管花苷B | 112516-04-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 中文名称: 管花苷B
• 英文名称: tubuloside B
• 英文别名: [(2R,3R,4S,5R,6R)-5-acetyloxy-6-[2-(3,4-dihydroxyphenyl)ethoxy]-3-hydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• CAS: 112516-04-8
• 化学式: C₃₁H₃₈O₁₆
• 分子量: 666.633
• InChiKey: HFJIGXAMJFDVFR-OMRKUVHCSA-N

物化性质

• 沸点：
  917.5±65.0 °C(Predicted)
• 密度：
  1.56±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  47
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  251
• 氢给体数：
  8
• 氢受体数：
  16

安全信息

• 储存条件：
  2-8℃，存于干燥密封处

制备方法与用途

生物活性

Tubuloside B 是从管花肉苁蓉茎中分离出的天然产物，能够抑制 TNFα 诱导的细胞凋亡，并具有抗氧化活性。

体外研究

用 Tubuloside B (1 mg/L、10 mg/L 或 100 mg/L) 处理 2 小时可减轻 TNFα 介导的细胞凋亡。

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 管花苷B 在 吡啶 作用下， 生成 isoacteoside peracetate
  参考文献：
  名称：

  Kobayashi, Hiromi; Oguchi, Hiroko; Takizawa, Nobuo, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 8, p. 3309 - 3314

  摘要：

  DOI：

文献信息

• COSMETIC COMPOSITION AND PREPARATION METHOD AND USE THEREOF
  申请人：Wang, Hailong

  公开号：EP2080506A1

  公开（公告）日：2009-07-22

  A skin-whitening, freckle-removing cosmetic composition, comprising an effective amount of extract from Cistanche deserticola and other useful adjuvants.

  一种美白祛斑化妆品组合物，包含有效量的肉苁蓉提取物和其他有用的佐剂。
• METHOD FOR PRODUCING EXTRACTS CONTAINING HYDROXYCINNAMIC COMPOUNDS FROM VEGETABLE WASTE PRODUCTS
  申请人：Hidroxicinamics, S.L.

  公开号：EP3398453A1

  公开（公告）日：2018-11-07

  The invention relates to a method for producing an extract containing hydroxycinnamic acids, characterized in that the method uses one or more vegetable waste products from the productions of vegetable food products as a raw material, and comprising the following steps: a) selecting at least one waste product from at least one specific vegetable; b) extracting the hydroxycinnamic acids present in the waste product; c) separating the main liquid phase containing the extracted compounds from the solids; d) clarifying the liquid phase produced in step c) and e) concentrating the clarified liquid phase. The invention also relates to the extract produced via this production method, and the formulation containing this extract.

  本发明涉及一种生产含羟基肉桂酸提取物的方法，其特征在于该方法使用一种或多种蔬菜食品生产过程中产生的蔬菜废品作为原料，包括以下步骤：a) 从至少一种特定蔬菜中选择至少一种废品；b) 提取废品中的羟基肉桂酸；c) 将含有提取化合物的主液相与固体分离；d) 澄清步骤 c) 中产生的液相；e) 浓缩澄清的液相。本发明还涉及通过这种生产方法生产的提取物以及含有这种提取物的配方。
• Method for producing extracts containing hydroxycinnamic compounds from vegetable waste products
  申请人：HIDROXICINAMICS, S.L.

  公开号：US10736862B2

  公开（公告）日：2020-08-11

  The invention relates to a method for producing an extract containing hydroxycinnamic acids, characterised in that the method uses one or more vegetable waste products from the production of vegetable food products as a raw material, and comprising the following steps: a) selecting at least one waste product from at least one specific vegetable; b) extracting the hydroxycinnamic acids present in the waste product; c) separating the main liquid phase containing the extracted compounds from the solids; d) clarifying the liquid phase produced in step c); and e) concentrating the clarified liquid phase. The invention also relates to the extract produced via this production method, and the formulations containing this extract.

  本发明涉及一种生产含羟基肉桂酸提取物的方法，其特征在于该方法使用一种或多种蔬菜食品生产过程中产生的蔬菜废品作为原料，并包括以下步骤：a) 从至少一种特定蔬菜中选择至少一种废品；b) 提取废品中的羟基肉桂酸；c) 将含有提取化合物的主液相与固体分离；d) 澄清步骤 c) 中产生的液相；以及 e) 浓缩澄清的液相。本发明还涉及通过这种生产方法生产的提取物以及含有这种提取物的配方。
• Composition comprising the extract of cistanche deserticola Y.C. MA showing enhancing activity of the neurite outgrowth and neurotrophic effects
  申请人：KYUNG HEE UNIVERSITY

  公开号：US20040219233A1

  公开（公告）日：2004-11-04

  The present invention relates to a composition comprising an extract of Cistanche deserticola Y. C. having nerve growth factor (NGF) similar activity for the prevention and treatment of neuronal degenerative brain disease. The extracts from Cistanche deserticola have potent neuronal cell protective activity by promoting neurite outgrowth and acting as a NGF therefore it can be used as the therapeutics or health food for treating and preventing neuro-degenerative brain diseases.

  本发明涉及一种组合物，该组合物包含以下物质的提取物 肉苁蓉 Y.C. 的提取物，该提取物具有类似神经生长因子（NGF）的活性，可用于预防和治疗神经元退行性脑病。 肉苁蓉提取物 肉苁蓉提取物 肉苁蓉提取物具有强大的神经元细胞保护活性，能促进神经元突起生长，起到神经生长因子的作用，因此可用作治疗和预防脑神经退行性疾病的药物或保健食品。
• Neuroprotective/neurostimulatory use of Cistanche extract
  申请人：Kim Sun-Yeou

  公开号：US20070178174A1

  公开（公告）日：2007-08-02

  The present invention relates to a composition comprising an extract of Cistanche deserticola Y. C. having nerve growth factor (NGF) similar activity for the prevention and treatment of neuronal degenerative brain disease. The extracts from Cistanche deserticola have potent neuronal cell protective activity by promoting neurite outgrowth and acting as a NGF therefore it can be used as the therapeutics or health food for treating and preventing neuro-degenerative brain diseases.