2-phenyl-quinoline-4-carbonyl chloride ; hydrochloride | 7187-80-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-phenyl-quinoline-4-carbonyl chloride ; hydrochloride
• 英文别名: 2-Phenyl-chinolin-4-carbonylchlorid; Hydrochlorid；2-phenylquinoline-4-carboxylic acid chloride hydrochloride；2-Phenylquinoline-4-carbonyl chloride hydrochloride；2-phenylquinoline-4-carbonyl chloride;hydrochloride
• CAS: 7187-80-6
• 化学式: C₁₆H₁₀ClNO*ClH
• 分子量: 304.175
• InChiKey: MHADDXHZPKUFBY-UHFFFAOYSA-N

物化性质

• 熔点：
  120～123℃

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2-phenyl-quinoline-4-carbonyl chloride ; hydrochloride 以70%的产率得到
  参考文献：
  名称：

  IBRAHIM E.-S. A.; CHAABAN I.; EL-KHAWASS S. M., PHARMAZIE , 1977, 32, NO 3, 155-156

  摘要：

  DOI：

文献信息

• Pharmaceutical compositions containing naphthalene-and
  申请人：Rhone-Poulenc Sante

  公开号：US04684652A1

  公开（公告）日：1987-08-04

  Compounds of the formula: ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, phenyl, C.sub.3-6 cycloalkyl, phenylalkyl, cycloalkyl-alkyl or ##STR2## R.sub.3 and R.sub.4 being H or alkyl, R.sub.5 being alkenyl or alkynyl, and the sum of the carbon atoms in R.sub.3, R.sub.4 and R.sub.5 being 2 to 5, R.sub.2 is as defined for R.sub.1 and may also represent ##STR3## in which n is 0, 1, 2 or 3, it also being possible for R.sub.1 and R.sub.2 to form, with the nitrogen atom to which they are attached, a 5-, 6- or 7-membered heterocyclic radical which can contain another hetero-atom chosen from O and N and which can carry 1 or 2 substituents, Z is phenyl, pyridinyl, thienyl, thiazol-2-yl or substituted phenyl, X and R.sub.0 are H, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, nitro or CF.sub.3, A represents N or CH and E represents N or CH, some of which are known compounds, are therapeutically useful compounds useful in the treatment of anxiety states or of pulmonary, renal, circulatory or cardiovascular disorders.

  公式中的化合物：##STR1## 其中R.sub.1是C.sub.1-6烷基，苯基，C.sub.3-6环烷基，苯基烷基，环烷基-烷基或##STR2## R.sub.3和R.sub.4为H或烷基，R.sub.5为烯基或炔基，且R.sub.3，R.sub.4和R.sub.5中碳原子的总和为2至5，R.sub.2的定义与R.sub.1相同，也可以表示为##STR3## 其中n为0、1、2或3，R.sub.1和R.sub.2也可以与它们所连接的氮原子形成一个5-、6-或7-成员的杂环基团，该杂环基团可以含有另一个来自O和N的杂原子，并且可以携带1个或2个取代基，Z是苯基，吡啶基，噻吩基，噻唑-2-基或取代的苯基，X和R.sub.0是H，卤素，C.sub.1-3烷基，C.sub.1-3烷氧基，硝基或CF.sub.3，A代表N或CH，E代表N或CH，其中一些是已知的化合物，是有治疗焦虑状态或肺、肾、循环或心血管障碍的药用化合物。
• Pharmaceutical compositions containing azanaphthalene-carboxamide
  申请人：Rhone-Poulenc Sante

  公开号：US04711890A1

  公开（公告）日：1987-12-08

  Compounds of the formula: ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, phenyl, C.sub.3-6 cycloalkyl, phenylalkyl, cycloalkyl-alkyl or ##STR2## R.sub.3 and R.sub.4 being H or alkyl, R.sub.5 being alkenyl or alkynyl, and the sum of the carbon atoms in R.sub.3, R.sub.4 and R.sub.5 being 2 to 5, R.sub.2 is as defined for R.sub.1 and may also represent ##STR3## in which n is 0, 1, 2 or 3, it also being possible for R.sub.1 and R.sub.2 to form, with the nitrogen atom to which they are attached, a 5-, 6- or 7-membered heterocyclic radical which can contain another hetero-atom chosen from O and N and which can carry 1 or 2 substituents, Z is phenyl, pyridinyl, thienyl, thiazol-2-yl or substituted phenyl, X and R.sub.0 are H, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, nitro or CF.sub.3, A represents N or CH and E represents N or CH, some of which are known compounds, are therapeutically useful compounds useful in the treatment of anxiety states or of pulmonary, renal, circulatory or cardiovascular disorders.

  这个化合物的式子为：##STR1## 其中R.sub.1是C.sub.1-6烷基，苯基，C.sub.3-6环烷基，苯基烷基，环烷基-烷基或##STR2## R.sub.3和R.sub.4为H或烷基，R.sub.5为烯基或炔基，且R.sub.3，R.sub.4和R.sub.5中的碳原子总数为2到5，R.sub.2与R.sub.1的定义相同，也可以表示为##STR3## 其中n为0，1，2或3，R.sub.1和R.sub.2也可以与它们附着的氮原子形成一个5、6或7成员的杂环基团，该杂环基团可以含有另一个从O和N中选择的杂原子，并且可以携带1或2个取代基，Z为苯基，吡啶基，噻吩基，噻唑-2-基或取代苯基，X和R.sub.0为H，卤素，C.sub.1-3烷基，C.sub.1-3烷氧基，硝基或CF.sub.3，A代表N或CH，E代表N或CH，其中一些已知化合物，在治疗焦虑症或肺部，肾脏，循环或心血管疾病方面有用。
• DE252643
  申请人：——

  公开号：——

  公开（公告）日：——
• Rojahn; Schulten, Archiv der Pharmazie, 1926, p. 350
  作者：Rojahn、Schulten

  DOI：——

  日期：——
• US4684652A
  申请人：——

  公开号：US4684652A

  公开（公告）日：1987-08-04