D-tagatose 1-phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-tagatose 1-phosphate
• 英文别名: [(3S,4S,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl] dihydrogen phosphate
• 化学式: C₆H₁₃O₉P
• 分子量: 260.138
• InChiKey: ZKLLSNQJRLJIGT-PQLUHFTBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  165
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  D-tagatose 1-phosphate 在 silver nitrate 、 Escherichia coli acid phosphatase 、 水 作用下， 以 水 为溶剂， 以495 mg的产率得到D-塔格糖
  参考文献：
  名称：

  酶的简便酶法合成

  摘要：

  缺乏有效的制备方法阻碍了稀有酮糖的研究。本文描述了一种方便，高效且经济高效的酮糖合成平台。该方法可从常见且廉价的起始原料中制备难以获得的酮戊糖和酮己糖，且产率高，纯度高，且无需繁琐的异构体分离步骤。

  DOI：

  10.1002/anie.201505714
• 作为产物：
  描述：

  口服葡萄糖 在 Human fructokinase 、 Thermotoga maritima MSB₈ d-galactose isomerase 、 magnesium 、 锰 、 5’-三磷酸腺苷 作用下， 生成 D-tagatose 1-phosphate
  参考文献：
  名称：

  酶的简便酶法合成

  摘要：

  缺乏有效的制备方法阻碍了稀有酮糖的研究。本文描述了一种方便，高效且经济高效的酮糖合成平台。该方法可从常见且廉价的起始原料中制备难以获得的酮戊糖和酮己糖，且产率高，纯度高，且无需繁琐的异构体分离步骤。

  DOI：

  10.1002/anie.201505714

文献信息

• APPLICATION OF D-PSICOSE TO SUPPRESSION OF ABNORMAL CIRCADIAN INCREASE IN BLOOD GLUCOSE LEVEL
  申请人：National University Corporation Kagawa University

  公开号：EP1864669A1

  公开（公告）日：2007-12-12

  A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.

  本研究提供了一种 D-车前子糖的新型用途（用于抑制血糖水平在一天内的异常升高）。一种含有 D-车前子糖作为活性成分并用于抑制血浆葡萄糖浓度日内异常升高的组合物。该组合物是一种与 D-车前子糖和/或其衍生物混合的组合物。该组合物的形式选自甜味剂、调味料、食品添加剂、食品材料、食品和饮料产品、保健食品和饮料产品、医药产品和饲料，并与作为活性成分的 D-车前子糖和/或其衍生物混合，用于预防和治疗需要挽救胰岛素不足的疾病、改善胰岛素敏感性和改善高血糖症，和/或通过抑制血浆葡萄糖浓度日内异常升高可改善症状或通过抑制可预防发病的疾病，如糖尿病、隐性糖尿病状态、肥胖症、高血糖症和/或动脉硬化。一种使用D-胰高血糖素抑制血浆葡萄糖浓度日内异常升高的方法，包括在给定时间给予D-胰高血糖素以抑制全天血浆葡萄糖浓度的异常升高。
• POLYMER ELECTROLYTE COMPOSITION AND POLYMER ELECTROLYTE MEMBRANE, MEMBRANE-ELECTROLYTE ASSEMBLY, AND SOLID POLYMER FUEL CELL USING SAME
  申请人：Toray Industries, Inc.

  公开号：EP3131145A1

  公开（公告）日：2017-02-15

  [Problem] To provide: a polymer electrolyte composition that has excellent chemical stability that makes it possible to withstand a strong oxidizing atmosphere during fuel cell operation, that makes it possible to achieve excellent protonic conductivity under low humidity conditions, excellent mechanical strength, and excellent physical durability, and that is highly practical; and a polymer electrolyte membrane, a membrane-electrode assembly, and a solid polymer fuel cell that use the polymer electrolyte composition. [Solution] A polymer electrolyte composition that comprises at least an ionic group-containing polymer (A), an organic phosphorus-based additive (C), and a nitrogen-containing heteroaromatic ring system additive (D) and that is characterized by the nitrogen-containing heteroaromatic ring system additive (D) comprising at least three nitrogen-containing heteroaromatic rings within a molecule thereof. In addition, the polymer electrolyte membrane, the catalyst layer-equipped electrolyte membrane, the membrane-electrode assembly, and the solid polymer fuel cell of the present invention are characterized by being configured using the polymer electrolyte composition.

  问题 提供一种聚合物电解质组合物，该组合物具有优异的化学稳定性，能够在燃料电池运行期间耐受强氧化性气氛，能够在低湿度条件下实现优异的质子电导率，具有优异的机械强度和优异的物理耐久性，并且具有很高的实用性；以及一种使用该聚合物电解质组合物的聚合物电解质膜、膜电极组件和固体聚合物燃料电池。[解决方案]一种聚合物电解质组合物，它至少包含一种含离子基团的聚合物（A）、一种有机磷基添加剂（C）和一种含氮杂芳香族环系添加剂（D），其特征在于含氮杂芳香族环系添加剂（D）在其分子内至少包含三个含氮杂芳香族环。此外，本发明的聚合物电解质膜、配备催化剂层的电解质膜、膜电极组件和固体聚合物燃料电池的特征在于使用聚合物电解质组合物进行配置。
• [EN] AUTONOMOUS INDUCIBLE DIRECTED EVOLUTION OF COMPLEX PATHWAYS<br/>[FR] ÉVOLUTION DIRIGÉE INDUCTIBLE AUTONOME DE VOIES COMPLEXES
  申请人：UNIV NORTH CAROLINA STATE

  公开号：WO2021067831A1

  公开（公告）日：2021-04-08

  A method for directed evolution in a microbe, the method comprising: introducing into a first host cell a propagation deficient phage genome and a vector comprising a target gene sequence to be mutated and a phage propagation component responsive to induce lysis of the first host cell and to provide for propagation of the phage genome; exposing the first host cell to a mutagenesis agent; inducing lysis of the first host cell and phage propagation to produce a lysate comprising phage particles comprising the target gene sequence; and infecting a second host cell with the lysate. Systems and kits for practicing the method are also disclosed.