2-[2-[2-(2-苯氧乙氧基]乙氧基]乙氧基]乙醇 | 36366-93-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-[2-[2-(2-苯氧乙氧基]乙氧基]乙氧基]乙醇
• 中文别名: 四乙二醇单苯醚
• 英文名称: 2-<2-<2-(2-phenoxyethoxy)ethoxy>ethoxy>ethanol
• 英文别名: 1-hydroxy-11-phenoxy-3,6,9-trioxaundecane；12-phenyl-3,6,9,12-tetraoxadodecanol；11-(Phenoxy)-3,6,9-trioxa-1-undecanol；tetraethylene glycol monophenyl ether；2-{2-[2-(2-phenoxyethoxy)ethoxy]ethoxy}ethanol；11-phenoxy-3,6,9-trioxa-undecan-1-ol；tetraethylene glycol phenyl ether；2-(2-(2-(2-Phenoxyethoxy)ethoxy)ethoxy)ethanol；2-[2-[2-(2-phenoxyethoxy)ethoxy]ethoxy]ethanol
• CAS: 36366-93-5
• 化学式: C₁₄H₂₂O₅
• 分子量: 270.326
• InChiKey: RGRVGOMPHMWMJX-UHFFFAOYSA-N

物化性质

• 沸点：
  373.44°C (rough estimate)
• 密度：
  1.1599 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2909499000

反应信息

• 作为反应物：
  描述：

  2-[2-[2-(2-苯氧乙氧基]乙氧基]乙氧基]乙醇 在 palladium on activated charcoal 吡啶 、 tetrafluoroboric acid 、 氢气 、 sodium nitrite 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 25.0 ℃ 、344.73 kPa 条件下， 反应 21.17h， 生成 2-<2-<2-<2-<(diazonium tetrafluoroborate)benzoyloxy>ethoxy>ethoxy>ethoxy>ethoxybenzene
  参考文献：
  名称：

  Phase-transfer-catalyzed Gomberg-Bachmann synthesis of unsymmetrical biarenes: a survey of catalysts and substrates

  摘要：

  DOI：

  10.1021/jo00183a021
• 作为产物：
  描述：

  2-(2-苯氧基乙氧基)乙醇 在 氢氧化钾 、 三溴化磷 作用下， 以 吡啶 、 水 为溶剂， 反应 4.0h， 生成 2-[2-[2-(2-苯氧乙氧基]乙氧基]乙氧基]乙醇
  参考文献：
  名称：

  Selective bromination of the aromatic ring in ω-phenylpolyoxaalkanes and alkanols in micelles

  摘要：

  DOI：

  10.1016/s0040-4020(01)85934-2

文献信息

• BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas Operations, Inc.

  公开号：US20190300521A1

  公开（公告）日：2019-10-03

  The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为SMARCA2或BRM（靶蛋白）的调节剂具有实用性。具体而言，本公开涉及包含一端结合Von Hippel-Lindau E3泛素连接酶的配体，另一端结合靶蛋白的双功能化合物，使得靶蛋白与泛素连接酶靠近以实现靶蛋白的降解（和抑制）。本公开展示了与靶蛋白降解/抑制相关的广泛药理活性。本公开的化合物和组合物用于治疗或预防由靶蛋白聚集或积累导致的疾病或紊乱。
• Softener composition
  申请人：Ushio Noriaki

  公开号：US20050090423A1

  公开（公告）日：2005-04-28

  A softener composition that can impart a high softening effect to clothes irrespective of the state of rinsing water, which contains (a) a compound of formula (1) below, (b) a compound of formula (3) below, and (c) a specific anionic surfactant, wherein the mole ratios between the components (a), (b) and (c) satisfy the following relationship: [(a)+(b)]/(c)=9/1 to 4/6; and wherein R 1 represents a C 13-36 alkyl group or the like, R 10 and R 12 respectively represent a C 8-36 alkyl group or the like, R 2 , R 11 and R 13 respectively represent a C 1-6 alkylene group, R 3 , R 4 , and R 14 respectively represent a C 1-3 alkyl group or the like, A, D and E respectively represent —COO—, —CONH— or the like, and “a”, “c” and “d” respectively denote 0 or 1.

  一种软化剂组合物，可以在漂洗水的状态不同的情况下赋予衣物高度的柔软效果，该组合物包含以下的化合物：(a) 下式的化合物，(b) 下式的化合物，以及(c) 特定的阴离子表面活性剂，其中组分(a)、(b)和(c)之间的摩尔比满足以下关系：[(a)+(b)]/(c)=9/1至4/6；其中R1代表C13-36烷基基团或类似物，R10和R12分别代表C8-36烷基基团或类似物，R2、R11和R13分别代表C1-6烷基烯基基团，R3、R4和R14分别代表C1-3烷基基团或类似物，A、D和E分别代表—COO—、—CONH—或类似物，“a”、“c”和“d”分别表示0或1。
• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE
  申请人：Arvinas, Inc.

  公开号：US20180177750A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of enhancer of zeste homolog 2 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为增强子锁定同源2的调节剂而发挥作用。具体而言，本公开涉及包含一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源2配体的双功能化合物，该配体与相应的E3泛素连接酶结合，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白聚集或积累导致的疾病或紊乱。
• CURABLE COMPOSITION FOR IMPRINTS AND PRODUCING METHOD OF POLYMERIZABLE MONOMER FOR IMPRINTS
  申请人：Kodama Kunihiko

  公开号：US20120076950A1

  公开（公告）日：2012-03-29

  Provided is a curable composition for imprints excellent in pattern transferability. Disclosed is a curable composition for imprints comprising a polymerizable monomer (A) and a polymerization initiator (B), which is substantially free from a polymer which contains at least one species of the polymerizable monomer (A) as a repeating unit.

  提供了一种适用于图案易传递的可治愈组合物。公开了一种适用于图案印记的可治愈组合物，包括可聚合单体（A）和聚合引发剂（B），其基本上不含至少一种将可聚合单体（A）作为重复单元的聚合物。
• CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF
  申请人：SEGETIS, INC.

  公开号：US20140147395A1

  公开（公告）日：2014-05-29

  This disclosure is directed to compound of formula (1): wherein R 1 is a C 7-18 alkyl, R 2 is hydrogen or a C 1-3 alkyl, each R 3 , R 4 , R 5 , R 6 , and R 7 is independently hydrogen or a C 1-6 alkyl, a is 2-3, and b is 0-1, its method of preparation and uses thereof in water-borne coating compositions, cleaning compositions, fragrance, and personal care compositions.

  这项披露涉及到化合物的结构式(1)：其中R1是C7-18烷基，R2是氢或C1-3烷基，每个R3、R4、R5、R6和R7独立地是氢或C1-6烷基，a为2-3，b为0-1，以及其在水性涂料组合物、清洁组合物、香料和个人护理组合物中的制备方法和用途。