α-acetyl-α-octyl-γ-butyrolactone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: α-acetyl-α-octyl-γ-butyrolactone
• 英文别名: 3-Acetyl-3-octyloxolan-2-one
• 化学式: C₁₄H₂₄O₃
• 分子量: 240.343
• InChiKey: ZXWMJQOYZANBIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  α-乙酰基-γ-丁内酯 、 辛烯 在 cobalt(II) acetate 、 manganese(II) acetate 氮气 、 氧气 、 溶剂黄146 作用下， 90.0 ℃ 、101.0 kPa 条件下， 反应 14.0h， 以71%的产率得到α-acetyl-α-octyl-γ-butyrolactone
  参考文献：
  名称：

  PROCESS FOR THE PREPARATION OF ORGANIC COMPOUNDS WITH MANGANESE CATALYSTS OR THE LIKE

  摘要：

  公开号：

  EP1178031B1

文献信息

• Catalytic Radical Addition of Carbonyl Compounds to Alkenes by Mn(II)/Co(II)/O₂ System
  作者：Kouji Hirase、Takahiro Iwahama、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1021/jo0162282

  日期：2002.2.1

  The radical addition of enolizable carbonyl compounds such as malonates and malononitrile to alkenes was successfully achieved through a catalytic process using the Mn(II)/Co(II)/O(2) system to afford the corresponding adducts in fair to good yields. Dimethyl malonate added to 1,5-cyclooctadiene to produce a fused bicycle compound.

  可催化的羰基化合物（如丙二酸酯和丙二腈）向烯烃的自由基加成反应是通过使用Mn（II）/ Co（II）/ O（2）系统的催化过程成功完成的，以公平到良好的收率提供了相应的加合物。将丙二酸二甲酯添加到1,5-环辛二烯中以生成稠合的自行车化合物。
• Process for the preparation of organic compounds with manganese cataylsts or the like
  申请人：——

  公开号：US20020165416A1

  公开（公告）日：2002-11-07

  A process of the present invention produces an organic compound by allowing a compound containing an electron attractive group of following Formula (1): 1 wherein Y is an electron attractive group; and R b and R c are each a hydrogen atom or an organic group, where Y, R b and R c may respectively be combined with each other to form a ring with an adjacent carbon atom, to react with a compound containing an unsaturated carbon-carbon bond of following Formula (2) or 2 wherein R d , R e , R f , R g , R i and R j are each a hydrogen atom or an organic group, where R d , R e , R f and R g may respectively be combined to form a ring with one or two adjacent carbon atoms, and R i and R j may be combined to form a ring with adjacent two carbon atoms, in the presence of oxygen and a catalytic compound of a Group 5, 6, 7, 8 or 9 element of the Periodic Table of Elements to yield a compound of following Formula (3) or (8): 3 wherein Z is a hydrogen atom or a hydroxyl group; and Y, R b , R c , R d , R e , R f , R g , R i and R j have the same meanings as defined above. This process can efficiently produce a compound having an alkyl group or alkenyl group bonded at the alpha position of an electron attractive group, or a derivative thereof, by catalytic radical addition reaction.

  本发明的一种过程通过允许含有下式（1）中的电子亲合基团的化合物与含有下式（2）的不饱和碳-碳键的化合物在氧气和周期表元素的5、6、7、8或9族的催化化合物存在下反应，产生下式（3）或（8）的化合物： 其中Y是一个电子亲合基团；Rb和Rc分别是氢原子或有机基团，其中Y、Rb和Rc可以分别结合在一起形成与相邻碳原子的环；Rd、Re、Rf、Rg、Ri和Rj分别是氢原子或有机基团，其中Rd、Re、Rf和Rg可以分别结合在一起形成与一个或两个相邻碳原子的环，而Ri和Rj可以结合在一起形成与相邻两个碳原子的环。这个过程可以通过催化自由基加成反应高效地产生在电子亲合基团的α位结合有烷基或烯基基团的化合物，或其衍生物。
• US6548713B2
  申请人：——

  公开号：US6548713B2

  公开（公告）日：2003-04-15
• PROCESS FOR THE PREPARATION OF ORGANIC COMPOUNDS WITH MANGANESE CATALYSTS OR THE LIKE
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP1178031B1

  公开（公告）日：2012-02-01