1,5-diphenyl-1,2-dihydroimidazol-2-one | 16709-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,5-diphenyl-1,2-dihydroimidazol-2-one
• 英文别名: 1,5-Diphenylimidazolin-2-one；1,5-diphenyl-1,3-dihydro-imidazol-2-one；1.5-diphenyl-4-imidazolin-2-one；3,4-Diphenyl-Δ⁴-imidazolin-2-on；3,4-Diphenyl-4-imidazolin-2-on；3,4-diphenyl-1H-imidazol-2-one
• CAS: 16709-73-2
• 化学式: C₁₅H₁₂N₂O
• mdl: MFCD00690430
• 分子量: 236.273
• InChiKey: ATLYXUNYWWCGMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,5-diphenyl-1,2-dihydroimidazol-2-one 在 亚硝酰氯 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以60%的产率得到5-hydroxy-1,5-diphenylimidazoline-2,4-dione
  参考文献：
  名称：

  Nitrosochlorination reaction of substituted imidazolin-2-ones

  摘要：

  DOI：

  10.1007/bf00473483
• 作为产物：
  描述：

  苯基脲 在 rhodium(II) octanoate 、 三氟乙酸 作用下， 以 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 3.5h， 生成 1,5-diphenyl-1,2-dihydroimidazol-2-one
  参考文献：
  名称：

  N−H Insertion Reactions of Primary Ureas:  The Synthesis of Highly Substituted Imidazolones and Imidazoles from Diazocarbonyls

  摘要：

  Primary ureas have been used as substrates in rhodium-catalyzed N-H insertion reactions with an array of diazocarbonyls. The insertion reaction is efficient and gives excellent selectivity and yields. The products from the insertion reaction with diazoketones cyclize readily in the presence of acid to yield the corresponding imidazolones that can be further derivatized by N-alkylation with alkyl, allyl, and benzyl halides. Alternatively, the imidazolones were treated with phosphorus oxybromide to form the corresponding 2-bromoimidazoles that were further functionalized using a Suzuki coupling reaction.

  DOI：

  10.1021/jo048353u

文献信息

• Transannulation of 1-Sulfonyl-1,2,3-triazoles with Heterocumulenes
  作者：Stepan Chuprakov、Sen Wai Kwok、Valery V. Fokin

  DOI：10.1021/ja400350c

  日期：2013.3.27

  reactions with isocyanates and isothiocyanates, respectively. The proposed triazole-diazoimine equilibrium results in the formation of highly reactive azavinyl metal-carbenes, which react with heterocumulenes causing an apparent swap of 1,2,3-triazole core for another heterocycle.

  容易获得的 1-mesyl-1,2,3-三唑通过 Rh(II) 催化的异氰酸酯和异硫氰酸酯的脱氮反应分别有效地转化为各种咪唑酮和噻唑。所提出的三唑-重氮亚胺平衡导致高反应性氮杂乙烯基金属卡宾的形成，其与杂枯烯反应导致 1,2,3-三唑核明显交换为另一个杂环。
• N-Substituted .omega.-(2-oxo-4-imidazolin-1-yl) alcanoic acids and salts
  申请人：A. Nattermann & Cie GmbH

  公开号：US04349684A1

  公开（公告）日：1982-09-14

  The present invention refers to N-substituted .omega.-(2-oxo-4-imidazolin-1-yl) alcanoic acids as well as salts and esters thereof having the general formula I ##STR1## The compounds are useful, for example, as antiallergics, antiasthmatics, etc.

  本发明涉及N-取代的ω-(2-氧代-4-咪唑啉-1-基)脂肪酸及其盐和酯，其具有一般式I。这些化合物可用作抗过敏剂、抗哮喘剂等。
• 4-Amino-1,5-substituted-1,5-dihydro-imidazol-2-ones
  申请人：Jolidon Synese

  公开号：US20070213384A1

  公开（公告）日：2007-09-13

  The present invention relates to compounds of formula I wherein R 1 , R 2 , R 3 , and R 4 are as defined herein and to pharmaceutically acceptable acid addition salts thereof. Compounds of formula I or their tautomeric forms are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors. Such compounds are useful for the treatment of schizophrenia.

  本发明涉及以下式子的化合物： 其中R1、R2、R3和R4如本文所定义，并且其药学上可接受的酸盐。式I的化合物或其互变异构体是良好的甘氨酸转运体1（GlyT-1）抑制剂，并且对甘氨酸转运体2（GlyT-2）抑制剂具有良好的选择性。这种化合物对于治疗精神分裂症是有用的。
• N-substituted omega-(2-oxo-4-imidazolin-1-yl) alcanoic acids, salts and esters thereof, process for producing the same and these active agents containing pharmaceutical compounds
  申请人：A. Nattermann & Cie. GmbH

  公开号：EP0051829A1

  公开（公告）日：1982-05-19

  the present invention refers to new N-substituted ω-(2-oxo-4-imidazolin-1-yl) alcanoic acids as well as salts and esters thereof having the general formula I process for producing the same and these active agents containing pharmaceutical compounds.

  本发明是指新的 N-取代ω-(2-氧代-4-咪唑啉-1-基)辛酸及其具有通式 I 的盐和酯，以及这些含有药物活性剂的化合物的生产工艺。
• GOLOVKO V. V.; STATSENSKAYA A. I.; BASKAKOV YU. A.; PUTSYKIN YU. G., XIMIYA GETEROTSIKL. SOED.,(1986) N 10, 1339-1342
  作者：GOLOVKO V. V.、 STATSENSKAYA A. I.、 BASKAKOV YU. A.、 PUTSYKIN YU. G.

  DOI：——

  日期：——