1-(2-噻吩氧基)-2,3-环氧丙烷 | 76142-57-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(2-噻吩氧基)-2,3-环氧丙烷
• 英文名称: 1-(2-thienyloxy)-2,3-epoxypropane
• 英文别名: 2-(Thiophen-2-yloxymethyl)oxirane
• CAS: 76142-57-9
• 化学式: C₇H₈O₂S
• 分子量: 156.205
• InChiKey: FHFOCJGOLRPOGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  50
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-噻吩氧基)-2,3-环氧丙烷 、 4-甲氧基苯酚 在 四丁基氟化铵 、 silver nitrate 作用下， 以 异丙醇 为溶剂， 反应 6.5h， 以77%的产率得到
  参考文献：
  名称：

  Silver nanoparticle-catalysed phenolysis of epoxides under neutral conditions: Scope and limitations of metal nanoparticles and applications towards drug synthesis

  摘要：

  Chemo- and regio-selective epoxide phenolysis is reported for the first time under neutral condition catalysed by silver nanoparticles. Other metal nanoparticles (e.g., Au, Pd, Cu, In, and Ru) are less effective. The choice of solvent is critical with 2-propanol being the best followed by DEF. Amongst various stabilisers used (surfactants, PEGs, tetra-allcylammonium halides) the tetra-alkylammonium halides are found to be the most effective (TBAF > TBAB > TBACl > TBAI). The role of the silver nanoparticles is envisaged as synchronous mode epoxide-phenol dual activation via a cooperative network of coordination, anion-it interaction, and hydrogen bond. The silver nanoparticles are recovered and reused for five consecutive times. The reaction has been used for the synthesis of propranolol and naftopidil as a few representative cardiovascular drugs. (C) 2014 Published by Elsevier B.V.

  DOI：

  10.1016/j.molcata.2014.05.011
• 作为产物：
  描述：

  1-(2-thienyloxy)-2,3-O-isopropilydene propane 在 sodium hydroxide 、 溶剂黄146 、 对甲苯磺酰氯 作用下， 反应 24.75h， 生成 1-(2-噻吩氧基)-2,3-环氧丙烷
  参考文献：
  名称：

  Conde; Corral; Lissavetzky, European Journal of Medicinal Chemistry, 1983, vol. 18, # 2, p. 151 - 154

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCING FINE ORGANOMETALLIC PARTICLES AND CATALYST FOR POLYMERIZATION
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP0990657A1

  公开（公告）日：2000-04-05

  The present invention provides: a production process for a polyalkylene oxide with fast polymerization reaction rate and good production efficiency; a catalyst for polymerization and a dispersion thereof which are effective for the above production process for a polymer such as polyalkylene oxide; and an organometallic fine particle and a production process therefor, which particle is, for example, useful as the above catalyst for polymerization. In a means therefor, a material such as an aliphatic polyol is reacted upon an organometallic compound in a micelle as the reaction field, thus preparing a hyperfine particle, which is used as a catalyst for polymerization of ionic-polymerizable monomers mainly including a cyclic ether.

  本发明提供了：一种聚合反应速度快、生产效率高的聚环氧烷的生产工艺；一种聚合催化剂及其分散液，它对上述聚环氧烷等聚合物的生产工艺是有效的；以及一种有机金属微粒及其生产工艺，该微粒例如可用作上述聚合催化剂。在其方法中，脂肪族多元醇等材料与有机金属化合物在作为反应场的胶束中发生反应，从而制备出超细粒子，该粒子用作主要包括环醚在内的可离子聚合单体的聚合催化剂。
• Flame retarded epoxy resin composition
  申请人：——

  公开号：US20020082322A1

  公开（公告）日：2002-06-27

  The present invention relates to a flame retarded epoxy resin composition, which is characterized by that said flame retarded epoxy resin composition comprising: (A) at least one type of epoxy resin; (B) a phosphorus-and-nitrogen-containing heterocyclic compound, said compound having a moiety which can react with the epoxy group of the epoxy resin, usedful as a hardening agent, and having a structure as shown by formula (I): 1 wherein m is an integer of from 0 to 2, n is an integer of from 3 to 7, but at least one m is not 2. The epoxy resin composition consisting of the above components (A) and (B) has improved flame retarded property and thus is suitably used as the flame retarded material required for the parts of composite material, laminated plates, printed circuit boards, electronic products, electrical products, and the like. According to the range of applications, the composition can be selectively added with additives such as a hardening agent, which does not contain phosphorus, a hardening promoter, a solvent, and the like.

  本发明涉及一种阻燃环氧树脂组合物，其特征在于所述阻燃环氧树脂组合物包括 (A) 至少一种环氧树脂； (B) 含磷氮杂环化合物，所述化合物具有可与环氧树脂的环氧基反应的分子，用作硬化剂，其结构如式（I）所示： 1 其中 m 是 0 至 2 的整数，n 是 3 至 7 的整数，但至少有一个 m 不是 2。 由上述成分（A）和（B）组成的环氧树脂组合物具有更好的阻燃性能，因此适合用作复合材料、层压板、印刷电路板、电子产品、电气产品等部件所需的阻燃材料。根据应用范围，该组合物可以有选择性地添加添加剂，如不含磷的硬化剂、硬化剂促进剂、溶剂等。
• CONDE, S.;CORRAL, C.;LISSAVETZKY, J.;DARIAS, V.;MARTIN, D., EUR. J. MED. CHEM., 1983, 18, N 2, 151-154
  作者：CONDE, S.、CORRAL, C.、LISSAVETZKY, J.、DARIAS, V.、MARTIN, D.

  DOI：——

  日期：——
• PROCEDE DE PREPARATION DE DERIVES DE 2-THIENYLETHYLAMINE
  申请人：SANOFI-SYNTHELABO

  公开号：EP0971915B1

  公开（公告）日：2003-05-14
• US6084059A
  申请人：——

  公开号：US6084059A

  公开（公告）日：2000-07-04