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2-(2-硝基-乙基)-呋喃 | 5462-90-8

中文名称
2-(2-硝基-乙基)-呋喃
中文别名
2-(2-硝基乙基)呋喃
英文名称
2-(2-nitroethyl)furan
英文别名
——
2-(2-硝基-乙基)-呋喃化学式
CAS
5462-90-8
化学式
C6H7NO3
mdl
MFCD06738228
分子量
141.126
InChiKey
CXQAMTGSMRTUTH-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1
  • 重原子数:
    10
  • 可旋转键数:
    2
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.333
  • 拓扑面积:
    59
  • 氢给体数:
    0
  • 氢受体数:
    3

安全信息

  • 海关编码:
    2932190090

SDS

SDS:e7184ce2f3ce232b27706df7170511e6
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上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Organocatalytic Biomimetic Reduction of Conjugated Nitroalkenes
    作者:Peter Schreiner、Zhiguo Zhang
    DOI:10.1055/s-2007-983805
    日期:2007.8
    A thiourea-catalyzed biomimetic reduction of conjugated nitroalkenes has been developed. Various aromatic and aliphatic conjugated nitroalkenes can be reduced to give the respective nitroalkanes with good yields under mild conditions. This protocol is not only practical, but may also provide insight into the mechanisms of redox transformations in biological systems.
    已经开发了一种硫脲催化的共轭硝基烯烃的仿生还原。各种芳香族和脂肪族共轭硝基烯烃可以在温和条件下以良好的产率还原得到相应的硝基烷烃。该协议不仅实用,而且还可以深入了解生物系统中氧化还原转化的机制。
  • Characterization of xenobiotic reductase A (XenA): study of active site residues, substrate spectrum and stability
    作者:Yanto Yanto、Hua-Hsiang Yu、Mélanie Hall、Andreas S. Bommarius
    DOI:10.1039/c0cc02354j
    日期:——
    Xenobiotic reductase A (XenA) has broad catalytic activity and reduces various α,β-unsaturated and nitro compounds with moderate to excellent stereoselectivity. Single mutants C25G and C25V are able to reduce nitrobenzene, a non-active substrate for the wild type, to produce aniline. Total turnover is dominated by chemical rather than thermal instability.
    外来化合物还原酶A(XenA)具有广泛的催化活性,能够以中等至优异的立体选择性还原各种α,β-不饱和及硝基化合物。单突变体C25G和C25V能够将野生型酶无法还原的非活性底物硝基苯还原为苯胺。总转化次数主要受化学稳定性而非热稳定性的影响。
  • Functional-Group Tolerance in Frustrated Lewis Pairs: Hydrogenation of Nitroolefins and Acrylates
    作者:Lutz Greb、Constantin-Gabriel Daniliuc、Klaus Bergander、Jan Paradies
    DOI:10.1002/anie.201210175
    日期:2013.5.27
    Weak Lewis acid for high nucleophilicity: Hydridoborate derived from B(2,6‐F2C6H3)3 shows significant hydride character. Solid‐state and solution structure analysis revealed a dihydrogen‐bonded aggregate. The new frustrated Lewis pair was applied in the hydrogenation of nitroolefins and acrylates (see scheme; EWG=electron‐withdrawing group). The decreased Lewis acidity provides higher reactivity and
    路易斯酸,具有高亲核性:衍生自B(2,6-F 2 C 6 H 3)3的氢硼酸盐显示出显着的氢化物特征。固态和溶液结构分析表明,存在氢键结合的聚集体。新的受阻的路易斯对用于硝基烯烃和丙烯酸酯的氢化反应(参见方案; EWG =吸电子基团)。降低的路易斯酸度可提供更高的反应性和官能团耐受性。
  • Conjugate Addition of Nitro-Derivatives to α,β-Unsaturated Carbonyl Compounds on Basic Alumina
    作者:Goffredo Rosini、Emanuela Marotta、Roberto Ballini、Marino Petrini
    DOI:10.1055/s-1986-31630
    日期:——
    Conjugate addition of nitroalkanes to α,β-unsaturated carbonyl compounds occurs in the presence of basic alumina without a solvent. Yields are fair to good also with substrates which are acid or base sensitive.
    无溶剂条件下,在碱性氧化铝存在下,硝基烷烃与α,β-不饱和羰基化合物的共轭加成反应发生。即使是酸或碱敏感的底物,产率也相当不错。
  • Asymmetric Organocatalytic Sequential Reaction of Structurally Complex Cyclic Hemiacetals and Functionalized Nitro-olefins To Synthesize Diverse Heterocycles
    作者:Jun-Ping Pei、Ying-Han Chen、Yan-Kai Liu
    DOI:10.1021/acs.orglett.8b01386
    日期:2018.6.15
    Structurally complex cyclic hemiacetals bearing a racemic tetrasubstituted stereocenter have been prepared in a concise manner and were successfully used in an organocatalytic enantioselective sequence to react with functionalized nitro-olefins, providing bicyclic acetal-containing compounds as two separable epimers with excellent stereoselectivity. The reaction showed broad substrate scope, with respect
    以简洁的方式制备了具有外消旋四取代的立体中心的结构复杂的环状半缩醛,并将其成功地用于有机催化对映选择性序列中,与官能化的硝基烯烃反应,从而提供了含双环缩醛的化合物,作为两种可分离的差向异构体,具有出色的立体选择性。该反应显示出相对于起始半缩醛而言较宽的底物范围。而且,该方案允许将产物合成转化为具有实质性结构多样性和广泛功能性的各种有趣的杂环化合物
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