申请人：Leban Johann
公开号：US20070037753A1
公开（公告）日：2007-02-15
The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof,
wherein
Y is —NR
a
R
b
, —NR
c
C═ONR
a
R
b,
—NR
c
C═SNR
a
R
b
, —NR
c
C═NR
d
N
a
R
b
, heterocycle, —C═ONR
a
R
b
, heterocycle, or aryl; n is 0 to 8; m is 0, or 1; r is 0 to 3; t is 0 to 3; X is O or N;
Z is CH
2
, C═O, C═S or a single bond;
Z
1
is CO—R
2
, CS—R
2
, (CH
2
)
t
—R
2
or the side-chain of a naturally occuring amino acid;,
Z
2
is CO—R
2
, CS—R
2
or (CH
2
)
t
—R
3
or the side-chain of a naturally occuring amino acid;
Z
3
is CO—R
2
, CS—R
2
or (CH
2
)
t
—R
4
or the side-chain of a naturally occuring amino acid;
Z
4
is H, alkyl, alkoxy, or cycloalkyl;
R
1
, R
2
, R
3
, and R
4
are independently from each other H, OH, SH, NH
2
, CN, NO
2
, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl, alkylthio, haloalkyloxy, hydroxyalkyl, hydroxyalkylamino, alkylamino, alkylaryl, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxyalkyl, alkoxy, aryloxy, heteroaryl, aryl, or halogen.
该发明涉及一般式（I）化合物及其盐和生理功能衍生物，
其中
Y为—NR
a
R
b
，—NR
c
C═ONR
a
R
b，
—NR
c
C═SNR
a
R
b
，—NR
c
C═NR
d
N
a
R
b
，杂环，—C═ONR
a
R
b
，杂环或芳基；n为0至8；m为0或1；r为0至3；t为0至3；X为O或N；
Z为CH
2
，C═O，C═S或单键；
Z
1
为CO—R
2
，CS—R
2
，（CH
2
）
t
—R
2
或天然氨基酸的侧链；，
Z
2
为CO—R
2
，CS—R
2
或（CH
2
）
t
—R
3
或天然氨基酸的侧链；
Z
3
为CO—R
2
，CS—R
2
或（CH
2
）
t
—R
4
或天然氨基酸的侧链；
Z
4
为H，烷基，烷氧基或环烷基；
R
1
，R
2
，R
3
和R
4
彼此独立地为H，OH，SH，NH
2
，CN，NO
2
，烷基，环烷基，杂环烷基，卤代烷基，烷硫基，卤代烷氧基，羟基烷基，羟基氨基，烷基氨基，烷基芳基，烷基亚砜基，烷基砜基，烷硫基烷基，烷基亚砜基烷基，烷基砜基烷基，烷氧基烷基，烷氧基，芳氧基，杂芳基，芳基或卤素。
