄
• mdl: MFCD00157169
• 分子量: 246.263
• InChiKey: AUZLBHFNOOBPJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2918300090

反应信息

• 作为反应物：
  描述：

  methyl 6-phenyl-2,4-cyclohexanedione-1-carboxylate 在 sodium ethanolate 作用下， 生成 2,4-dioxo-6-phenyl-cyclohexanecarboxylic acid
  参考文献：
  名称：

  Vorlaender, Justus Liebigs Annalen der Chemie, 1897, vol. 294, p. 284

  摘要：

  DOI：
• 作为产物：
  描述：

  Methyl cinnamate 、 乙酰乙酸甲酯 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 48.5h， 以61%的产率得到methyl 6-phenyl-2,4-cyclohexanedione-1-carboxylate
  参考文献：
  名称：

  （±）-Daurichromenic acid及其类似物的模块化简捷全合成

  摘要：

  从乙酰乙酸乙酯，巴豆酸乙酯和反式，反式法呢醛的四个步骤中完成了（±）-柔红铬酸的模块化，简明的全合成。还从乙酰乙酸乙酯或乙酰乙酸甲酯和一系列容易获得的α，β-不饱和酯和醛制备了具有有效抗HIV活性的该天然产物的一系列类似物。

  DOI：

  10.1021/jo049703f

文献信息

• Design, synthesis and biological evaluation of piperazino-enaminones as novel suppressants of pro-Inflammatory cytokines
  作者：Ola M. Ghoneim、Ashley Bill、Jyothi Dhuguru、Doreen E. Szollosi、Ivan O. Edafiogho

  DOI：10.1016/j.bmc.2018.06.003

  日期：2018.8

  encouraged further examination of its structural scaffold. Piperazino-enaminones were designed by incorporating n-arylpiperazine motif into the aromatic enaminone. Four possible modifications were explored systematically. Synthesis was accomplished by amination of the corresponding methyl/ethyl 2,4-dioxo-6-(substituted)cyclohexane-carboxylate.. Sixteen novel compounds were synthesized. Biological activity

  感染会触发促炎性细胞因子（TNF-α和IL-6）的释放。然而，过量生产会导致严重哮喘中出现的组织损伤。烯胺酮E121减少促炎细胞因子的能力在我们的实验室中鼓励了对其结构支架的进一步检查。哌嗪子酮-烯胺酮是通过结合n-芳基哌嗪基序变成芳族烯胺。系统地探讨了四个可能的修改。通过胺化相应的甲基/乙基2,4-二氧代-6-（取代）环己烷-羧酸酯来完成合成。合成了十六种新化合物。在用脂多糖刺激的J774巨噬细胞中测试了生物活性。通过ELISA测量细胞因子的释放。四种化合物以剂量依赖性方式显着抑制TNF-α和IL-6的释放。
• Method for producing 1,3-cyclohexanediol compound
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20030149293A1

  公开（公告）日：2003-08-07

  A method for producing 1,3-cyclohexanediol compounds, particularly a 1,3-cyclohexanediol compound rich in cis-form. A 1,3-cyclohexanediol compound is reduced with a boron hydride compound such as sodium borohydride. Selectivity of cis-form is improved when an alkali metal compound and/or an alkaline earth metal compound, particularly a halide, is allowed to exist in the reaction system.

  一种生产1,3-环己二醇化合物的方法，特别是富含顺式形式的1,3-环己二醇化合物。将1,3-环己二醇化合物与硼氢化合物（如硼氢化钠）还原。当允许碱金属化合物和/或碱土金属化合物，特别是卤化物存在于反应体系中时，顺式形式的选择性得到改善。
• Adhesive recording paper
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP1215644A2

  公开（公告）日：2002-06-19

  Disclosed is adhesive recording paper having an image-forming layer on one surface of a substrate, and having an adhesive layer and a stripping sheet in that order on the other surface thereof, wherein the ratio, Nmax/Nmin, of the maximum stripping force (Nmax) to the minimum stripping force (Nmin) needed for separating the stripping sheet from the adhesive layer at a service temperature is at most 3.5, preferably at most 2.0.

  本发明公开了一种胶粘记录纸，该记录纸在基材的一个表面上具有图像形成层，在基材的另一个表面上依次具有粘合剂层和剥离片，其中在使用温度下剥离片与粘合剂层分离所需的最大剥离力（Nmax）与最小剥离力（Nmin）之比 Nmax/Nmin 至多为 3.5，最好为 2.0。
• Photopolymerizable composition and recording material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1298490A2

  公开（公告）日：2003-04-02

  The present invention provides a photopolymerizable composition containing a polymerizable compound having an ethylenically unsaturated bond, a compound represented by the following general formula (I), and a radical generating agent capable of generating a radical by interacting with the compound represented by the following general formula (I). General Formula (I); In the general formula (I), R1, R2, and R3 each individually represent a hydrogen atom or a monovalent substituent; R4 represents at least one member selected from the group consisting of: a hydrogen atom, an aliphatic group, an aromatic group, and a heterocyclic group; Z1 represents a substituent necessary for allowing the compound represented by the general formula (I) to become a dye; and X- represents a group capable of forming an anion. The invention also provides a recording material in which a recording layer containing the photopolymerizable composition is provided on a support.

  本发明提供了一种可光聚合组合物，该组合物含有一种具有乙烯不饱和键的可聚合化合物、一种由以下通式(I)表示的化合物，以及一种能够通过与以下通式(I)表示的化合物相互作用而生成自由基的自由基生成剂。通式（I）； 在通式（I）中，R1、R2 和 R3 分别代表氢原子或一价取代基；R4 代表至少一个选自氢原子、脂肪族基团、芳香族基团和杂环基团的成员；Z1 代表使通式（I）所代表的化合物成为染料所必需的取代基；X- 代表能够形成阴离子的基团。本发明还提供了一种记录材料，在该记录材料中，含有可光聚合组合物的记录层被设置在支持物上。
• Method and apparatus for emulsification
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1510246A2

  公开（公告）日：2005-03-02

  An emulsification apparatus (10) is used in a production apparatus (12) of microcapsules. The emulsification apparatus (10) is constituted with an outer cylinder (24) and an inner cylinder (26) coaxially arranged in a superposed manner, the outer cylinder (24) is fixed, and the inner cylinder (26) is rotated at a circumferential speed ω. A liquid being processed is fed into the gap (25) between the outer cylinder (24) and the inner cylinder (26), thus a shear force is exerted to the liquid being processed, and the liquid being processed is thereby emulsified. The relation between the magnitude d (mm) of the gap (25), the viscosity η (mPa·sec) of the liquid being processed and the circumferential speed ω (m/sec) of the inner cylinder is such that the circumferential speed ω is controlled so that any one of the following relations may be satisfied: (1) When η ≤ 20, d ≤ 5/ω; (2) When 20 < η ≤ 50, d ≤ 10/ω; (3) When 50 < η ≤ 100, d ≤ 20/ω; (4) When 100 < η.

  一种乳化装置（10）用于微胶囊生产装置（12）。乳化装置（10）由同轴叠置的外筒（24）和内筒（26）构成，外筒（24）固定，内筒（26）以圆周速度ω旋转。被处理的液体被送入外圆筒 (24) 和内圆筒 (26) 之间的间隙 (25)，从而对被处理的液体施加剪切力，被处理的液体因此被乳化。间隙 (25) 的大小 d (毫米)、被处理液体的粘度 η (毫帕-秒) 和内圆筒的圆周速度 ω (米/秒) 之间的关系是这样的：圆周速度 ω 受控，以便满足下列关系中的任何一种： (1) 当 η ≤ 20 时，d ≤ 5/ω； (2) 当 20 < η ≤ 50 时，d ≤ 10/ω； (3) 当 50 < η ≤ 100 时，d ≤ 20/ω； (4) 当 100 < η 时。