3,3,4,4,5,5,6,6,7,7,8,8-dodecafluorooctanol | 800382-22-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3,4,4,5,5,6,6,7,7,8,8-dodecafluorooctanol
• 英文别名: 3,3,4,4,5,5,6,6,7,7,8,8-Dodecafluorooctan-1-ol
• CAS: 800382-22-3
• 化学式: C₈H₆F₁₂O
• 分子量: 346.116
• InChiKey: YZZOCUXLHPDRAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  3,3,4,4,5,5,6,6,7,7,8,8-dodecafluorooctanol 、 碳酸二甲酯 在 sodium methylate 作用下， 反应 10.0h， 以99%的产率得到
  参考文献：
  名称：

  一种含氟碳酸酯的合成方法

  摘要：

  本发明公开了一种含氟碳酸酯的合成方法，将氟醇和碳酸二甲酯按摩尔比1：(0.25‑5.0)反应，以碱作为催化剂，反应设备为反应精馏塔，反应温度为60‑120℃，经过反应精馏后依次得到甲醇，碳酸二甲酯和含氟碳酸酯，含氟碳酸酯经过分子筛干燥后得到最终产品。本发明采用反应精馏工艺，反应的过程中及时移除产物甲醇，提高了反应物氟醚的转化率，最终产品也可以通过反应精馏设备蒸出，不需要后续的精馏处理，只需要干燥处理，降低了设备成本和生产。

  公开号：

  CN109232256A
• 作为产物：
  描述：

  8-chloro-3,3,4,4,5,5,6,6,7,7,8,8-dodecafluorooctan-1-ol 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 3,3,4,4,5,5,6,6,7,7,8,8-dodecafluorooctanol
  参考文献：
  名称：

  Mesomorphic Properties of Some Liquid Crystals with Semifluorocarbon Chains

  摘要：

  Three series of chiral compounds with semifluorocarbon chains have been synthesized. These compounds were characterized by infra-red spectra (IR), H-1 nuclear magnetic resonance (H-1 NMR), F-19 nuclear magnetic resonance (F-19 NMR), mass spectra (MS), and elemental analysis. Their phase-transition behavior was investigated by differential scanning calorimeter (DSC) and polarizing optical microscopy. To a certain compound, when the terminal hydrogen atom in the semi-fluoroalkyl chain was substituted by a chlorine atom, both the clearing point and the melting point were increased and the thermal stability of the SmC phase was enhanced. Moreover, with the introduction of a triple bond in the core, both the melting point and the clearing point were increased.

  DOI：

  10.1080/15421400701613458

文献信息

• COMPOSITION FOR ABSORPTION REFRIGERATOR
  申请人：SANYO ELECTRIC CO., LTD.

  公开号：EP0048281A1

  公开（公告）日：1982-03-31

  A composition for an absorption refrigerator, which contains at least one fluorinated alcohol refrigerant containing 2 to 10 carbon atoms, is liquid at ordinary temperature, and becomes volatile upon heating under ordinary or reduced pressure, and at least one absorbent having a higher boiling point than said refrigerant at ordinary pressure and being capable of absorbing said refrigerant; and an absorption-refrigerating system using said composition.

  一种用于吸收式制冷机的组合物，它包含至少一种含 2 至 10 个碳原子的氟化醇制冷剂，在常温下为液态，在常压或减压下加热时变为挥发性，以及至少一种吸收剂，在常压下其沸点高于所述制冷剂，并能吸收所述制冷剂；以及一种使用所述组合物的吸收式制冷系统。
• Color-codes and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
  申请人：CeloNova Biosciences, Inc.

  公开号：EP2545906A1

  公开（公告）日：2013-01-16

  Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poiy[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance use identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.

  提供了用于治疗和/或诊断程序的聚合物微粒。这种微粒包括泊[双（三氟乙氧基）磷苯]和/或其衍生物，这些衍生物可存在于整个微粒中或微粒的外涂层中。颗粒还可以包括一个具有由丙烯酸聚合物形成的水凝胶的核心。可向用户提供特定尺寸的此类微粒，以便在特定临床用途中选择性地栓塞特定尺寸的血管或使用活性成分制剂进行局部治疗。本发明的微粒还可进一步以彩色编码微球或纳米球的形式提供，以便在使用中随时识别微粒的大小。这种彩色编码的微球或纳米球可进一步提供在类似彩色编码的输送或容纳装置中，以加强使用识别，并提供使用特定所需尺寸的微球或纳米球的视觉确认。
• Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
  申请人：Varian Medical Systems, Inc.

  公开号：US10973770B2

  公开（公告）日：2021-04-13

  Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy)phosphazene and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be provided to a user in specific selected sizes to allow for selective embolization of certain sized blood vessels or localized treatment with an active component agent in specific clinical uses. Particles of the present invention may further be provided as color-coded microspheres or nanospheres to allow ready identification of the sized particles in use. Such color-coded microspheres or nanospheres may further be provided in like color-coded delivery or containment devices to enhance user identification and provide visual confirmation of the use of a specifically desired size of microspheres or nanospheres.

  聚合物微粒可用于治疗和/或诊断程序。颗粒包括聚[双(三氟乙氧基)磷苯和/或其衍生物，可存在于整个颗粒或颗粒的外涂层中。颗粒还可以包括一个具有由丙烯酸聚合物形成的水凝胶的核心。可向用户提供特定尺寸的此类微粒，以便在特定临床用途中选择性地栓塞特定尺寸的血管或使用活性成分制剂进行局部治疗。本发明的微粒还可进一步以彩色编码微球或纳米球的形式提供，以便在使用中随时识别微粒的大小。这种彩色编码的微球或纳米球可进一步提供在类似彩色编码的输送或容纳装置中，以加强用户识别，并提供使用特定所需尺寸的微球或纳米球的视觉确认。
• Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
  申请人：Varian Medical Systems, Inc.

  公开号：US11052050B2

  公开（公告）日：2021-07-06

  Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Barium sulfate may also be provided to the core of the particles as a coating or absorbed within the core of the particles. The particles can be used to minimize blood flow to mammalian tissues by occluding at least a portion of a blood vessel of the mammal, or to deliver an active agent to a localized area within a body of a mammal by contacting a localized area with at least one of the particles. Farther, the particles are useful in sustained release formulations including active agent(s) for oral administration, as tracer particles for injection into the bloodstream of a mammal or for use in enhanced ultrasound imaging. The particles may include agents for increasing density for achieving useful buoyancy levels in suspension.

  所提供的微粒可用于治疗和/或诊断程序。微粒包括聚[双（三氟乙氧基）磷苯]和/或其衍生物，这些衍生物可存在于整个微粒或微粒的外涂层中。颗粒还可以包括一个具有由丙烯酸聚合物形成的水凝胶的核心。硫酸钡也可以作为涂层提供给颗粒核心，或被吸收在颗粒核心内。这些微粒可用于通过堵塞哺乳动物血管的至少一部分来减少流向哺乳动物组织的血流量，或通过将至少一种微粒与哺乳动物体内的局部区域接触来将活性剂输送到局部区域。此外，微粒还可用于包括口服活性剂在内的缓释制剂，或作为示踪微粒注射到哺乳动物的血液中，或用于增强超声波成像。颗粒可包括增加密度的制剂，以达到悬浮液中有用的浮力水平。
• LOADABLE POLYPHOSPHAZENE-COMPRISING PARTICLES FOR THERAPEUTIC AND/OR DIAGNOSTIC APPLICATIONS AND METHODS OF PREPARING AND USING THE SAME
  申请人：CeloNova BioSciences Germany GmbH

  公开号：EP1804773B1

  公开（公告）日：2011-03-30