2-(3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid
• 英文别名: 2-(1H-imidazo[4,5-b]pyridin-2-yl)benzoic acid
• 化学式: C₁₃H₉N₃O₂
• mdl: MFCD11502939
• 分子量: 239.233
• InChiKey: DUQFRZOCKBOWLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻羧基苯甲醛 在 sodium disulfite 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 2-(3H-imidazo[4,5-b]pyridin-2-yl)benzoic acid
  参考文献：
  名称：

  Synthesis and potent cytotoxicity of some novel imidazopyridine derivatives against MCF-7 human breast adenocarcinoma cell line

  摘要：

  A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and their precursors were synthesized. Their in vitro cytotoxicity against MCF-7 human breast adenocarcinoma cell line has been investigated, and some of the tested compounds have shown high cytotoxic activity against MCF-7 cells. N-Hydroxy-4-(3H-imidazo[4,5-b]pyridin-2-yl)benzenecarboximidamide was the most active compound with IC50 equal to 0.082 mu M, which is an activity almost as high as that of a commonly used anticancer drugs docetaxel and imatinib mesylate.

  DOI：

  10.1007/s10593-015-1765-7

文献信息

• US4696931A
  申请人：——

  公开号：US4696931A

  公开（公告）日：1987-09-29
• Synthesis and potent cytotoxicity of some novel imidazopyridine derivatives against MCF-7 human breast adenocarcinoma cell line
  作者：Mustafa Orhan Püsküllü、Cigdem Karaaslan、Filiz Bakar、Hakan Göker

  DOI：10.1007/s10593-015-1765-7

  日期：2015.8

  A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and their precursors were synthesized. Their in vitro cytotoxicity against MCF-7 human breast adenocarcinoma cell line has been investigated, and some of the tested compounds have shown high cytotoxic activity against MCF-7 cells. N-Hydroxy-4-(3H-imidazo[4,5-b]pyridin-2-yl)benzenecarboximidamide was the most active compound with IC50 equal to 0.082 mu M, which is an activity almost as high as that of a commonly used anticancer drugs docetaxel and imatinib mesylate.