5-methoxyindoleacetic acid | 1018591-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-methoxyindoleacetic acid
• 英文别名: 1H-Indole-2-acetic acid, 5-methoxy-；2-(5-methoxy-1H-indol-2-yl)acetic acid
• CAS: 1018591-50-8
• 化学式: C₁₁H₁₁NO₃
• 分子量: 205.213
• InChiKey: ITSUZTOXIGCANA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  62.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-methoxyindoleacetic acid 在 盐酸 、 吡啶硼烷 、 potassium carbonate 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 34.5h， 生成 ethyl 2-(1-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl) 5-methoxy-1H-indol-3-yl)acetate
  参考文献：
  名称：

  INDOLEACETIC ACID DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF

  摘要：

  本发明涉及一种吲哚乙酸衍生物及其制备方法和药用。具体地，本发明涉及一种通式(I)所示的化合物，其制备方法，包含该化合物的药物组合物，以及其作为咳嗽镇咳剂用于治疗咳嗽等疾病的用途。通式(I)中的每个取代基的定义与说明书中的定义相同。

  公开号：

  US20200095271A1

文献信息

• CHYMASE INHIBITORS
  申请人：Abeywardane Asitha

  公开号：US20120129863A1

  公开（公告）日：2012-05-24

  Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase. Also disclosed are pharmaceutical compositions, methods of using and making the same.

  本发明涉及小分子抑制剂，用于治疗涉及chymase的各种疾病和病状。同时还揭示了制药组合物、使用和制备方法。
• METHOD FOR EXTRACTING SUBSTANCE FROM FECES SAMPLE
  申请人：Keio University

  公开号：EP3348988A1

  公开（公告）日：2018-07-18

  An object of the present invention is to provide a more practical method for extracting substances from a fecal sample. More specifically, an object of the present invention is to provide a method for extracting substances from a fecal sample, the method being suitable for conducting analyses such as metabolomic analysis using mass spectrometry or nuclear magnetic resonance spectrometry, and metagenomic analysis using a next-generation sequencer. The present invention provides a method for extracting one or more substances from a fecal sample, comprising the following steps A to C: step A: a step of suspending the fecal sample in any one of the following solvents (a) to (g) to obtain a suspension: (a) a solvent comprising an aqueous solvent and a hydrophilic organic solvent; (b) a solvent comprising an aqueous solvent and a hydrophobic organic solvent; (c) a solvent comprising an aqueous solvent, a hydrophilic organic solvent and a hydrophobic organic solvent; (d) a solvent comprising a hydrophilic organic solvent; (e) a solvent comprising a hydrophobic organic solvent; (f) a solvent comprising a hydrophilic organic solvent and a hydrophobic organic solvent; and (g) a solvent consisting of water; step B: a step of separating a liquid layer comprising the solvent from the suspension; and step C: a step of removing proteins from the liquid layer and then obtaining the one or more substances.

  本发明的目的是提供一种更实用的从粪便样本中提取物质的方法。更具体地说，本发明的目的是提供一种从粪便样本中提取物质的方法，该方法适用于进行分析，例如使用质谱或核磁共振谱进行代谢组分析，以及使用新一代测序仪进行元基因组分析。本发明提供了一种从粪便样品中提取一种或多种物质的方法，包括以下步骤 A 至 C： 步骤 A：将粪便样品悬浮在以下溶剂（a）至（g）中的任一种溶剂中，以获得悬浮液：(a) 由水溶剂和亲水性有机溶剂组成的溶剂； (b) 由水溶剂和疏水性有机溶剂组成的溶剂； (c) 由水溶剂、亲水性有机溶剂和疏水性有机溶剂组成的溶剂；(d) 由亲水性有机溶剂组成的溶剂； (e) 由疏水性有机溶剂组成的溶剂； (f) 由亲水性有机溶剂和疏水性有机溶剂组成的溶剂；以及 (g) 由水组成的溶剂； 步骤 B：从悬浮液中分离出包含溶剂的液层的步骤；以及 步骤 C：从液层中去除蛋白质，然后获得一种或多种物质的步骤。
• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• ENGINEERED CELLS FOR PRODUCTION OF INDOLE-DERIVATIVES
  申请人：Danmarks Tekniske Universitet

  公开号：EP3938385A1

  公开（公告）日：2022-01-19
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.