allyl 3-O(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-2-O-6-O-(4-methoxyphenol)-α-D-glycopyranoside | 1343988-82-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: allyl 3-O(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-2-O-6-O-(4-methoxyphenol)-α-D-glycopyranoside
• 英文别名: allyl 3-O-(2,3,4,6-tetra-O-benzyl-beta-D-glucopyranosyl)-2-O-benzyl-6-O-(4-methoxyphenyl)-alpha-D-glucopyranoside；(2R,3R,4S,5R,6S)-2-[(4-methoxyphenoxy)methyl]-5-phenylmethoxy-6-prop-2-enoxy-4-[(2S,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxyoxan-3-ol
• CAS: 1343988-82-8
• 化学式: C₅₇H₆₂O₁₂
• 分子量: 939.112
• InChiKey: YVKCSMRWSRKPAZ-UMKDCRKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  69
• 可旋转键数：
  25
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  122
• 氢给体数：
  1
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  2-pivaloyl-3,4,6-tri-O-benzyl-β-D-glucopyranosyl trichloroacetimidate 、 allyl 3-O(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-2-O-6-O-(4-methoxyphenol)-α-D-glycopyranoside 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 1.17h， 以86%的产率得到
  参考文献：
  名称：

  [EN] SYNTHETIC OLIGOSACCHARIDES FOR MORAXELLA VACCINE
  [FR] OLIGOSACCHARIDES SYNTHÉTIQUES POUR VACCINS CONTRE MORAXELLA

  摘要：

  公开号：

  WO2011137181A8
• 作为产物：
  描述：

  2-PROPENYL4,6-O-BENZYLIDENE-Α-D-GLUCOPYRANOSIDE2-丙烯基4,6-O-亚苄基-Α-D-吡喃葡萄糖苷 在 吡啶 、 甲醇 、 sodium methylate 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 23.34h， 生成 allyl 3-O(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-2-O-6-O-(4-methoxyphenol)-α-D-glycopyranoside
  参考文献：
  名称：

  [EN] SYNTHETIC OLIGOSACCHARIDES FOR MORAXELLA VACCINE
  [FR] OLIGOSACCHARIDES SYNTHÉTIQUES POUR VACCINS CONTRE MORAXELLA

  摘要：

  公开号：

  WO2011137181A8

文献信息

• Synthetic Oligosaccharides for Moraxella Vaccine
  申请人：CAMPBELL A. Stewart

  公开号：US20140148592A1

  公开（公告）日：2014-05-29

  The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.

  本发明提供了基于合成Moraxella catarrhalis脂多糖（LOS）的寡糖和共轭物，其中包含各种M. catarrhalis血清型特异性寡糖抗原或对应于给定血清型内的三种主要血清型和/或成员的各种核心M. catarrhalis寡糖结构或基序。这些寡糖可以通过化学组装方法合成，该方法依赖于有限数量的单糖和二糖构建块。本发明还提供了基于M. catarrhalis LOS的免疫原和免疫保护组合物以及由此产生的抗体，用于诊断、治疗和预防由M. catarrhalis引起的感染。
• Synthetic oligosaccharides for Moraxella vaccine
  申请人：Campbell A. Stewart

  公开号：US08716469B2

  公开（公告）日：2014-05-06

  The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immuno-protective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.

  本发明提供了基于合成Moraxella catarrhalis脂寡糖（LOS）的寡糖和结合物，其中包含各种M. catarrhalis血清型特异性寡糖抗原或对应于给定血清型中的三个主要血清型之一或多个成员的各种核心M. catarrhalis寡糖结构或基序。这些寡糖可以通过依赖有限数量的单糖和双糖构建块的化学组装方法合成。本发明还提供了基于M. catarrhalis LOS的免疫原性和免疫保护性组合物以及由此派生的抗体，用于诊断、治疗和预防由M. catarrhalis引起的感染。
• SYNTHETIC OLIGOSACCHARIDES FOR MORAXELLA VACCINE
  申请人：VISTERRA, INC.

  公开号：US20160375120A1

  公开（公告）日：2016-12-29

  The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.
• US8716469B2
  申请人：——

  公开号：US8716469B2

  公开（公告）日：2014-05-06
• US9447133B2
  申请人：——

  公开号：US9447133B2

  公开（公告）日：2016-09-20