L-xylo-3,4,5,6-Tetrahydroxy-1-phosphonooxy-hexan-2-on | 49594-02-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: L-xylo-3,4,5,6-Tetrahydroxy-1-phosphonooxy-hexan-2-on
• 英文别名: O¹-Phosphono-L-sorbose；L-Sorbose-1-phosphat；L-sorbose 1-phosphate；[(3S,4R,5S)-3,4,5,6-tetrahydroxy-2-oxohexyl] dihydrogen phosphate
• CAS: 49594-02-7
• 化学式: C₆H₁₃O₉P
• 分子量: 260.138
• InChiKey: ZKLLSNQJRLJIGT-OTWZMJIISA-N

物化性质

• 沸点：
  692.5±65.0 °C(Predicted)
• 密度：
  1.840±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  165
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  双丙酮-L-山梨糖 在 吡啶 、 甲醇 、 铂 作用下， 生成 L-xylo-3,4,5,6-Tetrahydroxy-1-phosphonooxy-hexan-2-on
  参考文献：
  名称：

  Mann; Lardy, Journal of Biological Chemistry, 1950, vol. 187, p. 339,343

  摘要：

  DOI：

文献信息

• Fructose-1,6-diphosphate aldolase from spinach leaves, a challenger for enzymatic synthesis of ketoses
  作者：Marie-Lise Valentin、Jean Bolte

  DOI：10.1016/s0040-4039(00)61463-6

  日期：1993.12

  Fructose-1,6-diphosphate aldolase is easily extracted from spinach leaves in a form sufficiently pure to be used in synthesis. Its specificity, different from that of the commercial rabbit muscle aldolase make it a new interesting tool for the synthesis of ketoses-1-phosphates.
• A PHARMACEUTICAL COMPOSITION COMPRISING A PHOSPHOSUGAR
  申请人：PERSTORP AB

  公开号：EP0506772A1

  公开（公告）日：1992-10-07
• [EN] A PHARMACEUTICAL COMPOSITION COMPRISING A PHOSPHOSUGAR
  申请人：PERSTORP AB

  公开号：WO1991009604A1

  公开（公告）日：1991-07-11

  (EN) The present invention relates to a pharmaceutical composition and to the use of a compound of formula (I): (OH)6-p-(C4+nH5+mO)-(OPO3H2)p, where n=1, 2 or 3, m=1, 2 or 3, p=1, 2 or 3 for the preparing of a medicament for preventing, alleviating or combatting different conditions in mammals including man.(FR) L'invention concerne une composition pharmaceutique et l'utilisation d'un composé de formule (I): (OH)6-p-(C4+nH5+mO)-(OPO3H2)p, où n=1, 2 ou 3, m=1, 2, ou 3, p=1, 2 ou 3, pour la préparation d'un médicament permettant de prévenir, de soulager ou de combattre différentes affections chez les mammifères, y compris l'homme.
• [EN] ACTIVATION OF RAS BY A FRUCTOSE-1,6-BISPHOSPHATE / GUANINE NUCLEOTIDE EXCHANGE PROTEIN COMPLEX<br/>[FR] ACTIVATION DE RAS PAR UN COMPLEXE DE PROTÉINE D'ÉCHANGE NUCLÉOTIDIQUE FRUCTOSE-1,6-BISPHOSPHATE / GUANINE
  申请人：VIB VZW

  公开号：WO2015011222A1

  公开（公告）日：2015-01-29

  The present invention relates to an isolated fructose-1,6-bisphosphate / SOS complex. The invention relates further to the use of the complex to screen for compounds that modulate the activation of Ras, and the use of yeast strains for said screening. The invention relates also to compounds, disrupting the fructose-1,6-bisphosphate / SOS complex and the use of such compounds in the treatment of cancer.
• Mann; Lardy, Journal of Biological Chemistry, 1950, vol. 187, p. 339,343
  作者：Mann、Lardy

  DOI：——

  日期：——