(3-氨基-2-甲基丙基)二甲基胺 | 6105-72-2

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (3-氨基-2-甲基丙基)二甲基胺
• 英文名称: N¹,N¹,2-trimethylpropane-1,3-diamine
• 英文别名: 3-(dimethylamino)-2-methylpropylamine；3-dimethylamino-2-methylpropylamine；N,N,2-trimethylpropane-1,3-diamine；2-Methyl-3-dimethylamino-1-propylamin；2-Methyl-3-dimethylaminopropylamin；N,N,2-Trimethyl-1,3-propandiamin；(3-Amino-2-methylpropyl)dimethylamine；N',N',2-trimethylpropane-1,3-diamine
• CAS: 6105-72-2
• 化学式: C₆H₁₆N₂
• mdl: MFCD09864543
• 分子量: 116.206
• InChiKey: DAMJSIMZZSEQRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2921290000
• WGK Germany：
  3

SDS

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SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : (3-Amino-2-methylpropyl)dimethylamine
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 6105-72-2
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Dermal (Category 4), H312
Skin corrosion (Category 1B), H314
Skin sensitisation (Category 1), H317
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
C Corrosive R21/22, R34, R43
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Danger
Hazard statement(s)
H302 + H312 Harmful if swallowed or in contact with skin
H314 Causes severe skin burns and eye damage.
H317 May cause an allergic skin reaction.
Precautionary statement(s)
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
Supplemental Hazard none
Statements
Other hazards - none

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SECTION 3: Composition/information on ingredients
Substances
Synonyms : N,N,2-Trimethylpropane-1,3-diamine
Formula : C6H16N2
Molecular Weight : 116,20 g/mol
CAS-No. : 6105-72-2
EC-No. : 228-061-0
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
N,N,2-Trimethylpropane-1,3-diamine
CAS-No. 6105-72-2 Acute Tox. 4; Skin Corr. 1B; <= 100 %
EC-No. 228-061-0 Skin Sens. 1; H302 + H312,
H314, H317
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
N,N,2-Trimethylpropane-1,3-diamine
CAS-No. 6105-72-2 C, R21/22 - R34 - R43 <= 100 %
EC-No. 228-061-0
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a
physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

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SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Evacuate personnel to safe areas.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
tested and approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

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SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
In the event of fire: see section 5

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SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

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SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

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SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

---

SECTION 14: Transport information
UN number
ADR/RID: 2735 IMDG: 2735 IATA: 2735
UN proper shipping name
ADR/RID: AMINES, LIQUID, CORROSIVE, N.O.S. (N,N,2-Trimethylpropane-1,3-diamine)
IMDG: AMINES, LIQUID, CORROSIVE, N.O.S. (N,N,2-Trimethylpropane-1,3-diamine)
IATA: Amines, liquid, corrosive, n.o.s. (N,N,2-Trimethylpropane-1,3-diamine)
Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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SECTION 15 - REGULATORY INFORMATION
N/A

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (3-氨基-2-甲基丙基)二甲基胺 在 氢溴酸 作用下， 反应 28.0h， 生成 11-(3-dimethylamino-2-methyl-propylamino)-8-methyl-7H-benzo[e]pyrido[4,3-b]indol-3-ol
  参考文献：
  名称：

  1-[[[（二烷基氨基）烷基]氨基] -4-甲基-5H-吡啶基[4,3-b]苯并[e]-和-苯并[g]）吲哚的合成及抗肿瘤活性。一类新的抗肿瘤药。

  摘要：

  4-肼基-5-甲基-1H-吡啶-2-一和各种β-和α-四氢萘酮生成的hydr的热费歇尔吲哚化反应生成4-甲基-6,7-二氢-2H，5H-吡啶[4分别是，3-3-b]苯并[e]吲哚-1-酮和4-甲基-11-二氢-2H，5H-吡啶基[4，3-b]苯并[g]吲哚-1-酮。芳香化后，将这些化合物用三氯氧化磷转化，得到1-氯-4-甲基-5H-吡啶并[4,3-b]苯并[e]-和-苯并[g]吲哚，它们被[（二烷基氨基）]取代烷基]胺。所得的1-[[[（二烷基氨基）烷基]氨基] -4-甲基-5H-吡啶-[4,3-b]苯并[e]-和-苯并[g]吲哚以及通过脱甲基化获得的羟基衍生物甲氧基化的化合物与氢溴酸，使用标准NCI方案在各种实验性肿瘤模型上测试了体外（白血病和实体瘤细胞）和体内的抗肿瘤活性。1-[[[3-（二烷基氨基）丙基]-氨基] -4-甲基-9-羟基-5H-吡啶基[4,3-b]苯并[e]吲哚似乎是有前途的新型抗肿瘤药。

  DOI：

  10.1021/jm00167a037
• 作为产物：
  描述：

  1,1,4-Trimethyl-2-pyrazolinium 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 (3-氨基-2-甲基丙基)二甲基胺
  参考文献：
  名称：

  Synthesis of some cis- and trans-2-dimethylaminomethyl cyclic amines and related diamines

  摘要：

  DOI：

  10.1021/jo00891a005

文献信息

• Continuous Method For Producing Amides Of Aromatic Carboxylic Acids
  申请人：Krull Matthias

  公开号：US20120095238A1

  公开（公告）日：2012-04-19

  The invention relates to a continuous method for producing amides of aromatic carboxylic acids by reacting at least one carbonic acid ester of formula (I) R 3 —OOOR 4 , wherein R 3 represents an optionally substituted aromatic hydrocarbon group with 5 to 100 carbon atoms and R 4 represents a hydrocarbon group with 1 to 30 carbon atoms, with at least one amine of formula (II) HNR 1 R 2 , wherein R 1 and R 2 independently represent hydrogen or a hydrocarbon group with 1 to 100 C atoms, in a reaction tube the longitudinal axis of which extends in the direction of propagation of the microwaves of a monomode microwave applicator, under microwave irradiation to form carboxamide.

  该发明涉及一种连续方法，通过在至少一种具有式(I) R3—OOOR4的碳酸酯中，其中R3代表一个具有5至100个碳原子的可选择取代的芳香烃基，R4代表一个具有1至30个碳原子的碳氢基团，与至少一种具有式(II) HNR1R2的胺反应，其中R1和R2独立地代表氢或具有1至100个C原子的碳氢基团，在一个反应管中，在单模微波应用器的微波传播方向上的纵轴下，通过微波辐射形成羧酰胺。
• Continuous Method for Producing Amides of Ethylenically Unsaturated Carboxylic Acids
  申请人：Krull Matthias

  公开号：US20110089020A1

  公开（公告）日：2011-04-21

  The invention relates to a continuous method for producing amides, according to which at least one carboxylic acid of formula (I) R 3 -COON (I), wherein R 3 is an optionally substituted alkenyl group comprising between 2 and 4 carbon atoms, is reacted with at least one amine of formula (II) HNR 1 R 2 (II), wherein R 1 and R 2 are independently hydrogen or a hydrocarbon radical comprising between 1 and 100 C atoms, to form an ammonium salt and/or a Michael adduct, and said ammonium salt is then reacted to form a carboxylic acid amide. under microwave irradiation in a reaction pipe, the longitudinal axis of the pipe being oriented in the direction of propagation of the microwaves of a monomode microwave applicator.

  该发明涉及一种连续生产酰胺的方法，根据该方法，至少一个具有化学式（I）R3-COON（I）的羧酸发生反应，其中R3是一个由2至4个碳原子组成的可选择取代的烯基基团，与至少一个具有化学式（II）HNR1R2（II）的胺发生反应，其中R1和R2独立地是氢或包含1至100个碳原子的烃基团，形成铵盐和/或迈克尔加合物，然后将所述铵盐反应形成羧酸酰胺，在微波辐射下在反应管内进行，管的纵轴朝向单模微波应用器的微波传播方向。
• Method For Producing Alkaline (Meth)Acrylamides
  申请人：Krull Matthias

  公开号：US20100032284A1

  公开（公告）日：2010-02-11

  The invention relates to a method for producing alkaline amides or imides of ethylenically unsaturated C 3 to C 6 carboxylic acids by reacting amines that contain at least one primary and/or secondary amino group and at least one tertiary amino group with ethylenically unsaturated C 3 to C 6 carboxlic acids to form an ammonium salt and said ammonium salt is subsequently converted into the alkaline amide or imide by means of microwave radiation, with the proviso that the primary and/or secondary amino group is devoid of alkoxy groups.

  该发明涉及一种通过将含有至少一个一次和/或二次氨基团和至少一个三次氨基团的胺与乙烯基不饱和的C3到C6羧酸反应，形成铵盐，然后通过微波辐射将所述铵盐转化为碱性酰胺或亚胺的方法。前提是一次和/或二次氨基团不含有烷氧基。
• BICYCLIC CX3CR1 RECEPTOR AGONISTS
  申请人：Board of Regents, The University of Texas System

  公开号：US20210024510A1

  公开（公告）日：2021-01-28

  Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.

  本文披露了一种新颖的环烷基[b]杂环芳烃化合物，具有CX3CR1/趋化因子受体（CX3CR1）激动性特性，包括这些化合物的药物组合物，制备这些化合物的化学过程以及它们在治疗或预防与动物中的CX3CR1受体活性相关的疾病，尤其是人类中的用途。
• [EN] COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DU CANCER
  申请人：UNIV CALIFORNIA

  公开号：WO2018005678A1

  公开（公告）日：2018-01-04

  The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one or more pyrazolyl-containing compounds, or a derivative thereof.

  本公开提供了化合物、药物组合物以及治疗癌症和纤维化的方法。所述的药物组合物可能包括一个或多个吡唑基含有化合物，或其衍生物。